In deze aflevering duiken Tom en Alexander diep in de hype rondom Ozempic en andere afslankmedicatie. Wat doet het middel precies in je lichaam? Voor wie is het bedoeld, en wat gebeurt er als je ermee stopt? Met wetenschap als leidraad scheiden ze feiten van fabels.

In deze aflevering:

💉 Wat is Ozempic precies en hoe werkt het in je lichaam?
⏳ Verkort Ozempic je levensduur, of juist niet?
😬 Bestaat “Ozempic face” echt, of is dat gewoon normaal bij afvallen?
🔁 Kom je na Ozempic altijd weer aan?
🍋 Helpt citroenwater, zout en wandelen écht om snel af te vallen?

Tom stelt de vragen, Alexander ontrafelt de claims. Zodat jij aan het eind weet: wat is een bewezen hulpmiddel, wat is overschat, en wanneer een simpele leefstijlverandering minstens zo effectief is als een spuitje.

Lang zal je leven, maar wel met verstand.

🎧 Geproduceerd door Tonny Media
👉 Volg ons op Instagram, TikTok en YouTube
🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier:

• Aamir AB, Latif R, Alqoofi JF, Almarzoq FA, Fallatah JO, Hassan GA, Saab FAAAA. Comparative Efficacy of Tirzepatide vs. Semaglutide in Reducing Body Weight in Humans: A Systematic Review and Meta-Analysis of Clinical Trials and Real-World Data. J Clin Med Res. 2025 May;17(5):285-296. doi: 10.14740/jocmr6231. Epub 2025 May 13. PMID: 40503067; PMCID: PMC12151102.
• McGowan B, Ciudin A, Baker JL, Busetto L, Dicker D, Frühbeck G, Goossens GH, Monami M, Sbraccia P, Martinez-Tellez B, Woodward E, Yumuk V. A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults. Nat Med. 2025 Oct;31(10):3317-3329. doi: 10.1038/s41591-025-03978-z. Epub 2025 Oct 2. PMID: 41039116; PMCID: PMC12532627.
• Bacha Z, Javed J, Sheraz M, Sikandar M, Zakir M, Ali MA, Khan M, Iqbal A, Rehman A, Alam U, Ahmed R. Efficacy and Safety of Semaglutide on Cardiovascular Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cardiol Rev. 2025 Sep 19. doi: 10.1097/CRD.0000000000001057. Epub ahead of print. PMID: 40968407.
• Sillassen CDB, Petersen JJ, Faltermeier P, Yucel D, Siddiqui F, Andersen RK, Graever L, Bjerg JL, Kamp CB, Grand J, Dominguez H, Frølich A, Gæde P, Gluud C, Mathiesen O, Jakobsen JC. The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis. BMC Med. 2025 Nov 24;23(1):654. doi: 10.1186/s12916-025-04486-0. PMID: 41286875; PMCID: PMC12642075.
• Yao Y, Liu N, Chen S, Sun M, Guo Y. Semaglutide reduces cardiovascular events in type 2 diabetes: a systematic review and meta-analysis highlighting enhanced benefits in chronic kidney disease. Eur J Med Res. 2025 Nov 4;30(1):1059. doi: 10.1186/s40001-025-03241-8. PMID: 41188987; PMCID: PMC12584374.
• Wu R, Xing B, Zhou Z, Yu L, Wang H. Effect of semaglutide on arrhythmic, major cardiovascular, and renal outcomes in patients with overweight or obesity: a systematic review and meta-analysis. Eur J Med Res. 2025 Sep 2;30(1):835. doi: 10.1186/s40001-025-03124-y. PMID: 40890879; PMCID: PMC12403603.
• Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornøe CW, Ryan DH; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563. Epub 2023 Nov 11. PMID: 37952131.
• Galli M, Benenati S, Laudani C, Simeone B, Sarto G, Ortega-Paz L, Rocco E, Bernardi M, Spadafora L, D'Amario D, Greco E, Frati G, Federici M, Mehran R, Crea F, Angiolillo DJ, Sciarretta S. Cardiovascular Effects and Tolerability of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis of 99,599 Patients. J Am Coll Cardiol. 2025 Nov 18;86(20):1805-1819. doi: 10.1016/j.jacc.2025.08.027. Epub 2025 Aug 27. PMID: 40892610.
• Shuja SH, Shuja MH, Shaukat A, Hannat R, Ahmed I, Adam S, Abdelkhalek A, Changez MIK, Ullah I, Ahmed R, Cortese B. GLP-1 Receptor Agonists and Cardiovascular Outcomes in Adults With Diabetes and Peripheral Artery Disease: An Updated Systematic Review and Meta-Analysis. Am J Cardiol. 2026 Jan 1;258:268-275. doi: 10.1016/j.amjcard.2025.09.039. Epub 2025 Sep 27. PMID: 41022246.
• Anyiam O, Ardavani A, Rashid RSA, Panesar A, Idris I. How do glucagon-like Peptide-1 receptor agonists affect measures of muscle mass in individuals with, and without, type 2 diabetes: A systematic review and meta-analysis. Obes Rev. 2025 Jul;26(7):e13916. doi: 10.1111/obr.13916. Epub 2025 Apr 3. PMID: 40181228; PMCID: PMC12137041.
• Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB. Muscle matters: the effects of medically induced weight loss on skeletal muscle. Lancet Diabetes Endocrinol. 2024 Nov;12(11):785-787. doi: 10.1016/S2213-8587(24)00272-9. Epub 2024 Sep 9. PMID: 39265590.
• Karakasis P, Patoulias D, Fragakis N, Mantzoros CS. Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis. Metabolism. 2025 Mar;164:156113. doi: 10.1016/j.metabol.2024.156113. Epub 2024 Dec 22. PMID: 39719170.
• Kolli RT, Aoutla S, Jyothi N, Mohamed Kalifa MRH, Raju A, Cheenikkal Muralidharan K. Rebound or Retention: A Meta-Analysis of Weight Regain After the Discontinuation of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists and Other Anti-obesity Drugs. Cureus. 2025 Oct 19;17(10):e94926. doi: 10.7759/cureus.94926. PMID: 41116804; PMCID: PMC12535773.
• Berg S, Stickle H, Rose SJ, Nemec EC. Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis. Obes Rev. 2025 Aug;26(8):e13929. doi: 10.1111/obr.13929. Epub 2025 Apr 4. PMID: 40186344.
• Quarenghi M, Capelli S, Galligani G, Giana A, Preatoni G, Turri Quarenghi R. Weight Regain After Liraglutide, Semaglutide or Tirzepatide Interruption: A Narrative Review of Randomized Studies. J Clin Med. 2025 May 28;14(11):3791. doi: 10.3390/jcm14113791. PMID: 40507553; PMCID: PMC12155999.
• Kılıç S. Facial aging after GLP-1 receptor agonist-induced weight loss: the emerging Ozempic face phenomenon. J Diabetes Metab Disord. 2025 Nov 6;24(2):261. doi: 10.1007/s40200-025-01778-3. PMID: 41210112; PMCID: PMC12592601.
• Chu J, Zhang H, Wu Y, Huang Y, Zhu T, Zhou Z, Wang H. Efficacy of lifestyle modification combined with GLP-1 receptor agonists on body weight and cardiometabolic biomarkers in individuals with overweight or obesity: a systematic review and meta-analysis. EClinicalMedicine. 2025 Aug 30;88:103464. doi: 10.1016/j.eclinm.2025.103464. PMID: 40926900; PMCID: PMC12414836.
• Wong HJ, Sim B, Teo YH, Teo YN, Chan MY, Yeo LLL, Eng PC, Tan BYQ, Sattar N, Dalakoti M, Sia CH. Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference for Patients With Obesity or Overweight: A Systematic Review, Meta-analysis, and Meta-regression of 47 Randomized Controlled Trials. Diabetes Care. 2025 Feb 1;48(2):292-300. doi: 10.2337/dc24-1678. PMID: 39841962.
• Codella R, Senesi P, Luzi L. GLP-1 agonists and exercise: the future of lifestyle prioritization. Front Clin Diabetes Healthc. 2025 Nov 24;6:1720794. doi: 10.3389/fcdhc.2025.1720794. PMID: 41367404; PMCID: PMC12683586.
• De Amicis R, Foppiani A, Leone A, Sileo F, Menichetti F, Mambrini SP, Pellizzari M, Tucci M, Martini D, Del Bo C, Riso P, Bertoli S, Battezzati A. How sustainable are hypocaloric and balanced diets for weight loss? Nutr Metab (Lond). 2025 Jun 10;22(1):58. doi: 10.1186/s12986-025-00937-w. PMID: 40495206; PMCID: PMC12153144.
• Cigrovski Berkovic M, Ruzic L, Cigrovski V, Strollo F. Saving muscle while losing weight: A vital strategy for sustainable results while on glucagon-like peptide-1 related drugs. World J Diabetes. 2025 Sep 15;16(9):109123. doi: 10.4239/wjd.v16.i9.109123. PMID: 40980310; PMCID: PMC12444289.
• Ruseva A, Michalak W, Fabricatore A, Hartaigh BÓ, Zhao Z, Wang J, Umashanker D. Sustained weight reduction with once-weekly semaglutide: results from a real-world retrospective cohort study in the United States (SCOPE 24 months). Curr Med Res Opin. 2025 Dec 6:1-12. doi: 10.1080/03007995.2025.2591464. Epub ahead of print. PMID: 41351543.
• Reiss AB, Gulkarov S, Lau R, Klek SP, Srivastava A, Renna HA, De Leon J. Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss. Biomolecules. 2025 Mar 13;15(3):408. doi: 10.3390/biom15030408. PMID: 40149944; PMCID: PMC11940170.

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In deze aflevering:

🥫 Ultrabewerkt voedsel veroorzaakt dementie
🍓 Er zit veel pfas op fruit en groente en dit is schadelijk voor je gezondheid
🧴 Microplastics veroorzaken gezondheidsproblemen dus drink uit glas.
🚰  In Nederland moet je je kraanwater filteren om gezond te blijven. 

Tom stelt de vragen, Alexander fileert de feiten. Zodat jij voortaan weet: wat is een terechte zorg voor je gezondheid, wat is overdreven angst en wanneer je TikTok beter even kunt wegklikken.🎧 Geproduceerd door Tonny Media
👉 Volg ons op Instagram, TikTok en YouTube
🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier:

Onderzoek: 

• Pagliai G, Dinu M, Madarena MP, Bonaccio M, Iacoviello L, Sofi F. Consumption of ultra-processed foods and health status: a systematic review and meta-analysis. Br J Nutr. 2021 Feb 14;125(3):308-318. doi: 10.1017/S0007114520002688. Epub 2020 Aug 14. PMID: 32792031; PMCID: PMC7844609.
• Winiarska E, Jutel M, Zemelka-Wiacek M. The potential impact of nano- and microplastics on human health: Understanding human health risks. Environ Res. 2024 Jun 15;251(Pt 2):118535. doi: 10.1016/j.envres.2024.118535. Epub 2024 Mar 7. PMID: 38460665.
• Lane MM, Gamage E, Du S, Ashtree DN, McGuinness AJ, Gauci S, Baker P, Lawrence M, Rebholz CM, Srour B, Touvier M, Jacka FN, O'Neil A, Segasby T, Marx W. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ. 2024 Feb 28;384:e077310. doi: 10.1136/bmj-2023-077310. PMID: 38418082; PMCID: PMC10899807.
• Yeoh CSL, Alrazihi LA, Wong ST, Wong SF. Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan. Environ Toxicol Chem. 2025 Oct 1;44(10):2754-2786. doi: 10.1093/etojnl/vgaf172. PMID: 40627414.
• Mendoza K, Smith-Warner SA, Rossato SL, Khandpur N, Manson JE, Qi L, Rimm EB, Mukamal KJ, Willett WC, Wang M, Hu FB, Mattei J, Sun Q. Ultra-processed foods and cardiovascular disease: analysis of three large US prospective cohorts and a systematic review and meta-analysis of prospective cohort studies. Lancet Reg Health Am. 2024 Sep 2;37:100859. doi: 10.1016/j.lana.2024.100859. PMID: 39286398; PMCID: PMC11403639.
• Vitale M, Costabile G, Testa R, D'Abbronzo G, Nettore IC, Macchia PE, Giacco R. Ultra-Processed Foods and Human Health: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 2024 Jan;15(1):100121. doi: 10.1016/j.advnut.2023.09.009. Epub 2023 Dec 18. PMID: 38245358; PMCID: PMC10831891.
• Liang S, Zhou Y, Zhang Q, Yu S, Wu S. Ultra-processed foods and risk of all-cause mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies. Syst Rev. 2025 Mar 3;14(1):53. doi: 10.1186/s13643-025-02800-8. PMID: 40033461; PMCID: PMC11874696.
• Henney AE, Gillespie CS, Alam U, Hydes TJ, Mackay CE, Cuthbertson DJ. High intake of ultra-processed food is associated with dementia in adults: a systematic review and meta-analysis of observational studies. J Neurol. 2024 Jan;271(1):198-210. doi: 10.1007/s00415-023-12033-1. Epub 2023 Oct 13. PMID: 37831127; PMCID: PMC10770002.
• Pourmotabbed A, Talebi S, Mehrabani S, Babaei A, Khosroshahi RA, Bagheri R, Wong A, Ghoreishy SM, Amirian P, Zarpoosh M, Hojjati Kermani MA, Moradi S. The association of ultra-processed food intake with neurodegenerative disorders: a systematic review and dose-response meta-analysis of large-scale cohorts. Nutr Neurosci. 2025 Jan;28(1):73-86. doi: 10.1080/1028415X.2024.2351320. Epub 2024 May 16. PMID: 38753992.
• Gomes Gonçalves N, Vidal Ferreira N, Khandpur N, et al. Association Between Consumption of Ultraprocessed Foods and Cognitive Decline. JAMA Neurol. 2023;80(2):142–150. doi:10.1001/jamaneurol.2022.4397
• Torres FG, De-la-Torre GE. Per- and polyfluoroalkyl substances (PFASs) in consumable species and food products. J Food Sci Technol. 2023 Sep;60(9):2319-2336. doi: 10.1007/s13197-022-05545-7. Epub 2022 Jul 28. PMID: 37424586; PMCID: PMC10326201.
• Iannone A, Carriera F, Passarella S, Fratianni A, Avino P. There's Something in What We Eat: An Overview on the Extraction Techniques and Chromatographic Analysis for PFAS Identification in Agri-Food Products. Foods. 2024 Apr 1;13(7):1085. doi: 10.3390/foods13071085. PMID: 38611389; PMCID: PMC11011820.
• Blaine AC, Rich CD, Sedlacko EM, Hyland KC, Stushnoff C, Dickenson ER, Higgins CP. Perfluoroalkyl acid uptake in lettuce (Lactuca sativa) and strawberry (Fragaria ananassa) irrigated with reclaimed water. Environ Sci Technol. 2014 Dec 16;48(24):14361-8. doi: 10.1021/es504150h. Epub 2014 Nov 25. PMID: 25386873.
• Kumar N, Lamba M, Pachar AK, Yadav S, Acharya A. Microplastics - A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms. Cell Biochem Biophys. 2024 Dec;82(4):3109-3121. doi: 10.1007/s12013-024-01436-0. Epub 2024 Jul 20. PMID: 39031249.
• Nivedita J, Megha P, Daisy PS, Sivachandran R, Ramprasath A, Rajkumar M, Anitha TS. Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis. J Environ Pathol Toxicol Oncol. 2025;44(4):31-46. doi: 10.1615/JEnvironPatholToxicolOncol.2025054888. PMID: 41213061.
• Liu X, Wang L, Liu X, Yu P, Diao Y, Chen T, Sheng Y, Zhang D, Peng D, Guo Y, Li S, Xu R. Microplastics, plastics, and their products exposures and cancer: a pooled analysis. Int J Surg. 2025 Aug 1;111(8):5593-5605. doi: 10.1097/JS9.0000000000002631. Epub 2025 Jun 20. PMID: 40540244.
• Mishra SK, Sanyal T, Kundu P, Kumar R, Ghosh D, Chakrabarti G, Sikdar N, Bhattacharya S, Paul S, Das A. Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers. Mol Cancer. 2025 Oct 8;24(1):248. doi: 10.1186/s12943-025-02409-4. PMID: 41063167; PMCID: PMC12505851.
• Park S, Onufrak SJ, Cradock AL, Patel A, Hecht C, Blanck HM. Perceptions of Water Safety and Tap Water Taste and Their Associations With Beverage Intake Among U.S. Adults. Am J Health Promot. 2023 Jun;37(5):625-637. doi: 10.1177/08901171221150093. Epub 2023 Jan 6. PMID: 36609168; PMCID: PMC10239313.
• Geerts R, Vandermoere F, Van Winckel T, Halet D, Joos P, Van Den Steen K, Van Meenen E, Blust R, Borregán-Ochando E, Vlaeminck SE. Bottle or tap? Toward an integrated approach to water type consumption. Water Res. 2020 Apr 15;173:115578. doi: 10.1016/j.watres.2020.115578. Epub 2020 Jan 31. PMID: 32058152.
• https://wetten.overheid.nl/BWBR0030111/2018-07-01
• Gambino I, Bagordo F, Grassi T, Panico A, De Donno A. Occurrence of Microplastics in Tap and Bottled Water: Current Knowledge. Int J Environ Res Public Health. 2022 Apr 26;19(9):5283. doi: 10.3390/ijerph19095283. PMID: 35564678; PMCID: PMC9103198.
• Khu ST, Li F, Zhao W. Microplastics in drinking water distribution systems: Occurrence, environmental behavior, and human health concerns. Environ Pollut. 2025 Oct 1;382:126666. doi: 10.1016/j.envpol.2025.126666. Epub 2025 Jun 13. PMID: 40518066.
• Haleem N, Kumar P, Zhang C, Jamal Y, Hua G, Yao B, Yang X. Microplastics and associated chemicals in drinking water: A review of their occurrence and human health implications. Sci Total Environ. 2024 Feb 20;912:169594. doi: 10.1016/j.scitotenv.2023.169594. Epub 2023 Dec 27. PMID: 38154642.
• Hazzazi LW, Soto-Rojas AE, Martinez-Mier EA, Nassar HM, Eckert GJ, Lippert F. The effect of water filter pitchers on the mineral concentration of tap water. J Public Health Dent. 2025 Mar;85(1):21-28. doi: 10.1111/jphd.12649. Epub 2024 Nov 6. PMID: 39505386; PMCID: PMC11927951.
• Shayo GM, Elimbinzi E, Shao GN. Water-based technologies for improving water quality at the point of use: A review. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1940. doi: 10.1002/wnan.1940. PMID: 38456325.

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In deze aflevering:
💊 Neem probiotica en geen antibiotica
🧠 Je darmen zijn je tweede brein
⚖️ Je microbioom bepaalt hoe dik en hoe ziek je wordt
🚑 Poeptransplantaties redden levens

Tom stelt de vragen, Alexander fileert de feiten. Zodat jij voortaan weet: wat helpt je darmen écht, wat is dure onzin, en wanneer je beter niet blind een potje ‘probiotica power’ hoeft te kopen.

Onderzoeken uit deze aflevering:

• McDonnell L, Gilkes A, Ashworth M, Rowland V, Harries TH, Armstrong D, White P. Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis. Gut Microbes. 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2020.1870402. PMID: 33651651; PMCID: PMC7928022.
• de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022 May;71(5):1020-1032. doi: 10.1136/gutjnl-2021-326789. Epub 2022 Feb 1. PMID: 35105664; PMCID: PMC8995832.
• Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek. 2020 Dec;113(12):2019-2040. doi: 10.1007/s10482-020-01474-7. Epub 2020 Nov 2. PMID: 33136284.
• Lee J-Y, Bays DJ, Savage HP, Bäumler AJ. The human gut microbiome in health and disease: time for a new chapter? Infect Immun. 2024 Nov 12;92(11):e0030224. doi: 10.1128/iai.00302-24. Epub 2024 Sep 30. PMID: 39347570; PMCID: PMC11556149.
• Mayer EA, Nance K, Chen S. The Gut-Brain Axis. Annu Rev Med. 2022 Jan 27;73:439-453. doi: 10.1146/annurev-med-042320-014032. Epub 2021 Oct 20. PMID: 34669431.
• Petrut SM, Bragaru AM, Munteanu AE, Moldovan AD, Moldovan CA, Rusu E. Gut over Mind: Exploring the Powerful Gut-Brain Axis. Nutrients. 2025 Feb 28;17(5):842. doi: 10.3390/nu17050842. PMID: 40077713; PMCID: PMC11901622.
• Margolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology. 2021 Apr;160(5):1486-1501. doi: 10.1053/j.gastro.2020.10.066. Epub 2021 Jan 22. PMID: 33493503; PMCID: PMC8634751.
• Gupta K, Tappiti M, Nazir AM, Koganti B, Memon MS, Aslam Zahid MB, Shantha Kumar V, Mostafa JA. Fecal Microbiota Transplant in Recurrent Clostridium Difficile Infections: A Systematic Review. Cureus. 2022 May 5;14(5):e24754. doi: 10.7759/cureus.24754. PMID: 35693372; PMCID: PMC9174020.
• Porcari S, Baunwall SMD, Occhionero AS, Ingrosso MR, Ford AC, Hvas CL, Gasbarrini A, Cammarota G, Ianiro G. Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: A systematic review and meta-analysis. J Autoimmun. 2023 Dec;141:103036. doi: 10.1016/j.jaut.2023.103036. Epub 2023 Apr 23. PMID: 37098448.
• Lerner A, Shoenfeld Y, Matthias T. Probiotics: If It Does Not Help It Does Not Do Any Harm. Really? Microorganisms. 2019 Apr 11;7(4):104. doi: 10.3390/microorganisms7040104. PMID: 30979072; PMCID: PMC6517882.
• Nel Van Zyl K, Matukane SR, Hamman BL, Whitelaw AC, Newton-Foot M. Effect of antibiotics on the human microbiome: a systematic review. Int J Antimicrob Agents. 2022 Feb;59(2):106502. doi: 
• Lerner A, Shoenfeld Y, Matthias T. Probiotics: If It Does Not Help It Does Not Do Any Harm. Really? Microorganisms. 2019 Apr 11;7(4):104. doi: 10.3390/microorganisms7040104. PMID: 30979072; PMCID: PMC6517882.
• Pomares Bascuñana RÁ, Veses V, Sheth CC. Effectiveness of fecal microbiota transplant for the treatment of Clostridioides difficile diarrhea: a systematic review and meta-analysis. Lett Appl Microbiol. 2021 Aug;73(2):149-158. doi: 10.1111/lam.13486. Epub 2021 May 8. PMID: 33864273.
• Eliaz I. The Failure of Probiotics-and the Strategy of Microbiome Synergy. Integr Med (Encinitas). 2020 Jun;19(3):8-10. PMID: 33132772; PMCID: PMC7572142.
• Chandrasekaran P, Weiskirchen S, Weiskirchen R. Effects of Probiotics on Gut Microbiota: An Overview. Int J Mol Sci. 2024 May 30;25(11):6022. doi: 10.3390/ijms25116022. PMID: 38892208; PMCID: PMC11172883.10.1016/j.ijantimicag.2021.106502. Epub 2021 Dec 18. PMID: 34929293.
• Ramirez J, Guarner F, Bustos Fernandez L, Maruy A, Sdepanian VL, Cohen H. Antibiotics as Major Disruptors of Gut Microbiota. Front Cell Infect Microbiol. 2020 Nov 24;10:572912. doi: 10.3389/fcimb.2020.572912. PMID: 33330122; PMCID: PMC7732679.
• Éliás AJ, Barna V, Patoni C, Demeter D, Veres DS, Bunduc S, Erőss B, Hegyi P, Földvári-Nagy L, Lenti K. Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: a systematic review and meta-analysis. BMC Med. 2023 Jul 19;21(1):262. doi: 10.1186/s12916-023-02961-0. PMID: 37468916; PMCID: PMC10355080.
• Hoang DM, Levy EI, Vandenplas Y. The impact of Caesarean section on the infant gut microbiome. Acta Paediatr. 2021 Jan;110(1):60-67. doi: 10.1111/apa.15501. Epub 2020 Aug 11. PMID: 33405258.
• Renz-Polster H, David MR, Buist AS, Vollmer WM, O'Connor EA, Frazier EA, Wall MA. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy. 2005 Nov;35(11):1466-72. doi: 10.1111/j.1365-2222.2005.02356.x. PMID: 16297144.
• Bager P, Wohlfahrt J, Westergaard T. Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin Exp Allergy. 2008 Apr;38(4):634-42. doi: 10.1111/j.1365-2222.2008.02939.x. Epub 2008 Feb 11. PMID: 18266879.
• Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008 Apr;38(4):629-33. doi: 10.1111/j.1365-2222.2007.02780.x. PMID: 18352976.
• Salas Garcia MC, Yee AL, Gilbert JA, Dsouza M. Dysbiosis in Children Born by Caesarean Section. Ann Nutr Metab. 2018;73 Suppl 3:24-32. doi: 10.1159/000492168. Epub 2018 Jul 24. PMID: 30041170

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In deze aflevering:
💉 Rimpels komen doordat je schedel krimpt
📆 Preventief botox prikken helpt tegen rimpels
🤕 Botox helpt bij migraine
☠️ Botox is gif

Tom stelt de vragen, Alexander fileert de feiten. Zodat jij voortaan weet: wat is verstandig, wat is onnodig, en wanneer moet je vooral niet met je gezicht naar de goedkoopste aanbieder rennen.

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🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier:

• Wu Y, Ehlert B, Metwally AA, Perelman D, Park H, Brooks AW, Abbasi F, Michael B, Celli A, Bejikian C, Ayhan E, Lu Y, Lancaster SM, Hornburg D, Ramirez L, Bogumil D, Pollock S, Wong F, Bradley D, Gutjahr G, Rangan ES, Wang T, McGuire L, Venkat Rangan P, Ræder H, Shipony Z, Lipson D, McLaughlin T, Snyder MP. Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology. Nat Med. 2025 Jul;31(7):2232-2243. doi: 10.1038/s41591-025-03719-2. Epub 2025 Jun 4. PMID: 40467897; PMCID: PMC12283382.
• Song J, Oh TJ, Song Y. Individual Postprandial Glycemic Responses to Meal Types by Different Carbohydrate Levels and Their Associations with Glycemic Variability Using Continuous Glucose Monitoring. Nutrients. 2023 Aug 13;15(16):3571. doi: 10.3390/nu15163571. PMID: 37630761; PMCID: PMC10459284.
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• Klimontov VV, Saik OV, Korbut AI. Glucose Variability: How Does It Work? Int J Mol Sci. 2021 Jul 21;22(15):7783. doi: 10.3390/ijms22157783. PMID: 34360550; PMCID: PMC8346105.
• Belli M, Bellia A, Sergi D, Barone L, Lauro D, Barillà F. Glucose variability: a new risk factor for cardiovascular disease. Acta Diabetol. 2023 Oct;60(10):1291-1299. doi: 10.1007/s00592-023-02097-w. Epub 2023 Jun 21. PMID: 37341768; PMCID: PMC10442283.
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  Weickert MO, Pfeiffer AFH. Impact of Dietary Fiber Consumption on Insulin Resistance and the Prevention of Type 2 Diabetes. J Nutr. 2018 Jan 1;148(1):7-12. doi: 10.1093/jn/nxx008. PMID: 29378044.
  
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  Basturk B, Koc Ozerson Z, Yuksel A. Evaluation of the Effect of Macronutrients Combination on Blood Sugar Levels in Healthy Individuals. Iran J Public Health. 2021 Feb;50(2):280-287. doi: 10.18502/ijph.v50i2.5340. PMID: 33747991; PMCID: PMC7956086.
  
  Tiwari R, Tam DNH, Shah J, Moriyama M, Varney J, Huy NT. Effects of sleep intervention on glucose control: A narrative review of clinical evidence. Prim Care Diabetes. 2021 Aug;15(4):635-641. doi: 10.1016/j.pcd.2021.04.003. Epub 2021 Apr 10. PMID: 33849816.
  
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  Ghusn W, Naik R, Yibirin M. The Impact of Artificial Sweeteners on Human Health and Cancer Association: A Comprehensive Clinical Review. Cureus. 2023 Dec 29;15(12):e51299. doi: 10.7759/cureus.51299. PMID: 38288206; PMCID: PMC10822749.Qin L, Yu Y, Yu R. Artificially sweetened beverages do not influence metabolic risk factors: a systematic review and meta-analysis. Front Nutr. 2025 May 9;12:1482719. doi: 10.3389/fnut.2025.1482719. PMID: 40416387; PMCID: PMC12098100.
  
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Iedereen wil een strakkere huid, maar wat werkt nu écht tegen huidveroudering? Tom test microneedling, oftewel heel veel kleine naaldjes in z’n gezicht en Alexander duikt in de wetenschap achter de populairste huidclaims.
Van LED-maskers tot collageen-supplementen: wat is bewezen effectief, en wat vooral dure onzin?
In deze aflevering:

•  Infraroodlicht en LED: zorgt het echt voor een strakkere huid?
•  Collageen supplementen, helpt het van binnenuit?
•  Microneedling: marteling of miraculeus?
•  En: krijg je van stress echt sneller rimpels?

Tom voelt het aan den lijve, Alexander checkt de wetenschap. Alles om te ontdekken wat je huid écht jong houdt, zonder filter.
Het antwoord hoor je in aflevering 5 van Lang Zal Je Leven.
🎧Geproduceerd door Tonny Media
👉Volg ons op Instagram, TikTok en YouTube
🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier:

• Myung SK, Park Y. Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Med. 2025 Sep;138(9):1264-1277. doi: 10.1016/j.amjmed.2025.04.034. Epub 2025 May 3. PMID: 40324552.
• Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, Chen C. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023 Apr 26;15(9):2080. doi: 10.3390/nu15092080. PMID: 37432180; PMCID: PMC10180699.
• Jaiswal S, Jawade S. Microneedling in Dermatology: A Comprehensive Review of Applications, Techniques, and Outcomes. Cureus. 2024 Sep 23;16(9):e70033. doi: 10.7759/cureus.70033. PMID: 39449889; PMCID: PMC11499218.
• Oizumi, R., Kaku, H., Higuchi, N., Kawabata, F., & Sugasawa, K. (2024). The Potential of Exercise on Lifestyle and Skin Function. International Journal of Environmental Research and Public Health, 21(6), Article 79338. https://pmc.ncbi.nlm.nih.gov/articles/PMC10979338/
  
  
• Nishikori, S., Tominaga, M., Yuki, T., Yamashita, M., Ohta, Y., & Morita, A. (2023). Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrix. Scientific Reports, 13, Article 37207. https://doi.org/10.1038/s41598-023-37207-9
  
  
• Li, F., Li, S., & Xie, H. (2025). The Effects of Physical Activity on Skin Health: A Narrative Review. Clinical, Cosmetic and Investigational Dermatology, 15, 2189–2200. https://www.dovepress.com/the-effects-of-physical-activity-on-skin-health-a-narrative-review-peer-reviewed-fulltext-article-CCID
  
  
• Khatri, M., Naughton, R., Ortega-Perez, R., et al. (2021). The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery: A systematic review of randomized controlled trials. Nutrients, 13(9), 3229. https://pmc.ncbi.nlm.nih.gov/articles/PMC8521576/
  
  
• Sheppard, R., Sladden, M., & Sullivan, T. (2024). Increased physical activity promotes skin clearance, improves cardiovascular and psychological health, and increases functional capacity in patients with psoriasis. Skin Health and Disease, 4(1), e426. https://onlinelibrary.wiley.com/doi/full/10.1002/ski2.426
  
  
• Kastella, F., Riyahi, P., Sato, Y., & Nedachi, T. (2024). Potential mechanisms of exercise in maintaining skin integrity: A narrative review. World Academy of Sciences Journal, 6(3), 27-39. https://www.spandidos-publications.com/10.3892/wasj.2024.235
  
  
• Crane, J. D., MacNeil, L. G., Lally, J. S., et al. (2015). Exercise stimulates IL-15 production and preserves mitochondrial function in aging skin. Aging Cell, 14(2), 207-215.
  
  
• Ishiuchi-Sato, Y., & Nedachi, T. (2021). Muscle contraction and skin collagen synthesis: Reducing dermal CXCL10 to stimulate collagen in mouse models. Experimental Gerontology, 145, 111215.
  
  
• Medycyna Środowiskowa. (2024). Fit body, fit skin – the multifaceted effects of physical activity. Environmental Medicine, 27(1), 33-40. https://www.environmed.pl/pdf-178481-102011?filename=Sprawne+cialo_+sprawna.pdf
  
  
• Guan, L. L., Lim, H. W., & Mohammad, T. F. (2021). Sunscreens and Photoaging: A Review of Current Literature. American Journal of Clinical Dermatology, 22(5), 813-828. https://pmc.ncbi.nlm.nih.gov/articles/PMC8361399/
  
  
• Hughes, M. C., Williams, G. M., & Baker, P. (2013). Sunscreen and prevention of skin aging: A randomized trial. Annals of Internal Medicine, 158(11), 781–790.
  
  
• Liu, L., & Han, R. (2023). Advances in Relationship Between Alcohol Consumption and Skin Diseases. Journal of Clinical and Aesthetic Dermatology, 16(12), 45-51. https://pmc.ncbi.nlm.nih.gov/articles/PMC10759914/
  
  
• Patel, S., & Prasad, S. (2024). A Decade of Evidence Linking Sleep Quality to Dermatologic Outcomes: An Integrative Review. American Journal of Dermatology, 8(6), 15-32. https://www.arcjournals.org/pdfs/ajd/v8-i6/2.pdf
• Chen, Y., & Lyga, J. (2023). Brain–Skin Connection: Stress, Inflammation and Skin Aging. Dermato-Endocrinology, 15(1), e2181133.

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🔥 Sauna (infrarood) helpt met spierherstel
💧 Afvallen en detoxen door zweten
🧠 Sauna verkleint de kans op dementie en Alzheimer
❤️ Sauna is goed voor je hartgezondheid

Het antwoord hoor je in aflevering 4 van Lang Zal Je Leven.

🎧 Geproduceerd door Tonny Media
👉 Volg ons op Instagram, TikTok en YouTube
🥼 Alle onderzoeken die in deze aflevering worden besproken vind je hier:

• Laukkanen T, Kunutsor SK, Zaccardi F, Lee E, Willeit P, Khan H, Laukkanen JA. Acute effects of sauna bathing on cardiovascular function. J Hum Hypertens. 2018 Feb;32(2):129-138. doi: 10.1038/s41371-017-0008-z. Epub 2017 Dec 21. PMID: 29269746.
• Laukkanen T, Khan H, Zaccardi F, Laukkanen JA. Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Intern Med. 2015 Apr;175(4):542-8. doi: 10.1001/jamainternmed.2014.8187. PMID: 25705824.
• Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA. Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men. Age Ageing. 2017 Mar 1;46(2):245-249. doi: 10.1093/ageing/afw212. PMID: 27932366.
• Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study. BMC Med. 2018 Nov 29;16(1):219. doi: 10.1186/s12916-018-1198-0. PMID: 30486813; PMCID: PMC6262976.
• Kunutsor SK, Khan H, Zaccardi F, Laukkanen T, Willeit P, Laukkanen JA. Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study. Neurology. 2018 May 29;90(22):e1937-e1944. doi: 10.1212/WNL.0000000000005606. Epub 2018 May 2. PMID: 29720543.
• Imamura, M, Biro, S, Kihara, T. et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. JACC. 2001 Oct, 38 (4) 1083–1088. https://doi.org/10.1016/S0735-1097(01)01467-X
• Lee E, Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna exposure leads to improved arterial compliance: Findings from a non-randomised experimental study. Eur J Prev Cardiol. 2018 Jan;25(2):130-138. doi: 10.1177/2047487317737629. Epub 2017 Oct 19. PMID: 29048215.
• Kunutsor, S. K., Khan, H., Laukkanen, T., & Laukkanen, J. A. (2017). Joint associations of sauna bathing and cardiorespiratory fitness on cardiovascular and all-cause mortality risk: a long-term prospective cohort study. Annals of Medicine, 50(2), 139–146. https://doi.org/10.1080/07853890.2017.1387927
• Knekt P, Järvinen R, Rissanen H, Heliövaara M, Aromaa A. Does sauna bathing protect against dementia? Prev Med Rep. 2020 Oct 2;20:101221. doi: 10.1016/j.pmedr.2020.101221. PMID: 33088678; PMCID: PMC7560162.
• Kunutsor SK, Jae SY, Laukkanen JA. Frequent sauna bathing offsets the increased risk of death due to low socioeconomic status: A prospective cohort study of middle-aged and older men. Exp Gerontol. 2022 Oct 1;167:111906. doi: 10.1016/j.exger.2022.111906. Epub 2022 Jul 28. PMID: 35908583.
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• Hayasaka S, Nakamura Y, Kajii E, Ide M, Shibata Y, Noda T, Murata C, Nagata K, Ojima T. Effects of charcoal kiln saunas (Jjimjilbang) on psychological states. Complement Ther Clin Pract. 2008 May;14(2):143-8. doi: 10.1016/j.ctcp.2007.12.004. Epub 2008 Mar 4. PMID: 18396259.
• Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R. Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial. BMC Complement Altern Med. 2017 Mar 28;17(1):172. doi: 10.1186/s12906-017-1676-5. PMID: 28351399; PMCID: PMC5371197.
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In deze aflevering bespreken ze:

• Helpt koffie écht tegen vermoeidheid?
• Hoeveel koppen koffie zijn goed voor je, en waarom is de timing belangrijk?
• Is koffie goed voor afvallen en je hartgezondheid?
• Droogt het je uit, en klopt het dat het je stresshormoon omhoog jaagt?

Tom test het in de praktijk, Alexander checkt de wetenschap.

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Onderzoeken die Alexander heeft gebruik voor deze aflevering: 

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Ze factchecken de populairste eiwitclaims:

• Moet je direct na het sporten eten vanwege het anabolic window?
• Hoeveel gram eiwit heb je nodig per kilo lichaamsgewicht?
• Helpt eiwit eten bij vetverlies?
• En is vegetarisch eten echt minder effectief dan vlees?

Tom test het in de praktijk, Alexander checkt de wetenschap.

🗣️ Waar zoek jij naar steun? Als grootste online therapieplatform ter wereld biedt Betterhelp toegang tot deskundige therapeuten. Luisteraars van deze podcast krijgen 10% korting op de eerste maand via www.betterhelp.com/langzaljeleven 

🎧 Geproduceerd door Tonny Media
👉 Volg ons op Instagram, TikTok en YouTube
🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier:

• Morton RW, Murphy KT, McKellar SR, Schoenfeld BJ, Henselmans M, Helms E, Aragon AA, Devries MC, Banfield L, Krieger JW, Phillips SM. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018 Mar;52(6):376-384. doi: 10.1136/bjsports-2017-097608. Epub 2017 Jul 11. Erratum in: Br J Sports Med. 2020 Oct;54(19):e7. doi: 10.1136/bjsports-2017-097608corr1. PMID: 28698222; PMCID: PMC5867436.
• Nunes EA, Colenso-Semple L, McKellar SR, Yau T, Ali MU, Fitzpatrick-Lewis D, Sherifali D, Gaudichon C, Tomé D, Atherton PJ, Robles MC, Naranjo-Modad S, Braun M, Landi F, Phillips SM. Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults. J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):795-810. doi: 10.1002/jcsm.12922. Epub 2022 Feb 20. PMID: 35187864; PMCID: PMC8978023.
• Tagawa R, Watanabe D, Ito K, Otsuyama T, Nakayama K, Sanbongi C, Miyachi M. Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials. Sports Med Open. 2022 Sep 4;8(1):110. doi: 10.1186/s40798-022-00508-w. PMID: 36057893; PMCID: PMC9441410.
• Santini MH, Erwig Leitão A, Mazzolani BC, Smaira FI, de Souza MSC, Santamaria A, Gualano B, Roschel H. Similar effects between animal-based and plant-based protein blend as complementary dietary protein on muscle adaptations to resistance training: findings from a randomized clinical trial. J Int Soc Sports Nutr. 2025 Dec;22(1):2568047. doi: 10.1080/15502783.2025.2568047. Epub 2025 Oct 8. PMID: 41059835; PMCID: PMC12509290.
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• Hudson JL, Iii REB, Campbell WW. Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept? Nutrients. 2020 May 16;12(5):1441. doi: 10.3390/nu12051441. PMID: 32429355; PMCID: PMC7285146.
• Møller G, Rikardt Andersen J, Ritz C, P Silvestre M, Navas-Carretero S, Jalo E, Christensen P, Simpson E, Taylor M, Martinez JA, Macdonald I, Swindell N, Mackintosh KA, Stratton G, Fogelholm M, Larsen TM, Poppitt SD, Dragsted LO, Raben A. Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study. Nutrients. 2018 Jan 9;10(1):54. doi: 10.3390/nu10010054. PMID: 29315212; PMCID: PMC5793282.
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• Kokura Y, Ueshima J, Saino Y, Maeda K. Enhanced protein intake on maintaining muscle mass, strength, and physical function in adults with overweight/obesity: A systematic review and meta-analysis. Clin Nutr ESPEN. 2024 Oct;63:417-426. doi: 10.1016/j.clnesp.2024.06.030. Epub 2024 Jun 24. PMID: 39002131.
• Guarneiri LL, Adams CG, Garcia-Jackson B, Koecher K, Wilcox ML, Maki KC. Effects of Varying Protein Amounts and Types on Diet-Induced Thermogenesis: A Systematic Review and Meta-Analysis. Adv Nutr. 2024 Dec;15(12):100332. doi: 10.1016/j.advnut.2024.100332. Epub 2024 Oct 31. PMID: 39486625; PMCID: PMC11625215.

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Helpt het bij spierherstel na het sporten, versterkt het je immuunsysteem, verhoogt het je dopamine, en kun je er zelfs van afvallen?  Of is het vooral een koude hype die lekker klinkt op TikTok?
Tom test het zelf, Alexander checkt de wetenschap.

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• Espeland, D., de Weerd, L., & Mercer, J. B. (2022). Health effects of voluntary exposure to cold water – a continuing subject of debate. International Journal of Circumpolar Health, 81(1). https://doi.org/10.1080/22423982.2022.2111789

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