The Lab Report

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Attitude of Gratitude [Rebroadcast]

Tue, 25 Nov 2025 12:00:00 +0000

The Thanksgiving holiday is more than just family, friends, food, and football. It is an opportunity to be reminded of the importance of gratitude. Although being thankful seems like just a nice moral platitude, gratitude interventions are shown to have surprisingly important clinical implications for our health.

On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain.

Today on The Lab Report:

3:10 Fun facts about Thanksgiving
7:35 Gratitude interventions and health

11:15 Strategies to prevent holiday weight gain
14:30 Keto, Vegan, Carnivore, Omnivore holiday dinner menus
16:45 Kitchen Cook-cophany!

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The Migrating Motor Complex

Wed, 19 Nov 2025 18:34:00 +0000

Gut motility may be the most important and least discussed aspect of health. One vital part of gut motility is the Migrating Motor Complex. The Migrating Motor Complex (MMC) is the gut’s “street sweeper,” clearing food and bacteria to maintain intestinal homeostasis between meals. In this episode, we review its physiology, regulatory mechanisms, and clinical relevance – from SIBO to functional GI disorders – highlighting why this cyclical motility pattern matters for patient care.

Today you’ll meet the migrating motor complex: your gut’s built-in street sweeper that clocks in when you’re not eating. This behind-the-scenes cleaning cycle is essential to GI health!

Today on The Lab Report:

3:20 Gut motility – peristalsis and segmentation
5:45 Migrating Motor Complex (MMC)
8:40 Motilin, serotonin, and the vagus nerve
11:15 Acidification of the small intestine and Motilin
13:25 Signaling the vagus nerve
16:20 MMC’s role in SIBO/IMO
17:50 Prokinetics and meal spacing
22:00 Question of the Day
- What is the relationship between PPI’s and MMC?

Additional Resources:

SIBO Breath Test

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Is Butyrate the Best Microbiome Product?

Tue, 11 Nov 2025 12:00:00 +0000

The microbiome continues to be viewed as a cornerstone of health, whether we are discussing the gastrointestinal tract, cardiovascular risk, immune dysfunction, and even cognitive health. One major contributions of the microbiome to our global health is in the production of short-chain fatty acids. Primary among these products is a compound known as n-butyrate. N-butyrate has profound roles, not only in our gut, but throughout our entire body. What are all the impacts of n-butyrate, and how do we foster an adequate supply of it? These are but some of the questions we discuss on today’s Lab Report.

In this episode, we continue our spree on the importance of gut health. We cover food sources that are important for microbiome health, particularly for fermentation of short-chain fatty acids. We also cover how butyrate impacts the gut, the immune system, and much more. With all the profound roles of n-butyrate, it begs the question: is it the greatest of all the things made by our microbiome?

Today on The Lab Report:

5:30 Gut microbiome production of SCFA’s (short-chain fatty acids)
6:30 Food sources of n-butyrate
8:00 Let’s Google It: The entomology of ‘butyrate’
9:00 Butyrogenic species: What bacteria produce butyrate?
10:45 How butyrate is used throughout the body
13:00 Logical Speculation: n-butyrate, autoimmunity, and fiber
15:45 The gut-brain axis and appetite are influenced by butyrate
20:30 Skeletal muscle also responds to butyrate
23:30 Foods to eat to promote butyrate
26:00 N-Butyrate supplementation: mixed studies?

Additional Resources:

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Dysbiosis: The Moving Target

Thu, 23 Oct 2025 10:12:41 +0000

Based on recent research, the term ‘dysbiosis’ is no longer a simple black-and-white diagnosis of a gut imbalance. The scientific understanding of a healthy microbiome is evolving. It’s no longer just about the laundry list of organisms present, but rather about their functionality for health and disease.

In today’s episode, we unpack the term ‘dysbiosis.’ Join us to rethink what it means to have a healthy microbiome, the utility of novel algorithmic scoring, and how a deeper understanding of this complex ecosystem is opening doors to more targeted diagnostics and therapeutics.

Today on The Lab Report:

4:30 Healthy microbiome vs. Dysbiosis
8:00 Defining terms
10:10 Dysbiosis scoring algorithms
15:40 Functional approach to dysbiosis
16:30 Rethinking pathogens
19:25 The microbiome is reactionary – root cause is important!
23:15 Should we even be using the word “dysbiosis”?
24:25 Whole genome sequencing and gut functionality
28:00 Adaptability of the microbiome

Additional Resources:

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What's a Stool Test Really For?

Sat, 11 Oct 2025 10:00:00 +0000

Like Hippocrates said, “All Disease Begins in the Gut.” Here in functional/personalized medicine, stool testing is an important tool to help get to the root cause of chronic conditions or to optimize health. Given its vital role in clinical practice, choosing the right stool test becomes paramount and being mindful of the information you are seeking is key.

In today’s episode, we're taking the conversation deeper, refocusing on why studying the microbiome is so critical. This episode redefines the clinical utility of Genova's stool tests, giving you the insights you need to make informed decisions and get better results for your patients.

Today on The Lab Report:

4:55 Stool testing - High-level why’s
8:00 Clinical guide to basic gut function
11:00 Inflammation biomarker overload
13:30 Measuring maldigestion/malabsorption
16:15 Gut metabolites – direct vs. Next-Gen Sequencing
20:10 Infection – bacterial culture
24:45 Finding parasites

Additional Resources:

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Heat Shock Proteins are a Thing

Tue, 23 Sep 2025 11:00:00 +0000

Heat Shock Proteins (HSPs) are often called molecular chaperones. These crucial proteins spring into action when cells are under threat from environmental stressors, toxins, inflammation, and oxidative stress.

Join us as we uncover how heat shock proteins function as the cell’s microscopic repair crew. Discover how this fundamental biological mechanism not only protects our cells from daily stresses but also holds promising clues to treating age-related illnesses like cancer and neurodegenerative diseases.

Today on The Lab Report:

3:50 Heat shock proteins and cellular health
8:05 Types of cellular stress
9:30 Specific functions of HSPs
11:00 Metaphors are fun
13:05 How were these discovered?
14:00 Different than cold shock proteins
16:00 Clinical associations in disease
19:15 Naturally increasing your HSPs
21:25 Drug development and implications

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Licorice Root - The Great Synergizer

Tue, 09 Sep 2025 12:04:57 +0000

Licorice root is a time-honored herbal remedy with a sweet side. Beyond its role in teas and tonics, licorice root has been used for centuries to support digestion, ease respiratory illnesses, and calm everyday inflammation. It is well- known for its synergistic effects with other herbal therapies.

Join us as we talk about how licorice root can fit into your wellness routine, the traditions behind its medicinal use, and simple ways you can explore these benefits safely.

Today on The Lab Report:

4:00 Licorice root – the plant, not the candy
7:15 Powerhouse synergizer herb
9:45 Bioactive constituents – pharmacologic overview
13:45 Clinical uses – starting with the respiratory tract
16:40 Google it – Dental caries
19:15 In vitro cancer studies
21:30 Estrogenic activities
23:22 Cortisol, fluid retention, electrolytes, blood pressure
25:45 “What’s in a Name?”

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Mitochondrial Dysfunction - The Cell as a City

Thu, 14 Aug 2025 11:00:00 +0000

Mitochondrial dysfunction may be one of the most important topics in the area of personalized and preventative medicine to date. Thousands of articles have been published on the nature of how mitochondria become damaged and what that means for health, longevity, and aging. On today’s podcast, we take a deep dive into the triggers for mitochondrial dysfunction and what clinical conditions are related to damaged mitochondria.

We also discuss how to arm your arsenal with everyday items to help stability, protect, and maintain our mitochondria. We also discuss how other systems within and outside the cell are impacted by these “power plants” within.

Today on The Lab Report:

3:45 Break it down: the parts of the cell
8:40 The mitochondria are power plants
9:00 What’s normal?
10:00 Factors that trigger mitochondrial dysfunction
13:20 The mitochondria as our cell’s cohabitant
16:10 Progression of mitochondrial dysfunction
20:10 Clinical conditions associated with mitochondrial dysfunction
21:00 What can we do about it?

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The #1 Complete Protein

Thu, 24 Jul 2025 11:00:00 +0000

Eggs are one of the most widely-consumed, and underappreciated, foods in the human diet. Long regarded as a nutritional powerhouse, eggs are rich in high-quality protein and essential nutrients that are key for health. In fact, eggs are considered the best complete protein – meaning they contain all 9 essential amino acids. But for decades, eggs were caught in the crossfire of the cholesterol debate.

In today’s episode, we’ll explore what current research says about the relationship between eggs and heart health, and whether concerns about dietary cholesterol still hold up. We’ll also discuss the role of eggs in weight management, muscle maintenance, eye health, and brain function. Whether you’re someone who eats eggs daily or has questions about whether you should, this episode offers a thoughtful, evidence-based discussion on why eggs have earned their place at the table.

Today on The Lab Report:

4:00 Why can't we agree about eggs?
6:00 Eggs are low calorie and a complete protein
8:30 Which is better the whites or the yolks?
10:00 Eggs, choline, and brain health
11:45 Eggs and eyes
17:00 The egg and cholesterol controversy
19:45 We find a way to bring "methylation" into the discussion
23:00 Eggs, satiety, and weight management
24:50 Little known constituents inside eggs
26:30 Other types of eggs and their nutritional value
29:00 Fun facts about eggs: color and bloom
30:20 Which came first, the chicken or the egg?

We also referenced The Methylation Episode which can be listened to here.

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Is Shotgun Sequencing Better Than PCR?

Wed, 16 Jul 2025 12:24:01 +0000

Stool testing technology has advanced rapidly in recent years, with newer methods like PCR and whole-genome sequencing offering faster and more precise insights into the gut microbiome. These innovations have transformed how clinicians approach gut health, allowing for more targeted interventions. However, older technologies—such as microscopy, culture, and enzyme-based assays—still play a valuable role. These methods provide functional insights that molecular tools may miss, such as direct observation of parasites or assessment of digestive markers. The most comprehensive labs recognize that no single method gives the full picture. Instead, combining the strengths of both modern and traditional techniques ensures more accurate, clinically meaningful results.

In this episode, we dive into the pros and cons of different laboratory methodologies used in stool testing—from culture and microscopy to PCR and advanced sequencing. We break down how these choices impact accuracy, sensitivity, and clinical usefulness. You'll also learn why Genova Diagnostics stands out for its integrative, evidence-based approach, combining multiple testing methods to deliver the most comprehensive and clinically actionable results available.

Today on The Lab Report:

4:00 Technology grows quickly, and the microbiome is complex
7:30 Microbiology culture
12:40 PCR – very precise if done correctly!
17:00 Interpreting the laundry list
20:10 Remember the microscope?
23:30 Whole-genome (shotgun) sequencing pros/cons
27:15 Genova does it all – and well

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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NAC...Drug or Super Supplement? [Rebroadcast]

Tue, 08 Jul 2025 16:58:33 +0000

N-acetylcysteine, or NAC, plays an important role in the body when it comes to combating oxidative stress. As a precursor to make glutathione, NAC has been used for decades both as an acute medication and as an over-the-counter supplement. Recently, the line between medication and supplement has been blurred and is now being debated.

Today we talk all about N-acetylcysteine - the ways NAC is used and its importance in health and disease.

Today on The Lab Report:

2:45 NAC as a drug in acute care settings
4:00 Mechanisms of action in the lung and kidney
7:15 NAC as a daily supplement
10:00 Hmmm…so is it a medication or a supplement?
11:15 Generic drug or herbal constituent?
15:00 Research on NAC in psychiatric disorders
16:16 NAC in polycystic ovary syndrome and fertility
17:40 Safety and side effects
18:50 Question of the Day:
- What are the other precursors to glutathione and how do we measure them?

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Turmeric: The Science Behind the Spice

Tue, 01 Jul 2025 10:47:11 +0000

Turmeric is a spice with ancient origins. You’ve seen it in smoothies, teas, curry, and supplements. Known for its bright yellow color, it has been used for centuries to support whole-body wellness. From inflammation and joint pain to brain and heart health, in this episode we break down what the science says about turmeric and its main constituent curcumin.

Join us as we explore turmeric’s long-standing role in health and wellness and zoom in on curcumin. We break down what the science says about curcumin’s therapeutic potential, how it’s absorbed, and whether supplementation is worth the hype. Whether you’re a culinary enthusiast or a health-conscious listener, this discussion of turmeric promises to spice up your knowledge!

Today on The Lab Report:

4:30 The history of turmeric
7:30 Inflammation, whole root vs. curcumin
10:45 Oxidative stress, polyphenols, tumors, brain health
12:50 How much turmeric/curcumin per day
15:15 Poor absorption and bioavailability
18:20 Side effects – be aware
19:30 It stains stuff
21:50 Reputable sourcing and MC’s home recipe?

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The Ultimate Longevity Metric : VO2 Max

Tue, 24 Jun 2025 14:06:04 +0000

There’s a lot of buzz around the topic of longevity. One might argue that every aspect of functional and integrative medicine promotes longevity – which is true. We’re not merely looking to lengthen lifespan we want to promote a HEALTH span. With that in mind, data is compelling. There’s one metric that is often overlooked which happens to be the greatest predictor of longevity: VO2 max.

Join us as we dive deep into how VO2 max impacts health, longevity, and overall well-being. We’ll discuss the science, how to measure it, and how to improve this crucial fitness metric.

Today on The Lab Report:

4:15 What is VO2 max and how do we use oxygen?
6:00 Mitochondrial biogenesis, VO2 max, and the research
9:00 What’s normal?
10:45 How do you measure VO2 max?
14:10 Improving your VO2 max
17:10 Question of the Day
- How does Genova assess longevity?

Additional Resources:

Longevity Landing Page

Best for Breast Supplements

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Alpha-gal Syndrome: Tick-borne Meat Allergy?

Tue, 10 Jun 2025 10:42:09 +0000

As we enter the summer season, many of us will spend countless hours outdoors. We often discuss tick awareness and tick-borne illness, but one tick in particular is getting a lot of press these days. In case you needed another reason to be mindful of ticks, today we discuss Alpha-gal Syndrome.

In today’s episode we explore the science behind alpha-gal syndrome – a rare and serious allergy to red meat and other mammal products triggered by a bite from the Lone Star Tick. Tune in to learn how to recognize symptoms and why this syndrome is spreading across many regions and many countries.

Today on The Lab Report:

3:30 What is Alpha-gal Syndrome?
6:30 Delayed anaphylaxis? What!
9:50 Epidemiology and prevalence
11:50 Not only red meat – other products
14:55 Diagnosing alpha-gal syndrome
16:20 Tick avoidance and sensitization
18:40 What foods can these patients eat?
20: 15 Question of the Day?
- Are there herbs that can help?

Additional Resources:

Alpha-gal Information

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Tinnitus and Hearing: From Cochlea to Cortex

Tue, 27 May 2025 13:34:35 +0000

Tinnitus—the phantom ringing, buzzing, or hissing that affects millions. For those patients who suffer with this debilitating condition, it is frustrating to find any relief. For those clinicians trying to treat it, the causes are so multi-faceted, and the treatments seem to be lacking.

Today we break down the physiology of hearing, what can go wrong in the auditory system, and the many potential causes of tinnitus, from noise exposure to neurological conditions. We also examine current treatment options, emerging therapies, and what the latest research says about finding relief. Whether you're a sufferer or just curious, this episode tunes into the facts behind the noise.

Today on The Lab Report:

5:00 Tinnitus – what is it?

7:00 Physiology of hearing sound

10:30 Basic causes of tinnitus

13:45 Pathophysiology & mechanisms

17:45 Loud noise causing tinnitus

22:35 Presbycusis, ototoxicity, hearing loss

25:05 Root causes and treatment of tinnitus

28:00 Functional approach for clinicians

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Integrative Cancer Care with Dr. Laura James

Tue, 13 May 2025 10:51:59 +0000

Dr. Laura James is a board-certified naturopathic oncologist who has been working with cancer patients for over 20 years. She helps patients who are recently diagnosed with cancer get through the intense steps of conventional treatment – surgery, chemotherapy, and radiation – using natural means like nutrition, herbs, gentle movement, and stress management.

In today’s episode, we hear Dr. Laura James discuss her balanced viewpoint on the use of natural therapies in combination with conventional treatment to support cancer patients. Through supplement streamlining, nutritional and botanical recommendations, and lifestyle counseling, her expertise can help you feel better through treatment and beyond.

Today on The Lab Report:

4:00 Meet Dr. Laura James and hear how she defines integrative cancer care
9:25 Diet and nutrition – keto, fasting, low carb, protein
14:00 Working alongside conventional oncologists
19:20 Building a care team
24:00 Supporting the chemotherapy journey
27:50 Antioxidants, probiotics, and chemo
32:45 Resilience and the mental emotional rollercoaster
37:40 “Battle language” and vulnerability in cancer
43:50 Preventative care
51:30 Where to find Dr. Laura James?
53:55 The Fireball

Additional Resources:

LauraJamesND.com

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ORAC Scores: Debunking Myths and Unraveling Controversy

Tue, 06 May 2025 12:49:52 +0000

Are ORAC scores the secret to superfoods—or just marketing fluff? In this episode, we break down what ORAC (Oxygen Radical Absorbance Capacity) really measures and why it stirred up so much controversy. The USDA pulled the plug on publishing the data, but does the concept still hold any value in nutrition science today?

In today’s episode, we dive into a myth-busting conversation that explores the science of ORAC, the skepticism, and the truths about antioxidants and health.

Today on The Lab Report:

5:15 Review of oxidative stress and antioxidants
8:20 History of the ORAC assay
11:45 Limitations of the ORAC measurement
13:20 USDA vs. Supplement companies
15:30 Foods with high ORAC scores
18:55 Should we still care? What’s the future?

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Fatty Acids & Inflammation [Rebroadcast]

Thu, 24 Apr 2025 11:40:00 +0000

Inflammation is your body’s way of protecting itself from infection, injury, or other insults. Chemical signaling molecules called ‘eicosanoids’ are responsible for creating pain, heat, swelling, and redness. Eicosanoids are made from fatty acids, or dietary fats. We’ve all heard of fish oil and omega-3s being important when it comes to lowering inflammation. But why?

In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’

Today on The Lab Report:

3:20 What are eicosanoids?
6:05 Fatty acids and the inflammatory cascade
9:10 Lipoxygenase (LOX) and cyclooxygenase (COX)
10:00 The COX eicosanoids – prostanoids and thromboxane
12:10 Leukotrienes, lipoxins, resolvins, and LOX
13:15 Aspirin, fish oil, and heart disease
16:30 Question of the Day
- How should we measure fatty acids?

Additional Resources:

Essential & Metabolic Fatty Acids - Bloodspot

The omega-3 index as a risk factor for coronary heart disease

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Vitamins D & K2 : The Key to Unlocking Strong Bones

Tue, 08 Apr 2025 12:30:00 +0000

If you are worried about keeping your bones strong, there’s more to the story than taking calcium supplements. Vitamin D and vitamin K work together to support strong, healthy bones. Vitamin D helps your body absorb calcium from food, which is essential for building and maintaining bone density. But without enough vitamin K—particularly vitamin K2—that calcium might not end up where it's needed. Vitamin K2 activates proteins that help direct calcium into bones and teeth while keeping it out of soft tissues like arteries. In other words, vitamin D gets the calcium in, and vitamin K makes sure it goes to the right place.

In today’s episode, we discuss the important relationship between vitamin D and vitamin K. These 2 fat-soluble vitamins collaborate to support bone density – there’s more to bone health than calcium!

Today on The Lab Report:

4:15 Fat-soluble vitamins
6:00 Vitamin D recap
9:35 Bone remodeling
12:05 All about Vitamin K
15:50 Calcium isn’t the whole story
18:25 D3/K2 and cardiovascular health
20:15 Other factors that contribute to bone health
22:40 Question of the Day
- Do problems with fat digestion cause vitamin deficiency?

Additional Resources:

Genova Connect

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Zombie Cells

Wed, 02 Apr 2025 11:30:00 +0000

Zombie cells, scientifically known as senescent cells, are damaged or aged cells that refuse to die when they should. Instead, they linger in the body, releasing harmful chemicals that can trigger inflammation and accelerate aging. These cells have been linked to a range of age-related diseases, including arthritis, Alzheimer’s, and even cancer.

Dive into the eerie world of 'Zombie Cells' on our latest episode! Uncover how these undead cells wreak havoc in our bodies and what cutting-edge research reveals about their role in aging and disease.

Today on The Lab Report:

4:15 Cell turnover, apoptosis, and autophagy vs. zombie cells
7:30 What triggers zombie cells to form and what are telomeres?
10:15 Age-related diseases and inflammation
12:15 Senolytics and strategies to clear zombie cells
17:30 Just practice naturopathic medicine
18:30 Rules to survive a zombie apocalypse

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Why Hair Goes Grey

Tue, 25 Mar 2025 12:00:00 +0000

Such a random topic – gray hair? The technical term for hair graying is canities – again, what a strange word. Who knew? The basic physiology of hair growth and coloration is not something we really think about, but your hair can be a reflection of underlying health or disease. We often talk about the aging process as a marker of oxidative stress -So too with your hair.

In this episode, we dive into the science of graying hair. From melanin loss to genetics to some surprising lifestyle connections, we separate fact from fiction and uncover the truth about your hair.

Today on The Lab Report:

3:40 Canities, melanin and hair color
7:25 Melanin in hair vs. skin, hair growth stages
12:15 Aging and premature graying, oxidative stress
16:25 Nutrition, hormonal influences, inflammation, stress
18:20 Re-pigmentation??? Or at least delay graying
23:10 Question of the Day
- How can Genova’s testing help?

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Hiccups- How They Happen and Hacks to Halt Them

Tue, 18 Mar 2025 13:45:00 +0000

Hiccups- that annoying and at times, painful reflex that sneaks up on you when you least expect it, and sometimes refuses to leave. But what are they really? Is there an evolutionary reason we’ve developed this reflex? When should you be concerned? Can we prevent them?

In this episode, we break down the pathophysiology of hiccups (yes, there’s real science behind it) Knowing the science of why they occur, we can separate fact from fiction on how to cure them. From medical insights to strange home remedies, we’re getting to the root of the world’s most inconvenient reflex.

Today on The Lab Report:

3:45 Hiccups – the diaphragm and phrenic nerve
6:30 Pathophysiology of the hiccup and evolution of this reflex
9:30 Diet and lifestyle hiccup triggers
11:00 The rhythmic reflex arc
13:40 When should you be concerned?
15:50 Common cures – fact vs. fiction
21:25 Traditional Chinese Medicine and Charles Osborne
23:09 Take-aways for functional medicine practitioners

Additional Resources:

Genova Connect

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Optimizing Akkermansia with Christina O'Connor

Tue, 11 Mar 2025 12:45:00 +0000

Akkermansia muciniphila has been getting tons of great press recently. It’s a bacterium in the gut microbiome that thrives by supporting mucin production. However, its potential to enhance metabolic health and support weight management has paved the way for innovative probiotic solutions – which is exactly what a company called Pendulum has done! Pendulum’s products are backed by cutting-edge research showing clinical efficacy.

Today we speak with Christina O’Connor, registered dietician and Senior Healthcare Account Manager at Pendulum Therapeutics. Christina breaks down all the latest research on Akkermansia muciniphila and how optimizing levels can lead to greater health outcomes.

Today on The Lab Report:

5:30 Christina O’Connor on her love of microbiome science
8:40 Main drivers of gut health
10:15 Why should we care about Akkermansia?
13:05 Can you have too much?
15:20 GLP-1 effects of Akkermansia
17:25 Stool testing on probiotics and supporting colonization
22:40 What’s next for Pendulum?
24:15 The Fireball

Additional Resources:

Pendulum Discount Codes:

Healthcare professionals: Create a provider account HERE for wholesale pricing and get $50 off with code WSGENOVA50.

Not a healthcare professional or just want to try it out? Get 20% off your first membership order at pendulumlife.com with code GENOVA at checkout.

Genova Connect Discount Code:

Are you a consumer interested in checking your levels of Akkermansia? Use the promo code PENDULUM20 for 20% off Genova Diagnostics’ Akkermansia Assessment

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Root Cause Medicine and Testing in Kids

Wed, 05 Mar 2025 11:00:00 +0000

Advanced technologies and personalized approaches have been the hallmark of what we do here at Genova Diagnostics. We are frequently asked how this testing can be applied in pediatrics. Our testing is widely used to help empower parents to get to the root cause of some common childhood concerns. But there are some caveats to consider when interpreting results.

Every child is unique – so why shouldn’t their healthcare be? In this episode, we dive into the world of personalized medicine for children and how Genova’s cutting-edge testing can unlock better health outcomes for kids.

Today on The Lab Report:

3:25 Approaching common pediatric ailments
6:00 Root causes of skin issues, rashes, eczema
9:15 Food Sensitivity Testing and caveats
11:00 Stool testing in pediatrics – interp is different!
15:15 Pediatric nutrition testing – benefits and things to know
17:40 Childhood obesity and testing for metabolic syndrome
20:00 “What is it?” Game

Additional Resources:

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Dr. Rick Johnson & Neil Gyte on Appetite, Chronic Disease, and the Damaging Impact of Sugar

Tue, 25 Feb 2025 11:00:00 +0000

We all know sugar isn’t great for our health. But is all sugar created equal? In this eye-opening podcast, we speak with the team from RxSugar. Their company creates and promotes a healthy sugar called allulose. Yes, a healthy sugar!

Dr. Rick Johnson is a leading researcher on the hidden dangers of sugar. He discusses the impact of how sugar and fructose can hijack your cravings, fuel inflammation, and contribute to chronic disease. We also meet former Google Exec Neil Gyte. His personal journey toward metabolic health found him crossing paths with the science team at RxSugar. Neil joined their company and now continues his mission to make 1 billion people world-wide metabolically healthy while promoting the benefits of allulose. Listen in and enjoy this fascinating conversation!

Today on The Lab Report:

5:10 Meet Dr. Richard Johnson and Neil Gyte
7:00 Fructose, appetite, and leptin resistance
14:25 Sugar industry and sub-optimal clinical trials
22:15 Fructose, carbs and the polyol pathway, uric acid levels
29:40 Neil’s a-ha moments toward metabolic health
34:00 Joining RxSugar -Allulose as a game-changer
41:40 Other artificial sweeteners
46:40 Allulose and the ketogenic diet
49:30 1BMH and diet/lifestyle factors
54:25 1BMH vision and the Loch Lomond swim
59:35 Where you can learn more!
1:02.10 The Fireball

Additional Resources:

RxSugar.com **PROMO CODE 1BMH for 20% Discount!*** (expires in June)

YouTube Videos

Published Papers:

Microbiome

Fructose & Metabolic Syndrome

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Garlic! - Nature's Secret Weapon

Sat, 15 Feb 2025 11:00:00 +0000

Garlic isn't just a kitchen staple—it’s a natural powerhouse of health benefits! Packed with antioxidants and sulfur compounds like allicin, garlic supports heart health by lowering blood pressure and cholesterol, strengthens the immune system, fights inflammation, and so much more. With its antibacterial and antiviral properties, garlic has been used for centuries as a natural remedy for colds, infections, and overall wellness.

Whether eaten raw, cooked, or taken as a supplement, garlic is a simple yet powerful way to boost your health naturally. Join us as we discuss this unsung herbal hero.

Today on The Lab Report:

3:00 Garlic is a vegetable and a medicine
7:30 Herbal constituents vs. whole plants
9:00 Allicin
11:50 Cardiovascular health and immunity
14:20 Antimicrobial and antiviral properties
15:20 Garlic is useful in so many clinical conditions
17:20 Which form is best?
19:25 Get Outta Here!!!!!!!!

Additional Resources:

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The Roseto Effect

Tue, 04 Feb 2025 11:00:00 +0000

Longevity isn’t about adding years to your life- it’s about adding life to your years! We know there are many variables to health such as diet, movement, sleep, social connection, fresh air and sunlight. Each are important but some aren’t easily measured.

The Roseto Effect reveals the surprising power of tight-knit communities, social bonds, and old-world traditions in shaping our health. Join us as we tell the story of a small town in Pennsylvania called Roseto. Can community be the ultimate medicine?

Today on The Lab Report:

3:20 The story of Roseto
10:35 Parallels to the Blue Zones
13:20 Can you measure the effects of community?
14:40 Longevity – quantity vs. quality
16:50 Back to the basics for health
19:00 How to develop social connection

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Laryngitis - Voice on Vacation

Wed, 22 Jan 2025 11:00:00 +0000

Ever wonder what happens when your voice suddenly decides to take a vacation? In this episode, we explore the mysterious condition of laryngitis. From causes to symptoms, we can help you discover the best ways to recover and protect your voice.

Whether you're dealing with laryngitis now or just curious about how it works, this episode will give you the answers you need. Tune in for all the insights into a silent struggle!

Today on The Lab Report:

2:50 Patti lost her voice so we’re covering laryngitis
4:05 The anatomy of the voice box and power of speech
6:00 Laryngitis, symptoms and causes
8:25 Let’s go Woo – Throat chakra!
12:20 Disclaimer on not missing more serious causes
13:00 Treatment options
15:25 Herbal remedies
18:55 Prevention and the importance of self-care

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A Holiday Hodgepodge [Rebroadcast]

Tue, 24 Dec 2024 15:39:49 +0000

When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you!

On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas.

Today on The Lab Report:

5:00 Kentucky Fried Christmas
7:00 The Christmas Pickle
8:55 Pooping logs, yule goats, & frankincense
14:30 Christmas disease game
17:30 Santa Claus towns
20:00 ‘Twas the Night Before Christmas

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Surviving Cold & Flu Season

Wed, 11 Dec 2024 11:00:00 +0000

As the days get shorter and the air turns crisp, cold and flu season sneaks in bringing sniffles, coughing, fatigue, and fever. It’s a time when germs spread easily, and our immune systems face a tough challenge. When you add holiday stress in the mix, it becomes even more important to boost your defenses, and optimize your immunity.

In today’s episode, we offer tips to help you unlock your body’s natural defenses as we try to navigate cold and flu season. This podcast has everything you need to stay ahead of seasonal sickness so you can enjoy your holiday.

Today on The Lab Report:

· 3:00 Yep -Patti is still sick

· 5:05 Vitamin D is awesome

· 8:50 Sleep quantity and quality

· 12:00 Michael’s rant on herbal therapies

· 17:40 The importance of zinc

· 20:05 Cortisol and dampened immunity

· 22:55 Honorable mentions

Additional Resources:

Habitat for Humanity - AVL

Rural Organizing and Resilience

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Surviving Holiday Stress

Wed, 27 Nov 2024 11:00:00 +0000

The holiday season is a time of joy, connection, and celebration – but to be honest, it can also be incredibly stressful. Between hosting dinners, finding the perfect gifts, managing finances, and navigating family dynamics, it’s easy to feel overwhelmed. The good news? You’re not alone and there are ways to reclaim the magic of the season without losing your sanity.

In today’s podcast, we dive into the science of stress and how the vagus nerve holds the key to calm. Discover how breathwork, mindfulness, and gratitude can transform your holiday experience, helping you stay grounded, joyful, and resilient. Tune in and gift yourself some peace this season!

Today on The Lab Report:

· 3:10 Holiday season is here!

· 6:20 Stressors and getting to the root cause of expectations

· 8:40 Sympathetic vs. Parasympathetic – neuroendocrine responses

· 11:30 Vagus nerve

· 13:15 Breathwork techniques, singing, gargling, laughing

· 18:15 Mortality of holiday season

· 20:15 Mindfulness and joy

· 24:00 Gratitude

Additional Resources:

Habitat for Humanity - AVL

Rural Organizing and Resilience

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Weathering the Storm: Community, Mental Health, and the Path to Recovery Post-Hurricane Helene

Mon, 04 Nov 2024 11:00:00 +0000

Where to begin? It’s been a few weeks since you’ve heard from us – thank you so much for your amazing support and patience. As you may know, Hurricane Helene brought devastation to western North Carolina, eastern Tennessee, South Carolina, Georgia, and Florida. Genova Diagnostics is headquartered in the heart of Asheville, North Carolina. With that, it’s been a challenging few weeks. But the heroic efforts of many, and the resilient spirit of our team have us back up and running. Genova continues to support our local community- many of whom are still struggling and have lost everything. #WNCStrong

Today’s episode is a bit different than usual. It’s our story. Our lessons learned. Genova’s story of resilience when faced with a devastating, historic hurricane.

Additional Resources:

Habitat for Humanity - AVL

Rural Organizing and Resilience

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This Podcast Will Give You Heartburn

Tue, 17 Sep 2024 10:00:00 +0000

Gastroesophageal reflux disease (GERD), or heartburn, is incredibly common as is the use of stomach acid suppressing medication. But what if there is far more to the story than stomach acid? There are many other factors to consider in a patient with heartburn. We are going to dive into the physiology of gastric acid, gastric hormonal signaling, and a slew of medications and foods that might be the real culprit. Are PPI’s over prescribed? Are we missing the picture? Tune in to find out.

In today’s episode, we tackle some burning questions about GERD and try to get to the root cause. Are acid suppressing medications always the answer? Perhaps the story is not that simple.

Today on The Lab Report:

3:45 Conventional medicine’s approach to GERD
6:30 The roll of the lower esophageal sphincter (LES)
8:15 Stomach acid and gastric hormonal signaling
13:20 Foods that affect the LES
14:15 PPI’s - controversy and weaning
18:00 Prescriptive meds, lifestyle, and the LES
19:50 Hiatal hernias
21:30 Question of the Day
- How does hypochlorhydria or PPI use affect Genova testing?

Additional Resources:

Genova Connect **PROMO CODE TheLabReport20 for 20% off your purchase**

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What are Nootropics?

Wed, 04 Sep 2024 10:00:00 +0000

Occasionally, there are new and novel things introduced into the functional medicine and biohacker space that catch our attention. Lately, you might have heard a lot of people talking about the amazing health benefits of “nootropics,” but what are they? Coming from the name of the Greek word Nous (meaning “mind”), nootropics are medicines designed to improve cognitive function and protect the brain. Many of us could use a healthy dose of cognitive support to help us through our busy lives, but what is the truth about nootropics and where can we find them?

In today’s episode, we discuss the what, how, and why of nootropics. We explain what things are considered nootropics and how they work in the body. We also discuss what may be unexpected nootropic things you can do everyday that may not even be termed a nootropic. Listen for more information on how you can help get the most out of your cognition.

Today on The Lab Report:

3:30 There’s a lot of buzz about nootropics
4:30 Defining Terms: Nootropics
6:30 Michael rants on what is not a nootropic?
8:30 How do nootropics work in the body?
10:30 Vinpocetine
12:55 Huperzine A and brain energy
15:00 Astaxanthin - not just for flamingos
18:00 Nootropic herbs – aka “adaptogens”
22:10 Ginkgo biloba – a powerful nootropic
24:15 Are there side effects?

Additional Resources:

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Are We Really Talking About Artichokes?

Tue, 27 Aug 2024 10:00:00 +0000

Ok, we know what you’re thinking…. Artichokes? Really? Yes really. It may seem a bit out of left field, but you’d be surprised at the many health benefits from either eating artichokes or taking an extract supplement. As a vegetable, it contains fiber, vitamins, minerals, and antioxidants. Extracts made from artichoke leaves, stems, and roots have been used as nutraceutical agents to support the GI tract, liver, and cardiovascular system. But why?

In this episode, we peel back the layers of the artichoke – a very mysterious plant indeed. Is it possible to boost your health with artichoke leaf extract? Tune in to find out!

Today on The Lab Report:

3:25 Random artichoke topic – functional food
4:30 Jerusalem artichoke globe artichoke
6:00 Fruit, vegetable, and flowers - Extract vs. Whole food
8:15 Gut and liver health
10:35 Milk thistle vs. artichoke
12:30 Artichoke extract is antimicrobial
14:50 Powerful impact in IBD
18:00 Cardiovascular disease, neurodegenerative disease, cancer
20:00 Artichoke Game Time!!

Additional Resources:

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Mast Cell Activation Syndrome & Histamine [Rebroadcast]

Tue, 20 Aug 2024 10:00:00 +0000

Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyperreactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused.

In today’s episode, we focus on the role of mast cells and histamine in the immune response. We discuss the different mast cell activation disorders, how to diagnose them, and what you can do about it.

Today on The Lab Report:

3:05 Mast Cell Activation Diseases
5:15 What is a mast cell? Why do we care?
7:05 Symptoms of histamine release
8:40 Histamine intolerance vs. MCAS
11:11 Foods: High Histamine or Low Histamine?
14:25 Non-food related histamine associations
15:30 Diagnosing and treating MCAS
18:00 Question of the Day
- What Genova profiles can help parse out histamine intolerance v. MCAS?

Additional Resources:

IgE Food Antibodies Profile

IgE Inhalants - Allergy Profile

IgE Mold - Allergy Profile

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Desulfovibrio - Friend or Foe?

Tue, 13 Aug 2024 10:00:00 +0000

The gut microbiome harbors trillions of commensal organisms which play a central role in our health. This community is sometimes referred to as our hidden metabolic organ due to its immense impact. Our diet and lifestyle play an important role in feeding the microbiome and keeping the colonies in balance. Should we be concerned if any one bacterial colony overgrows?

Today we discuss the commensal bacteria Desulfovibrio. Since this genus of bacteria can reduce sulfate and make hydrogen sulfide gas, overgrowth can have clinical implications. Listen in for more information on why you should care and what you can do about it.

Today on The Lab Report:

2:45 Why Desulfovibrio? Define Some Terms!
- Commensalism
5:20 Desulfovibrio – what does it do? Why that name?
7:10 Hydrogen sulfide gas – symptoms and its role
9:00 IBD and Desulfovibrio
10:00 Can you have DV and be healthy?
11:00 Other correlations – neurodegenerative disease, autism, metabolic syndrome, cancer
13:45 Pre- and pro-biotics as treatment adjuncts and the Naturopathic Therapeutic Order
17:09 Fructo-oligosaccharides and prebiotics to feed the microbiome – it depends
19:30 Question of the Day
- Does the GI Effects measure other sulfur-reducing bacteria?
21:15 Evolving research – Desulfovibrio and GLP-1 hormones

Additional Resources:

Genova Connect **PROMO CODE TheLabReport20 for 20% off your purchase**

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What the heck is mTOR?

Tue, 06 Aug 2024 10:00:00 +0000

There are a lot of terms bantered about in the biohacker and longevity space. With that, you’ve likely heard of mTOR – mechanistic (mammalian) target of rapamycin. But what exactly is it? mTOR is a key regulator in your body’s metabolic and growth processes. It integrates various signals, including nutrients and growth factors, to control processes like protein synthesis, autophagy, and lipid metabolism. Because it regulates growth, dysregulation of mTOR has been implicated in various diseases, including cancer.

In today’s episode, we simplify the science behind mTOR – mechanistic target of rapamycin. This crucial enzyme may be the key to unlocking groundbreaking advancements in wellness, anti-aging, disease prevention, and health optimization.

Today on The Lab Report:

3:00 mTOR – Why are we even covering this topic?
4:40 What is it? Muscle growth vs. autophagy
6:25 Why is it called mTOR?
9:00 Highly conserved and in every cell, every organ
10:30 mTORC1 and mTORC2
11:25 Influences and sensors – it’s more than leucine
14:25 Dysregulation of mTOR – does protein cause cancer?
17:30 Should people take rapamycin for longevity?
20:20 Question of the Day
- Where does mTOR work in muscle protein synthesis?

Additional Resources:

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The Multi-Omics Series Part 4: CBS and Transsulfuration [Rebroadcast]

Tue, 30 Jul 2024 10:00:00 +0000

Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.

Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important and what a genetic variant in CBS might mean for you and your patients.

Today on The Lab Report:

2:20 Reminder of what we mean by multi-omics
4:50 Introducing the CBS enzyme and the sink drain metaphor
7:40 The genetics of CBS – the silent mutation – and its potential effects
12:40 Better Know A Biomarker: Cystathionine!
16:20 Activators and inhibitors of CBS and its effects on other biomarkers
18:55 Question of the Day:
- Does a CBS SNP cause elevated ammonia levels?
21:40 Evaluating surrounding biomarkers and how do you treat this SNP?

Additional Resources:

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Disclaimer: The content and information shared in The Lab Report is for educational purposes only and show not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

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Glutathione - Things You Don't Know

Wed, 24 Jul 2024 14:12:08 +0000

Many of us have heard of glutathione and understand that it is a powerful antioxidant – but why? What is it? How does it work? Understanding the mechanisms of this crucial molecule can help you fully grasp its importance. Oxidative stress and the damage of free radicals underlie the aging process and many chronic conditions. There’s no greater tool to combat oxidative stress than glutathione.

In today’s episode, we break down the science of glutathione and redox reactions. You will learn how glutathione works, how to support optimal levels, and how it connects to the methylation cycle!

Today on The Lab Report:

3:00 Is there more to Glutathione than you think?
4:20 Glutathione as a tripeptide
5:40 Redox reactions & the role of glutathione
8:30 Rate-limiting steps – cysteine, NAC
9:55 Holding!! Maybe it’s glycine
12:30 Factors needed for production
13:05 Measuring levels – total, reduced, oxidized
16:40 Clinical associations
18:30 Supplementing to support glutathione
22:00 Question of the Day
- Is glutathione related to methylation?

Additional Resources:

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The Cellular Wellness Solution

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Creatine

Tue, 16 Jul 2024 10:00:00 +0000

Creatine is a powerhouse supplement known for enhancing muscle strength, endurance, and recovery. By boosting ATP production, it fuels muscles during intense workouts, leading to greater gains and faster progress. Beyond its skeletal muscle benefits, creatine supports cognitive function, fertility, sight, hearing, and just about every process in the body.

Today we discuss creatine and its many health benefits. Whether you're an athlete striving for peak performance or someone simply looking to improve overall health and vitality, consider fueling your potential with creatine.

Today on The Lab Report:

3:50 Creatine and methylation
6:00 How does the body make creatine?
7:55 Creatine and skeletal muscle
10:40 Brain health, cognition, sight, and hearing
13:05 Creatine and Fertility
14:15 How much do we make; how much do we need?
17:30 Confusion around kidney function and creatine supplementation
19:15 Side effects and hydration

Additional Resources:

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Herbs for Cellular Health & Longevity with Dr. Bill Rawls

Tue, 09 Jul 2024 10:00:00 +0000

Dr. Bill Rawls was a practicing OB/GYN physician for decades before his health began to suffer and he was faced with the limitations of modern medicine. Embarking on his own health journey, he dove headfirst into holistic and herbal therapies and found ultimate wellness. Dr. Rawls now teaches and writes extensively about the power of herbal medicine. He’s written several books including Suffered Long Enough, Unlocking Lyme, and his latest book The Cellular Wellness Solution. Dr. Rawls even started his own herbal supplement and wellness company called Vital Plan.

In today’s episode, Dr. Bill Rawls discusses his new book, The Cellular Wellness Solution, a fresh take on the critical role our cells play in unlocking wellness and supporting health. He champions the power of herbal medicine and explains why you should too.

Today on The Lab Report:

4:00 Meet Dr. Rawls and hear his journey to herbal medicine
8:45 The Cellular Wellness Solution – 5 underlying cellular stressors
14:05 Microbial stress, chronic disease, and cancer?
21:10 Germ theory vs. Terrain theory
25:50 Difference between pharmaceutical drugs and herbs
32:15 Isolated constituents vs. whole herbs, adaptogens
33:20 Daily-use herbs, adaptogens, antimicrobials, anti-inflammatories
40:40 Current-day farming, primitive foraging, and the effects on our plants
44:30 Vital Plan and cautionary tales regarding supplement quality
50:20 The Fireball

Additional Resources:

Dr. Bill Rawls' website

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Integrative Sports Nutrition with Ian Craig

Tue, 02 Jul 2024 10:00:00 +0000

In the world of athletic performance, there are plenty of health experts. But none like Ian Craig. Ian Craig takes a holistic and very personalized approach. With his joint academic backgrounds in exercise physiology and nutritional therapy, and a long successful career as a British middle-distance runner and coach, he’s been developing the concept of integrative sports nutrition for the past 20 years.

Today we speak with Ian Craig who lays out the case for personalized and holistic care when it comes to optimizing athletic performance. Through his Centre for Integrative Sports Nutrition in Scotland, he’s been a leading voice worldwide bridging the gap between conventional sports nutrition and a functional approach to health.

Today on The Lab Report:

5:00 Meet the amazing Ian Craig
6:55 Balancing life load and athletics
11:10 Runners vs. other athletes
14:30 Integrative Sports Nutrition Pyramid
21:00 Convincing athletes to rest!
24:35 Ergogenic aids
28:05 The line between ergogenic aids and PEDs
30:25 Trade-offs with ergogenic aids
32:45 Upcoming textbook and CISN training
37:15 The Fireball

Additional Resources:

Centre for Integrative Sports Nutrition (CISN)

Health Feeds Performance Podcast

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Patti & Michael Discuss AI in Healthcare

Tue, 25 Jun 2024 10:00:00 +0000

Artificial intelligence and machine learning is being leveraged in every facet of society to improve efficiency and drive innovation. Healthcare is no different. Language models, algorithms, machine learning, and more are being developed and used to help with education, behavior change, administrative tasks, predictive risk assessments, and at times, disease diagnosis.

In today’s episode, we discuss areas where the healthcare industry is harnessing artificial intelligence. With such powerful technology at our fingertips, it is always important to take a pause to debate the exciting capabilities but also its limitations and biases.

Today on The Lab Report:

5:25 Artificial intelligence is everywhere
8:36 Patient education, oversight, and bias
9:50 Benefit in preventing human error
10:40 Diagnostic models and risk assessments
12:20 Bias and mistakes on both sides – where’s the liability?
16:10 Patient confidentiality concerns
17:30 Wearable devices and behavioral change
21:00 Personalization, empathy, and the human element
23:00 Generative AI, novel insights, and sound data
24:55 Considering all traditions of medicine

Additional Resources:

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Auto-Brewery Syndrome

Tue, 18 Jun 2024 10:00:00 +0000

Is it possible to be drunk without drinking alcohol? Actually, yes. There is a condition called auto-brewery syndrome whereby an imbalance in your gut microbiome can ferment carbohydrates to create alcohol. Blood alcohol levels can get surprisingly high. Though this condition is thought to be rare, it might just be underdiagnosed. Patients are dealing with legal ramifications, social stigmas, and disbelief by friends, family, and physicians.

Today we introduce the topic of auto-brewery syndrome to raise awareness that your gut microbiome can produce alcohol. We discuss how it occurs, how to diagnose it, and some strategies to treat it.

Today on The Lab Report:

3:10 What is auto-brewery syndrome?
5:30 Causes and clinical associations
9:45 SIBO/SIFO – should we be checking alcohol levels?
10:50 Chronic tolerance and long-term alcohol effects
12:20 How to diagnose ABS
14:30 Treatment strategies
17:00 Is it as rare as we think? Is there a spectrum?
18:12 Question of the Day
- What patterns might we see on GI Effects and NutrEval?

Additional Resources:

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Auto-Brewery Syndrome Advocacy and Research

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Food Additives - Hidden in Plain Sight

Tue, 11 Jun 2024 10:00:00 +0000

Food labels can be very confusing. In fact, many of us completely ignore them. If you look at the ingredients in many processed foods, you’ve probably tried to pronounce some of the chemical compounds listed in the ingredients. The food industry adds chemicals to food to either enhance flavor and color, or to preserve shelf life. There are thousands of accepted food additives and some may have important health implications.

In today’s episode, we discuss just a few additives you might want to keep an eye out for next time you go to the grocery store.

Today on The Lab Report:

3:20 MSG – monosodium glutamate
6:40 Nitrites and nitrates
9:55 The “Name that Food” game
12:45 Sulfites are everywhere
13:55 Maraschino cherries are polarizing?
15:20 Sulfites as a top food allergen
16:55 Food colorings, FD&C, lakes, and blue rats
21:25 Artificial vs. natural flavoring

Additional Resources:

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Basil Seeds: The New Superfood with Shakira Niazi

Tue, 04 Jun 2024 11:52:06 +0000

Shakira Niazi is the founder of Basil Seed Works – an organic basil seed product line featuring the superfood ZenBasil. As a refugee from war-torn Afghanistan who was later raised and educated in the US, Shakira’s path to becoming an entrepreneur is remarkable. Although she’s known for her work with Vita Water – helping to solve the world water crisis and providing water points to poor villages around the world, her current focus is to bring basil seeds from the Far East to the Western world. Basil seeds are a natural source of fiber, omega-3 fatty acids, vitamins, minerals, and antioxidants.

In today’s show, Shakira Niazi tells us her inspiring story - from childhood refugee to being featured in Times Square. We also discuss the amazing health benefits of basil seeds and why they are the new superfood!

Today on The Lab Report:

5:30 Meet Shakira Niazi and hear her amazing story
10:30 Changing courses through the pandemic
20:40 Health benefits of basil seeds
26:40 Hydrating and using basil seeds
28:45 ZenBasil vs. other basil seeds
30:45 Where to find ZenBasil
32:00 The Fireball

Additional Resources:

ZenBasil

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Dr Stephanie Venn-Watson: Cellular Health with Fatty15

Tue, 28 May 2024 10:00:00 +0000

Dr. Stephanie Venn-Watson dedicated her life to public health and veterinary epidemiology. In studying dolphins, she discovered the first essential fatty acid to be found in over 90 years – C15:0 (pentadecanoic acid). Dr. Stephanie’s discovery and further research on C15:0 has uncovered some amazing cellular health benefits and significant potential for disease prevention. With this knowledge, Dr. Stephanie pivoted and founded fatty15 - a company that produces the world’s first, and only science-backed, patented C15:0 supplement.

In today’s episode, we speak with Dr. Stephanie Venn-Watson about her latest research into the newly discovered essential fatty acid C15:0 and how supplementation with fatty15 could be a game-changer for cellular health.

Today on The Lab Report:

4:45 Stephanie Venn-Watson on veterinary epidemiology and dolphins
10:15 Pentadecanoic acid (C15:0), dolphins, and disease
12:20 Food sources for C15:0
15:35 Essential fatty acid criteria
18:45 Cellular stability and pentadecanoic acid
21:10 Red blood cell membranes and testing
24:10 Iron and ferroptosis
28:00 Measuring cell fragility
31:30 Ferroptosis and inflammatory cascades
34:05 Fatty15 supplementation
39:10 The Fireball

Additional Resources:

fatty15

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The Methylation Cycle: Deep Cuts

Tue, 21 May 2024 10:19:44 +0000

Methylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In a previous episode, we introduced the topic of methylation and the basics of this biochemical reaction. However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance.

Today, we dive a bit deeper into the biochemistry of methylation and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Genova’s Methylation Pathway Handout to follow along.

Today on The Lab Report:

2:50 Quick review of the methylation cycle
4:45 The important relationship between choline and betaine
7:05 Logical Speculation: Why is the betaine: choline ratio associated with disease risk?
9:35 Dimethylglycine (DMG)
11:15 Sarcosine and the ‘SAM disposal chute’
14:20 Glycine: What does it do?
16:55 Transsulfuration and glutathione
21:00 The multi-omics of the methylation panel
22:25 Question of the Day: What is the stability of measuring SAM and SAH?

Additional Resources:

Get your copy of Good Energy today!

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Metabolic Health = GOOD ENERGY with Dr. Casey Means

Tue, 14 May 2024 10:00:00 +0000

We are honored to welcome Dr. Casey Means back to the show. She is not only a passionate advocate for metabolic health, but also a voice of reason amidst a broken healthcare system, a profound champion spreading the message of connectedness and fearlessness, and lastly a dear friend. Dr. Means’ new book “Good Energy – The Surprising Connection Between Metabolism and Limitless Health” is available now anywhere books are sold.

In this episode, we talk to Dr. Casey Means about her new book “Good Energy” which outlines how to connect the dots in healthcare, the critical importance of metabolic health, and practical tips to change your life and create your own GOOD ENERGY.

Today on The Lab Report:

3:10 The Amazing Dr. Casey Means on connection vs. siloes in medicine
8:45 Economics of the current healthcare model and outdated thinking
12:15 Longevity and biohacking – where have we lost our way?
19:55 Fear of death, control, and transcending the fear mindset
23:20 Fixing incentive structures of the healthcare system & food and farm industries
33:10 Practical tips and eating for GOOD ENERGY
40:55 Overcoming behavior change obstacles – listen to your body!
44:00 ROI in eating healthy whole foods
45:35 Life is miraculous, live in awe- not fear
48:05 The Fireball

Additional Resources:

Casey’s Newsletter sign-up: https://www.caseymeans.com/newsletter

Casey’s Social Media Platforms:

Instagram: https://www.instagram.com/drcaseyskitchen/

Twitter: https://twitter.com/CaseyMeansMD

TikTok: https://www.tiktok.com/@caseymeansmd

YouTube: https://www.youtube.com/@CaseyMeansMD

LinkedIn: https://www.linkedin.com/in/casey-means-md/

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The Methylation Episode!

Tue, 07 May 2024 10:00:00 +0000

The word ‘methylation’ has become somewhat of a buzz word in functional and personalized medicine. We’ve mentioned it several times throughout many episodes of The Lab Report – hard to avoid since it’s involved in just about every biological process.

In today’s episode, we finally hit the topic of methylation head on and dive into the methylation cycle itself. What is it? Why should you care? Although biochemistry can be intimidating, listen as we simplify and demystify the steps involved. You may find it helpful to refer to a Methylation Pathway Chart while listening to this one!

Today on The Lab Report:

2:00 What is methylation and why is it clinically important
5:30 Jumping into the biochemistry – metaphors to the rescue!
11:35 Homocysteine
14:00 The main pathway versus back up pathway
19:33 Transsulfuration
22:30 Multi-omics and the methylation cycle
27:50 Question of the Day
- “What does it mean if homocysteine is low?”

Additional Resources:

Everest Functional Psychiatry and Wellness

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Holistic Mental Health with Everest Goldstein

Tue, 23 Apr 2024 10:00:00 +0000

Everest Goldstein is a board-certified Psychiatric Nurse Practitioner who is also certified in Functional Medicine and has an extensive background in integrative wellness interventions. She deeply cares about her patients and devotes her time to working closely with each of them to address their individual needs. Knowing the importance of the brain-body connection, Everest addresses the body as a whole to optimize health and wellness.

In today’s episode, we dive into the root causes of mood disorders and psychiatric illness with Everest Goldstein. Everest discusses how nutrition, diet, and lifestyle can contribute to mental health and wellness. If you are struggling mentally, emotionally, or physically, Everest is here to help you regain your life.

Today on The Lab Report:

4:30 Meet Everest Goldstein and hear about her passion for psychiatry
7:45 Everest’s unique approach to mental health
9:55 The debate of mental health root causes
12:15 Gut microbiome and the brain connection
16:50 Nutrition changes for better outcomes
20:00 Using the ketogenic diet in mental illness
23:50 Protein, amino acids, and neurotransmitters
26:00 The role for psychiatric medications
28:30 Coaching lifestyle changes and motivation
31:50 Therapy and counseling
35:12 The Fireball

Additional Resources:

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The Benefits of Berberine

Tue, 09 Apr 2024 10:00:00 +0000

Berberine is an alkaloid compound that can be extracted from several plants. It is a widely used supplement in personalized medicine and is also beginning to get some traction within the conventional medicine space. Berberine is mainly used in the GI tract for its antimicrobial effects, but as it relates to gut health, that’s just the tip of the iceberg. What is even more fascinating is berberine’s vast systemic metabolic influences.

In today’s episode, we dive into the wide array of berberine’s important effects. Not only on the gut, but also on detoxification systems, skin, eyes, lipid and blood glucose control, hypertension, and cardiovascular health.

Today on The Lab Report:

4:00 Berberine – not an herb – where does it come from?
6:55 Overall gut modulator, skin health, and detox
13:05 Metabolic dysfunction – blood glucose, protein, lipids
14:50 Cardiovascular effects and heart health
16:00 Contraindications and safety considerations
18:00 What’s in a name?

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Healthy Gut, Healthy Skin with Dr. Nigma Talib

Tue, 02 Apr 2024 10:00:00 +0000

For decades Dr. Nigma Talib has been helping patients using her clinical expertise in naturopathic medicine. Her contributions to the field are recognized globally. Dr. Nigma has authored best-selling books such as “Reverse the Signs of Ageing” and “Younger Skin Starts in the Gut.” She was one of the first pioneers to introduce vitamin supplements in the fashion industry and she’s responsible for the radiant, glowing skin of some of Hollywood’s most famous faces.

In today’s episode, we are honored to meet Dr. Nigma Talib. We discuss her holistic approach to health and learn her skincare tips and tricks to reverse the signs of ageing.

Today on The Lab Report:

3:50 Meet Dr. Nigma Talib
9:40 The importance of gut health in aging
12:40 Nutrition and skin
15:20 Dr. Nigma’s skincare products
16:55 Hydration
18:15 Light and radio frequency
20:00 Vampire facials and PRP
25:30 The Fireball

Additional Resources:

Dr. Nigma's website

Shop Dr. Nigma's products

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A Thyroid Masterclass with Taylor Morgan Christie, PA-C

Tue, 26 Mar 2024 10:00:00 +0000

Taylor Morgan Christie is a board-certified Physician Assistant, a registered dietitian nutritionist, and she’s double board certified in functional medicine through IFM and IFNA. So, it should come to no surprise that she can basically riff on any topic we throw at her. However, she has a special passion for treating thyroid disorders and helping her patients find whole wellness. She’s spent over a decade studying and mastering her clinical approach and today we learn all about it.

On today’s episode, we talk all things thyroid with Taylor Morgan Christie, PA-C. Thyroid physiology, symptoms, medications, supplements, nutrition, labs, and more! Truly a masterclass for anyone suffering from thyroid disorders or clinicians not sure where to start.

Today on The Lab Report:

5:00 Meet Taylor Morgan Christie and hear about her journey
10:35 Recognizing thyroid symptoms
12:20 Thyroid testing 101 - “normal” vs. optimal and timing med dosing
18:35 Choosing thyroid medications
23:04 Reverse T3 interventions
24:50 Proper absorption of thyroid medications
26:30 Nutrition and the thyroid
29:30 After optimizing - when to re-test labs?
34:05 The Fireball

Additional Resources:

MyWholeWellness.com

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Dr. Anna Lembke - The Dopamine Hit and Addiction [Rebroadcast]

Tue, 19 Mar 2024 10:00:00 +0000

If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry?

In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways.

Today on The Lab Report:

3:00 Anna Lembke explains dopamine and the reward system
6:05 Dopamine hits in today’s society
10:40 Moderation vs. Abstinence
13:30 Social media and children
15:00 Does society award addictive behavior?
18:45 Long term dopamine dysfunction and Parkinson’s disease
22:00 Parenting in the digital age
27:20 The Fireball

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect.

See omnystudio.com/listener for privacy information.

Boron!...actually never mind, not boron.

Tue, 12 Mar 2024 10:00:00 +0000

Ok, well…. Today’s episode is a bit unique…. The intention was to discuss the important benefits of a trace mineral called boron. It is an important mineral, make no mistake. But, as we started recording, we got bored. Turns out talking about boron is kind of boring! So, we do hit the boron highlights, but then, in typical Patti & Michael fashion, we veer off into debate and discussion. The topic became the danger of misinformation by health influencers and how to remain skeptical.

Today on The Lab Report:

3:10 Thirty seconds on boron
4:35 A dose of skepticism toward health influencers
7:55 Health information changing tides
11:20 Methylation SNPs and reductionism
15:30 GLP-1 agonists and total body systems
21:30 Wrap up – always be curious and skeptical

Additional Resources:

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The Power of Custom Formulas with Dr. Lydia Thurton

Tue, 05 Mar 2024 11:00:00 +0000

Genova’s nutritional testing offers precision results and personalized recommendations to create a nutritional treatment plan for optimal health and wellness. But for patients and clinicians, this can seem overwhelming when there is a significant amount of nutritional need. In addition to dietary counseling, clinicians often reach for supplements. VitaminLab is a premier supplement company in Canada that can customize results from the NutrEval and Metabolomix+ into as few pills as possible to help with patient compliance. Dr. Lydia Thurton is a naturopathic physician who works with clinicians through VitaminLab to help them through the process.

In today’s episode, we talk to Dr. Lydia Thurton and discuss the process of customizing nutritional formulas, cautionary tales you should be aware of when choosing a supplement company, and the quality controls used by VitaminLab.

Today on The Lab Report:

4:25 Meet Dr. Lydia Thurton and hear about her path to the supplement industry
7:30 Combining supplements into as few pills as possible
9:40 Pill fatigue and compliance
11:00 Line between optimizing diet vs. supplementation
13:00 Choosing where to get your supplements – VitaminLab quality controls
17:35 Lydia’s private practice – passion for women of color
20:10 Online Mental Health Facebook group
22:10 Where to connect with VitaminLab and Dr. Lydia
23:15 The Fireball

Additional Resources:

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Dr. Lydia's Thai Inspired Chicken Meatball Soup

VitaminLab

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Hot Takes: The Cayenne Podcast

Wed, 28 Feb 2024 11:00:00 +0000

Cayenne pepper, derived from the Capsicum annuum plant, is a fiery herb renowned for its intense heat and vibrant flavor. It contains a compound called capsaicin which is not only responsible for its spicy punch, but also numerous health benefits. Beyond its culinary uses, cayenne is highly regarded for its medicinal properties in gut health, pain relief, and even cardiometabolic disease.

In today’s episode, we turn up the heat as we delve into the fiery world of cayenne. From its origins to its culinary and medicinal uses, we’ll uncover the secrets and surprising health benefits of this spicy superstar.

Today on The Lab Report:

3:20 Why are we talking about cayenne?
4:40 Ethnobotany of cayenne
8:30 Capsaicin, the heat, and substance P
9:50 Cayenne and metabolic syndrome
11:40 GI tract effects – how counterintuitive!
15:30 Cardiovascular disease and cayenne
16:40 Headaches and pain, topical cayenne – intranasal cayenne? WHAT!
18:55 Wilbur Scoville rabbit hole re: Scoville Units
22:50 What’s in a Name?????

Additional Resources:

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What We Don't Know About Hormones - Part 3

Tue, 20 Feb 2024 11:00:00 +0000

Genova’s Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine.

Today is part 3 of our series where we challenge common doctrine in hormone testing. It’s good to be humble, take a fresh look at dogmatic concepts, and rethink what we thought we knew.

Today on The Lab Report:

4:35 Endo+ - we are learning new lessons
6:05 Salivary testosterone in females
8:10 Urinary cortisol and the effects of dietary sodium
10:50 Steroidogenic pathway and aromatase enzymes
12:15 Ben Bikman, insulin resistance, and aromatase
13:50 Salivary collection – passive drool vs. devices
16:20 Serum hormone levels and BHRT
18:25 Salivary progesterone and stress
20:20 Estriol and estrogen metabolism

Additional Resources:

Endo+

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Red Meat & Heart Disease [Rebroadcast]

Tue, 13 Feb 2024 11:00:00 +0000

Foods come in and out of favor all the time. Eggs are good for you… no wait, they are bad… nope, good again – let’s not even discuss butter! There are many disease correlations related to specific foods and literature continues to evolve. One such focus is on red meat and its correlation to cardiovascular disease. But why? Is all red meat bad? Can you eat red meat and not increase heart disease risk? What about it should cause concern? Interestingly, the answer lies in the microbiome’s ability to metabolize the carnitine in red meat into a metabolite called trimethylamine (TMA). What happens from there is the key! But be warned, there is more to TMA than red meat and carnitine.

Today we discuss TMA and how it becomes a cardiovascular risk factor (TMAO). We tell you about TMA’s many sources - besides red meat - and why you should care.

Today on The Lab Report:

2:10 Food controversies
3:50 Break it Down: Trimethylamine (TMA) and trimethylamine N-oxide (TMAO)
6:40 TMAO, carnitine, and choline
10:00 Wait, which foods are actually the problem?
13:50 Red meat, TMAO, and cardiovascular risk
18:40 Dietary microbiome changes
20:05 Question of the Day:
- Which Genova profiles can help?

Additional Resources:

Metabolic Health Summit 2024

Cardio Check

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Patti & Michael On The Road at Metabolic Health Summit

Tue, 06 Feb 2024 11:00:00 +0000

Patti & Michael are on the road! We recorded this unique episode from the Genova Diagnostics booth as a sponsor of the Metabolic Health Summit 2024 in Clearwater Beach, Florida. This conference brings together cutting-edge research, world-class speakers, and the leading experts in metabolic health. As you can imagine, Genova’s testing is a key element in getting to the root cause of metabolic disfunction and optimal health. The personalization of our testing and results can help guide therapeutic modalities that may not be so obvious.

In today’s episode, you’ll hear Patti & Michael recorded live from the Genova booth at Metabolic Health Summit 2024. We recap some of the incredible clinical insights we gained from attending the lectures. We also chat live with some of our friends, old and new, to keep you up to date with the latest innovations in the metabolic health industry.

Today on The Lab Report:

4:00 - Where are we? And, what is Metabolic Health Summit?
4:50 - Dr. Ben Bikman's Research on Adipose Tissue
6:45 - Pearls from Dr. Andy Galpin's Lecture
10:10 - Metabolic Psychiatry
13:00 - Using Specialty Testing for Metabolic Health
16:15 - Dr. Sheila Dean Stops By
17:15 - Dorian Greenow - Co-Founder of Keto-Mojo
24:15 - QOTD - Can you be metabolically health if you aren't on the ketogenic diet?

Additional Resources:

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Herbs for Cellular Health & Longevity with Dr. Bill Rawls

Tue, 30 Jan 2024 11:00:00 +0000

Today on The Lab Report:

4:00 Meet Dr. Rawls and hear his journey to herbal medicine
8:45 The Cellular Wellness Solution – 5 underlying cellular stressors
14:05 Microbial stress, chronic disease, and cancer?
21:10 Germ theory vs. Terrain theory
25:50 Difference between pharmaceutical drugs and herbs
32:15 Isolated constituents vs. whole herbs, adaptogens
33:20 Daily-use herbs, adaptogens, antimicrobials, anti-inflammatories
40:40 Current-day farming, primitive foraging, and the effects on our plants
44:30 Vital Plan and cautionary tales regarding supplement quality
50:20 The Fireball

Additional Resources:

Dr. Bill Rawls' website

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The Cellular Wellness Solution

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The Hormone Shift with Dr. Taz Bhatia

Tue, 23 Jan 2024 11:00:00 +0000

Dr. Taz Bhatia is a conventionally trained physician who has always been way ahead of her time. For years she’s been combining the best of modern science with eastern medical wisdom to help patients get to the root cause of chronic disease. As one of the OGs in functional and integrative medicine, Dr. Taz has become a national social media influencer, author, speaker, podcaster, television star, and go-to expert in women’s health. Her latest book “The Hormone Shift” offers patients the tools they need to navigate life’s hormone changes with ease.

In today’s episode, we meet the one and only Dr. Taz Bhatia - a world-renowned expert in women’s health. Listen in as we discuss her brand-new book “The Hormone Shift.”

Today on The Lab Report:

4:20 Meet the one and only Dr. Taz!
8:15 Eastern medicine influences
11:45 Advice for clinicians wanting to make the leap!
18:05 Women’s health and Power Types
22:25 The Hormone Shift and approaching hormonal imbalance
25:40 Diet and Lifestyle factors
29:25 Behavior change and the art of medicine
31:50 Taz on social media and YouTube
33:40 The Fireball

Additional Resources:

doctortaz.com

The Hormone Shift

Instagram: @drtazmd

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Endo+

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What We Don't Know About Hormones - Part 2

Tue, 16 Jan 2024 11:00:00 +0000

Genova’s new Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine.

Today is part 2 of our series where we challenge common doctrine in hormone testing. It’s good to be humble, take a fresh look at dogmatic concepts, and rethink what we thought we knew.

Today on The Lab Report:

3:40 Reference ranges – population vs. healthy cohort
8:15 Reference ranges - comparing HRT dosages vs. actual symptoms
10:10 Making sense of urine hormone testing
12:50 Circulating hormone levels vs. tissue effects
18:15 Sex hormone binding globulin vs. free testosterone
20:15 Question of the Day
- What are the logistics of customizing the Endo+?

Additional Resources:

Endo+

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What We Don't Know About Hormones

Tue, 09 Jan 2024 11:00:00 +0000

Hormones are complicated! The body makes dozens of hormones that influence each other. Fine-tuning that full hormonal symphony can lead to significant symptom improvement and well-being. Genova’s testing can help and the new Endo+ Profile is a great place to start. With this latest product upgrade, we’ve spent almost 2 years scouring the literature for the most up-to-date clinical information to help guide clinicians. However, while we were knee-deep in research and literature, we found ourselves with conflicting messaging and realized the echo chamber in personalized medicine might need to be re-examined.

In today’s episode, we begin to challenge a few concepts in hormonal testing. Sometimes it’s good to be humble, take a fresh look at dogmatic concepts, and rethink what we thought we knew.

Today on The Lab Report:

3:50 Endo+ Support Guide and literature diving
6:10 Salivary hormones – Why? How? What does it mean?
9:55 Super-secretors
12:45 Topical hormone replacement therapy and saliva
15:30 Bound vs. unbound, bioavailable vs. inert hormones
18:00 Megalin proteins and androgens
20:30 Free testosterone and the Free Hormone Hypothesis
22:00 Dear Sir……. What is Prestidigitation?

Additional Resources:

Endo+ Profile

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Helping Men Ditch the Dad-Bod with Ali Gilbert

Wed, 03 Jan 2024 11:00:00 +0000

The subject of men’s health is often not discussed. A lot of men don’t proactively seek help for health concerns nor even want to admit there’s a problem. Well, today we’re going to change that. Ali Gilbert is a nationally recognized coach, lecturer, personal trainer, and expert in men’s health. Her Silverback Coaching programs help men from all walks of life, from CEOs to professional athletes and regular dads get to optimal physical and mental health.

Today we meet Ali Gilbert and hear about her passion to help men get jacked, look great naked, optimize testosterone, and conquer nutrition.

Today on The Lab Report:

5:05 Meet Ali Gilbert – convincing men she knows what she’s talking about!
9:15 Difference between coaching men and coaching women
11:40 Current state of men’s health
14:20 Addressing the mental and emotional needs of men
16:20 Athletes vs. non-athletes
19:30 Low testosterone symptoms
21:15 Testosterone replacement therapy
23:35 Natural ways to boost testosterone
26:20 Flipping the mindset switch
28:20 Nutrition – macronutrients and diet camps
33:25 Convincing men to ditch the dad-bod
37:25 What depletes testosterone?
38:04 How to work with Ali Gilbert
39:15 The Fireball

Additional Resources:

Ali-Gilbert.com

Ali's Instagram @thealigilbert

Genova Connect

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A Holiday Hodgepodge [Rebroadcast]

Tue, 19 Dec 2023 11:00:00 +0000

Today on The Lab Report:

5:00 Kentucky Fried Christmas
7:00 The Christmas Pickle
8:55 Pooping logs, yule goats, & frankincense
14:30 Christmas disease game
17:30 Santa Claus towns
20:00 ‘Twas the Night Before Christmas

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Endo+ : The Next Generation of Hormone Assessment

Tue, 12 Dec 2023 11:00:00 +0000

The body makes dozens of hormones that affect our health every day -sex hormones, thyroid, cortisol/stress hormones, melatonin etc. When hormones are out of balance, it can lead to symptoms like hot flashes, low libido, weight fluctuations, hair or skin changes, and many more. These symptoms can overlap since all hormones influence each other. That means, to get a full picture of hormonal health we need a broader lens.

Listen in today as we discuss Genova’s Endo+ Profile – The first of its kind. Endo+ is a modular panel of testing that offers the unique ability to assess saliva, blood, and urine simultaneously. This flexibility allows providers to create their own profiles to reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism – and Genova synthesizes all of that information for you!

Today on The Lab Report:

2:20 Hormones are complicated and interconnected
5:25 The hormone pyramid
8:35 Endo+ Profile – the complete picture
10:50 Break it Down - saliva, blood, urine
13:20 Variables in choosing sample types
18:00 Endo+ Testing options and information synthesis
20:20 Anabolic/Catabolic balance
21:10 Estrogen Metabolism
22:15 Add-ons
23:05 Endo+ puts it all together

Additional Resources:

Endo+ Profile

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Navy SEAL Wisdom & Leadership with William Branum

Tue, 05 Dec 2023 11:00:00 +0000

William Branum is a decorated Navy SEAL veteran with 26 years of active-duty service. Since leaving the military, William has dedicated his life to helping others through mentorship, coaching, speaking, and entrepreneurship. William’s expertise has been sought after by organizations ranging from small universities to Fortune 500 companies. He draws on his experiences to provide practical advice on how to cultivate a leadership style that inspires and motivates others, and how to develop the resilience needed to succeed in challenging environments. William founded the company ‘Naked Warrior Recovery’ to develop premium CBD products to support mental and physical recovery, through which he also supports several philanthropic causes for military and veterans’ mental health.

On today’s episode, William Branum explains how the wisdom and life lessons he gained from his Navy SEAL training can apply to each of us in our life transitions, workplace environments, and personal interactions. William also talks about his CBD products and promoting mental health.

Today on The Lab Report:

3:45 Meet the amazing William Branum and hear about his transition to civilian life
17:40 What is a Naked Warrior?
20:50 N.A.K.E.D., ego, and vulnerability
24:05 CBD products and Naked Warrior Recovery quality assurance
27:30 Cannabinoids, veterans’ mental health, and 22 to Zero
34:35 5 SEALS secrets to success and life lessons
39:30 Leadership and being the CEO of your life
51:00 The Fireball

Additional Resources:

Free e-book "5 SEAL Secrets"

Naked Warrior Recovery

Naked Warrior Apparel

@william.r.branum Instagram

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All Things Magnesium with Dr. Robert Fredrickson

Tue, 28 Nov 2023 11:00:00 +0000

Magnesium is a mineral that is crucially important to hundreds of biochemical reactions in our body. With gradual changes in soil, food processing, and the Standard American Diet, many of us just are not getting enough. So, what do we do? Dr. Robert Fredrickson has recently released a book all about this issue: Magnesium Answers: Unlocking the Secrets of Magnesium. As a functional medicine practitioner, he spent his career educating patients and doctors, but he also has a background as a product educator for major supplement companies. With that, Dr. Fredrickson is in a unique position to help us cut through the noise and understand the power of magnesium.

On today’s episode, Dr. Robert Fredrickson talks about all things magnesium – what it does, why we should care, how much do we need, and how do we choose among all of the different forms of magnesium supplementation?

Today on The Lab Report:

4:50 Meet Dr. Robert Fredrickson
9:30 How do we know if we’re not getting enough magnesium?
12:30 Magnesium in food and bioavailability
16:55 How much mag should we be getting?
18:15 Repleting mag and bowel tolerance
19:30 Measuring magnesium
22:10 Topical vs. IV vs. oral supplements
23:45 Types of magnesium supplementation
31:10 Magnesium toxicity, GI symptoms, Mag v. Calcium, IV mag
36:55 Fiber and magnesium connection
38:55 The Fireball

Additional Resources:

Fredrickson Health Solutions

Magnesium Answers: Unlocking the Secrets of Magnesium

Fredrickson Health Show Podcast

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The Thanksgiving Episode - Encore Presentation

Tue, 21 Nov 2023 11:00:00 +0000

Thanksgiving is a time to be mindful and reflect on our many blessings. During the holiday, many of us enjoy dinner with family and friends without stopping to consider the nutritional aspects of traditional dishes. Today, we discuss the important biochemical and nutritional benefits of Thanksgiving dinner items. We also talk about dealing with the stress of the holidays and the many reasons we are grateful.

Today on The Lab Report:

3:30 Turkey and tryptophan – is it a thing?
5:15 Cranberry sauce apologetics
7:45 Potatoes! - and the microbiome
10:35 Green bean casserole, (fake) mushrooms, and onions
13:15 Hollandaise sauce? Gravy? Stuffing? Ummm…moving on
14:10 Pumpkin is a fruit
15:20 Moderation and modifying your dinner
16:15 Movement and mindfulness
19:20 Gratitude and community – Patti & Michael give thanks

Additional Resources:

Michael's Famous Green Bean Casserole?

https://connect.gdx.net/

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Inflammation Signals - Patti & Michael Vamp on PAMPs, DAMPs, & LAMPs

Tue, 14 Nov 2023 11:00:00 +0000

The immune system works tirelessly to maintain health and well-being. This formidable defense mechanism is comprised of a vast array of cells, tissues, proteins, and molecules that work together to identify and neutralize foreign invaders. The inflammation that ensues can be recognized by redness, pain, swelling, and heat. In order for this process to take place, the body needs to be able to identify what is ‘friend or foe’. But how? There are certain molecular patterns that our immune system recognizes as part of this surveillance and recognition. Some patterns are associated with pathogens - “pathogen-associated molecular patterns” (PAMPs). Others are associated with damaged cells (DAMPs) or lifestyle choices (LAMPs).

In today’s episode, we do a quick refresher on adaptive and innate immunity. We also discuss some signaling molecules that trigger the inflammatory cascade – PAMPs, DAMPs, and LAMPs.

Today on The Lab Report:

3:40 Break it down – innate vs. adaptive immunity
6:40 Pathogen-associated molecular patterns (PAMPs), Pattern Recognition Receptors (PRRs)
10:25 Sterile inflammation: damage-associated molecular patterns (DAMPs)
14:30 Lifestyle-associated molecular patterns (LAMPs) & chronic inflammation
18:25 Question of the Day
- How do we turn off the LAMPs?

Additional Resources:

Genova Connect *PROMO CODE TheLabReport20 for 20% off*

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Brendan Vermeire- Leading the Mental Health Revolution

Tue, 07 Nov 2023 11:00:00 +0000

When it comes to changing the way the world views mental health, one voice remains consistent, science-based, empathetic, and passionate. That’s Brendan Vermeire. Brendan is dedicated to advancing the science of mental health dysfunction through his research, teaching, writing, and speaking. Here in functional and precision medicine, we are always looking for the root cause of any dysfunction. However, Brendan reminds us that mental health can have several root causes that need to be addressed and many of us are falling short when it comes to treating patients with mental illness.

In today’s episode, we meet the amazing Brendan Vermeire. He talks about his passion for changing the way the world views mental health as we dive into some less obvious contributors and root causes. Brendan offers his approach to optimal mental well-being: metabolism, mindset, and the microbiome.

Today on The Lab Report:

4:20 Meet Brendan Vermeire and hear why he’s so passionate about mental health
9:20 Connection between physiology and mindset
11:10 Gut-brain axis and the role of the microbiome
13:45 Go-to practical tips for optimizing the gut for mental health
17:00 Let’s talk about Methylation!
22:35 The exposome and toxins in mood disorders
27:00 Exercise, movement, and motivation
34:00 Meaning, purpose, and ‘the why’
36:40 MetabolicSolutionsLLC.com
37:50 The Fireball

Additional Resources:

Metabolic Solutions

Brendan's Instagram - @the_holistic_savage

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Nonpathogenic Parasites? [Rebroadcast]

Tue, 31 Oct 2023 10:00:00 +0000

The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse’ of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic.

In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don’t need to be treated.

Today on The Lab Report:

3:50 Prevalence and transmission of parasites
6:45 What is a parasite? Are there nonpathogenic parasites?
8:10 3 main classes of parasites
10:20 Detecting parasites in the stool
13:10 Nonpathogenic parasites
- Chilomastix mesnili, Endolimax nana, Entamoeba coli, Entamoeba dispar, Entamoeba hartmanni, Entamoeba polecki, Iodamoeba buetschlii

16:50 Potentially pathogenic parasites
19:25 Question of the Day
- Why doesn’t Genova offer sensitivities for parasites on the GI Effects?

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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The Best Ways to Test the Microbiome

Tue, 24 Oct 2023 10:00:00 +0000

When it comes to assessing the microbiome, technology continuously evolves. With that, our understanding of the microbiome deepens. There is a lot of confusion out there regarding technology. Companies use marketing spin to lead you to believe the newest is the best when in fact, every technology has its strengths and weaknesses. No one method can capture the entire dynamic of the microbiome. Here at Genova, we use many methods to give you the most complete look at overall gut health.

Today we simplify the science behind laboratory assays used to study the microbiome – culture, qPCR, metagenomics, and transcriptomics. Every method has its advantages and disadvantages. We’re cutting through the confusion with no marketing spin, just the facts.

Today on The Lab Report:

3:30 So much confusion around laboratory methods - why should we care?
7:45 Culture technology is old but still so important
11:10 Conventional PCR and qPCR (aka Real-Time PCR)
15:40 Beware of these qPCR shortcomings
19:50 Next-Gen Sequencing
21:40 Metagenomics – not all labs are created equally!!
26:55 The vital role of taxonomy libraries
30:30 Transcriptomics and assessing RNA

Additional Resources:

GI Effects

Hilts Direct Primary Care

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Dr. Michael Hilts on the Direct Primary Care Model

Tue, 17 Oct 2023 10:00:00 +0000

Many clinicians learn about functional medicine and get very excited to start but just can’t figure out how to fit it into their practice or make the big leap away from conventional, insurance-based practice models. Dr. Michael Hilts figured it out. Dr. Hilts found out about the “Direct Primary Care” model which allowed him to fulfill his dream of bringing the best healthcare possible to his patients. In addition, his innovative strategies with outside imaging centers, laboratories, and pharmacies bring down the cost to patients in an almost unbelievable way! Could this be the answer to fixing our current healthcare system?

Today we meet Dr. Michael Hilts who introduces us to the Direct Primary Care (DPC) practice model which is rapidly spreading across the country. You’ll hear about innovative ways he uses DPC and other strategies to bring back the spirit of primary care, challenge the current healthcare paradigm, and turn it on its head!

Today on The Lab Report:

4:30 Meet Dr. Michael Hilts
5:50 What is Direct Primary Care and why did Dr. Hilts pivot?
12:20 Labs, medications, imaging = significant cost savings
16:10 The transition out of insurance-based conventional medicine
18:00 Incorporating functional medicine laboratory testing and success stories
24:00 Non-surgical sports medicine – ultrasound, prolo therapy, PFP
29:45 Work with Dr. Hilts
31:40 The Fireball

Additional Resources:

Genova Connect - (PROMO CODE: TheLabReport20 for 20% off GI Effects)

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Progesterone - The Mother of All Hormones?

Tue, 10 Oct 2023 10:00:00 +0000

When it comes to sex hormones, progesterone is the unsung hero. It is actually the precursor to even making estrogen and testosterone. But progesterone is not just a precursor hormone. It is vital for maintaining pregnancy, helps with mood and sleep, works to help regulate the body’s water stores, and so much more.

In today’s episode, we unpack all of the important functions of progesterone, break down its many fates of metabolism, and talk about ways to optimize your hormonal balance.

Today on The Lab Report:

3:30 What is progesterone and where is it made?
5:15 The cholesterol connection
6:55 Circulation and many fates of metabolism
12:50 Functions of progesterone
15:05 High progesterone levels – symptoms and causes
17:05 “Progesterone steal”
20:00 Low progesterone levels – symptoms and causes
24:00 Symphony of hormones and metabolism
25:30 Treating low progesterone, root-cause, synthetic vs. bio-identical BHRT

Additional Resources:

Dr. Joe Feuerstein's website

Rhythm Plus

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Living Young For a Lifetime with Dr. Jeffrey Gladden

Tue, 03 Oct 2023 10:00:00 +0000

Have you ever said to yourself “Hey, I’m doing pretty good for my age”? Well, today’s episode will change everything you thought you knew about aging. Dr. Jeffrey Gladden is not only a renowned expert in longevity medicine but also a cardiologist, author, international speaker, and host of The Gladden Longevity Podcast. His personalized approach, ground-breaking therapies, and team of experts help guide you on a journey toward optimal health, longevity, and performance. Dr. Gladden’s latest book “100 is the New 30 – How Playing the Symphony of Longevity Will Enable Us to Live Young for a Lifetime,” outlines a roadmap to boundless energy while shattering the limitations of traditional aging beliefs.

Today, Dr. Jeffrey Gladden explores the deep dimensions of longevity, the vital role of life energy and purpose in the aging process, and how to embark on your own ‘Hero’s Journey’ in living young for a lifetime.

Today on The Lab Report:

3:30 Meet Dr. Jeffrey Gladden and hear his personal journey to longevity medicine
10:40 The Hero’s Journey and rethinking the aging process
15:00 Start with your pain point
17:15 Aging is exponential – not linear
21:00 How quickly can we alter aging?
23:00 Testing, supplements, diet & lifestyle
26:00 How to use Diet as a tool
28:40 The future of longevity medicine
30:45 Where you can go for more information
32:00 Physical work vs. mindset
35:00 The Fireball

Additional Resources:

Gladden Longevity

Gladden Longevity Shop

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Dr. Joe Feuerstein - The Incredible Cannabinoid System

Tue, 26 Sep 2023 10:00:00 +0000

When people hear the word ‘cannabinoid’, what usually comes to mind is marijuana (also known as cannabis) or CBD oil (cannabidiol). But did you know, the body creates its own natural cannabinoids using the endocannabinoid system? This endocannabinoid system is a mysterious and complex interplay of chemical messengers throughout the brain and body which in essence contributes to our body’s homeostasis. It regulates a broad array of physiological processes including pain, mood, sleep, inflammation, appetite, and more. Rather than relying on marijuana or CBD products, Dr. Joe Feuerstein teaches that there are ways to boost the endocannabinoid system naturally. As a nationally recognized and award-winning physician and researcher in the field of botanical medicine and nutrition, Dr. Joe has co-written a best-selling book on how to do just that.

Today Dr. Joe Feuerstein tells us what the endocannabinoid system is and why you should care. He also outlines various herbal and natural ways to boost the endocannabinoid system for optimal health.

Today on The Lab Report:

4:15 Meet Dr. Joe Feuerstein and hear about his amazing career
10:50 What are cannabinoids and why should we care?
14:05 Natural drivers to optimize the endocannabinoid system
19:30 The interaction between the HPA axis and the endocannabinoid system
21:00 Anecdotal improvements using the Cannabinoid Cookbook
23:00 Omega-6’s, anandamide and 2-AG, ‘cannabinoid resistance,’ chocolate
26:00 Gut-brain axis and the endocannabinoid system
27:40 Endocannabinoid deficiency, Cannabinoid Cookbook, Condition Kitchen
30:50 Using GI Effects actionable intelligence for microbiome modulation
39:20 Joe’s take on trendy diets
42:45 Where can we go to follow and work with Dr. Joe
44:45 The Fireball

Additional Resources:

The Cannabinoid Cookbook

Dr. Joe's Man Diet

Dr. Joe's YouTube channel

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Hunger Hormones - Patti & Michael Talk Leptin and Adipose Tissue

Tue, 19 Sep 2023 10:00:00 +0000

Many of us think of adipose tissue as just a place to store excess fat to be used for energy. However, adipose tissue is very biologically active and secretes some important hormones and mediators called adipokines. These messengers help regulate glucose and lipid metabolism, control hunger, and affect insulin levels. That being said, ALL of our hormones work together like a symphony – cortisol, thyroid hormones, sex hormones, and don’t forget the adipokines.

In today’s episode, we discuss important bioactive messengers created by our fat tissue (leptin and adiponectin), how they affect us systemically, and strategies to optimize them.

Today on The Lab Report:

3:40 Adipose tissue, adipokines, and types of fat
7:40 What are adipokines?
10:25 Adiponectin does great things
13:00 How to increase adiponectin
14:20 Better Know a Biomarker – Leptin!
17:40 Obesity and leptin resistance
19:25 Treating leptin resistance
21:35 Leptin vs. ghrelin
23:15 Adiponectin/leptin ratio

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Microbiome Diversity [Rebroadcast]

Tue, 12 Sep 2023 10:00:00 +0000

The commensal bacteria in the gut microbiome are responsible for so many important functions. Their influence is far-reaching as it relates to overall health. Research shows us that the more diverse that community of bacteria is, the more beneficial it is to systemic health. But what does diversity mean and how do we measure it? There are many calculations used when it comes to diversity of the microbiome, and they can sometimes give differing information. It’s important to understand what’s being measured in order to clinically correlate the result.

In today’s episode, we discuss the industry standard Shannon Diversity Index as measured on Genova’s brand new Microbiomix profile.

Today on The Lab Report:

3:15 Better Know a Biomarker: Shannon Diversity Index
6:00 Evenness and Richness
7:30 Alpha vs. beta diversity
10:05 Who’s Claude Shannon?
13:00 Get Outta Here!
15:50 Simpson vs. Shannon Index
17:40 The numerical score
19:45 Improving the diversity score

Additional Resources:

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Dr. Filomena Trindade - Cardiovascular Disease in Women

Tue, 29 Aug 2023 10:00:00 +0000

There are very few key opinion leaders that hold extensive certifications in functional and integrative medicine who not only lecture, mentor, and teach but also continue to practice full-time and harness decades of clinical expertise like Dr. Filomena Trindade. An internationally sought-after speaker, and mentor to hundreds of clinicians, Dr. Trindade continually scours literature for the latest research on hormonal and metabolic health. Her latest focus has been cardiovascular disease.

On today’s episode, we dive into the latest insights regarding cardiovascular disease in women with Dr. Filomena Trindade. We discuss the interplay between women’s hormones, insulin resistance, and metabolic health.

Today on The Lab Report:

4:20 Meet Dr. Filomena Trindade
6:40 State of the evidence regarding women’s health and cardiovascular disease
11:25 Atypical lipid patterns in hormone dysregulation
14:20 Discrepancies in pain patterns – men vs. women
16:30 Atherogenesis and inflammation in women
19:50 The role of SNPs and hormone regulation
22:45 Perimenopause and menopause mechanisms in heart disease
25:00 Metabolic health and the hormone symphony
30:00 Biomarkers, visceral adiposity, and insulin resistance
35:25 Radiologic scanning, body impedance measurement, and physical exam
38:00 Increasing muscle mass vs. decreasing carbohydrates
41:10 Mentorship for new clinicians
46:30 The Fireball

Additional Resources:

drtrindade.com

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Fatty Acids & Inflammation [Rebroadcast]

Tue, 15 Aug 2023 10:00:00 +0000

In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’

Today on The Lab Report:

3:20 What are eicosanoids?
6:05 Fatty acids and the inflammatory cascade
9:10 Lipoxygenase (LOX) and cyclooxygenase (COX)
10:00 The COX eicosanoids – prostanoids and thromboxane
12:10 Leukotrienes, lipoxins, resolvins, and LOX
13:15 Aspirin, fish oil, and heart disease
16:30 Question of the Day
- How should we measure fatty acids?

Additional Resources:

Essential & Metabolic Fatty Acids - Bloodspot

The omega-3 index as a risk factor for coronary heart disease

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Dr. Dwayne Jackson - Metabolism, Myths, & Motivation

Tue, 08 Aug 2023 10:00:00 +0000

Dr. Dwayne Jackson has spent decades in medicine and physiology. He lectured and taught at some of the finest universities in the world. In addition to academia, Dr. Jackson has been a staple in the fitness industry - both as an athlete and trainer. He is recognized internationally for his award-winning research which has shaped our understanding of chronic stress and its impact on immunity, inflammation, and mental health.

In today’s episode, Dr. Dwayne Jackson combines his vast knowledge of physiology with his long career in the fitness industry to help us cut through some of the noise related to nutrition, supplements, and mental-emotional stressors.

Today on The Lab Report:

4:00 Meet Dr. Dwayne Jackson – his career in academia and his reason for leaving
8:25 Path from dialysis to kidney transplant
14:40 Benefits of creatine supplementation and concern around kidney disease
20:40 The most over-hyped supplements
22:10 Recovery, sustained efforts, and stress on the body
25:40 Beyond protein – micronutrients, antioxidants, and balanced diets for performance
31:45 Endurance athletes, cortisol, gut health, and burnout
34:45 Body dysmorphia in elite athletes
41:00 Beyond athletes - working with patients with chronic illness
45:40 Creating consistency and working with Dr. Jackson
50:00 The Fireball

Additional Resources:

Dr.DwayneJackson.com

@drdnjackson

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Amber Shaw - Consistency and Confidence for Middle-Aged Women

Tue, 01 Aug 2023 10:00:00 +0000

Amber Shaw is a Mind & Body Transformation Expert and the Founder of The Wellness Revolution. She works with women over the age of 40 to empower them to rediscover their confidence and create a sustainable lifestyle. Amber’s approach fosters consistency, accountability, and kindness. Women can be quite hard on themselves rather than show self-love. Shifting hormones, the demands of family and career, and a very confusing diet landscape can all be difficult to navigate. This is where Amber Shaw chose to build her career.

On today’s episode, Amber Shaw talks about helping women heal their relationship with food and themselves while empowering them to transform their lives, love their bodies, and create lasting results.

Today on The Lab Report:

3:30 Meet Amber Shaw and hear her inspiring story
13:45 Raising children in a body-shame culture
17:10 Kindness, self-love, and shifting that mentality
21:00 Stop tying weight and metrics to self-esteem
23:40 Fostering consistency, not perfection
28:40 Avoiding diet camps, calories in – calories out, deprivation
33:00 Menopause, peri-menopause – old tricks no longer work
37:00 Work with Amber Shaw – sorry guys, women only
39:30 The Fireball

Additional Resources:

AmberShaw.com

The Wellness Revolution Podcast

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Dr. Elizabeth Raskin - Holistic Support for the Surgical IBD Patient

Tue, 25 Jul 2023 10:00:00 +0000

Inflammatory bowel disease or IBD is an umbrella term to describe chronic inflammatory disorders of the GI tract – most commonly Crohn’s disease and ulcerative colitis. Medications, nutritional therapies, and lifestyle modifications are all used to control symptoms and keep patients in remission. However, sometimes surgical intervention is needed. Dr. Elizabeth Raskin is an award-winning colorectal surgeon and the Surgical Director of one of the leading IBD programs in the country – the Hoag Margolis Family IBD Program. This team-based, multidisciplinary approach to helping patients with IBD addresses the medical, nutritional, and psychosocial components to these diseases.

Today we speak with Dr. Elizabeth Raskin, one of the leading colorectal surgeons in the country. We hear about her unique approach to IBD - combining nutrition, functional medicine, mental, spiritual, and emotional support for better patient outcomes.

Today on The Lab Report:

3:30 Meet Dr. Raskin and hear about her dedication to healing the colon
9:30 Nutritional challenges with IBD patients
14:40 Pre-habilitation before surgery
17:05 Post-op advice for primary care clinicians
20:55 IBD prevalence
22:50 The microbiome and surgery – pre and post op support
30:20 Triggers of IBD
33:50 Personalized approach to Crohn’s disease
38:00 Endurance athletics and the gut
46:45 The Fireball

Additional Resources:

Hoag Margolis Family IBD Program

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Dr. Lauryn Lax - From Barely Surviving to Thriving

Tue, 18 Jul 2023 10:00:00 +0000

Dr. Lauryn Lax is a Doctor of Occupational Therapy, Clinical Nutritionist, Functional Medicine Practitioner, Certified Personal Trainer, author, and journalist. With over 20 years of clinical and personal experience, she’s on a mission to help patients feel good - inside and out. But what sets Dr. Lauryn apart is her life-long journey of illness and healing. It’s a story of joy, pain, bravery, and survival. This journey has resulted in an empathic heart, a holistic philosophy, and tools that can transform lives.

In today’s episode, Dr. Lauryn Lax shares her incredible story of personal healing to help heal others. We discuss the gut’s relationship to mental-emotional state, breaking free of strict food rules, and how to use German New Medicine to uncover true root causes.

Today on The Lab Report:

4:50 Meet Dr. Lauryn Lax
6:00 The Story
21:30 Lessons learned – new insights
23:30 Food freedom and clean eating
28:30 Where to start? Nourish the gut
34:00 Mental-emotional work
39:00 The real root cause: German New Medicine
44:50 The Fireball

Additional Resources:

dr.lauryn.com

Dr. Lauryn's books

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Nonpathogenic Parasites?

Tue, 11 Jul 2023 10:00:00 +0000

In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don’t need to be treated.

Today on The Lab Report:

3:50 Prevalence and transmission of parasites
6:45 What is a parasite? Are there nonpathogenic parasites?
8:10 3 main classes of parasites
10:20 Detecting parasites in the stool
13:10 Nonpathogenic parasites
- Chilomastix mesnili, Endolimax nana, Entamoeba coli, Entamoeba dispar, Entamoeba hartmanni, Entamoeba polecki, Iodamoeba buetschlii

16:50 Potentially pathogenic parasites
19:25 Question of the Day
- Why doesn’t Genova offer sensitivities for parasites on the GI Effects?

Additional Resources:

Acne Quick Solution Guide

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Methane & The Microbiome

Wed, 05 Jul 2023 10:00:00 +0000

Methane is often in the news as a greenhouse gas, but guess what? Your gut microbiome also makes it. Specific organisms called methanogens are responsible for the production of methane in the GI tract. High levels of methane can locally affect gut motility and contribute to constipation. In addition to constipation, methane affects gut immunity and has some interesting systemic implications.

In today's episode, we talk about the effects of methane production in the GI tract, various ways to assess it, and what you can do to treat it when levels get too high.

Today on The Lab Report:

2:45 Glory and Shade
5:20 Gas and the microbiome
6:30 Archaea vs. bacteria
8:30 Cows and methane
9:15 Methanogenesis in the GI tract and disease associations
12:15 Breath testing and IMO
14:40 Methane Dysbiosis on GI Effects
18:35 Whole-genome sequencing with Microbiomix
19:40 Treating high methane
22:45. Question of the Day

What about low methane?

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Acne - Beyond Skin Deep with Lienna May

Tue, 27 Jun 2023 10:00:00 +0000

Living with acne, or any chronic skin condition, can be incredibly distressing. Skin is the largest organ in our body and is forward-facing for the world to see. Conventional medicine offers creams, gels, and antibiotics. But in personalized medicine, we know that acne is multi-factorial and has several root causes. Lienna May is a board-certified clinical nutrition specialist who is dedicated to helping patients struggling with acne by developing personalized lifestyle and nutrition programs for patients to reclaim their health and clear their skin.

In today’s episode, Lienna May discusses the root causes of acne and outlines her holistic approach for long-term relief.

Today on The Lab Report:

3:35 Meet Lienna May and hear about her passion for treating acne
8:45 Gut health and acne
11:40 Stress, cortisol, and skin
15:50 Nutritional deficiencies and food triggers
21:20 Sugar, acne, and continuous glucose monitoring
24:30 Exercise, movement, and acne
28:00 Types of acne and triggers
30:35 The Fireball

Additional Resources:

Lucky Avocado Nutrition

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Balance Your Life, Balance Your Hormones with Lacey Dunn

Tue, 20 Jun 2023 10:00:00 +0000

Lacey Dunn is a functional medicine dietitian and personal trainer who is passionate about helping women look and feel their best. Lacey is the founder of Uplift Fit Nutrition (an online platform for personalized support), host of the Uplift Fit Nutrition Podcast, and author of the book “The Women’s Guide to Hormonal Harmony – How to Rebalance Your Hormones, Master Your Metabolism, and Become the Boss of Your Own Body.” Many of her clients call her their “Hormone Fairy Godmother.”

In today’s episode, Lacey Dunn gives a masterclass on the functional approach to balancing hormones and balancing your life.

Today on The Lab Report:

3:30 Lacey Dunn discusses her journey to hormonal balance
8:55 Symptoms, clinical presentations, and root cause
11:30 Where to start? Adrenals, stress, and taking a breath
14:00 Testosterone in women
17:30 The role of diet in hormonal balance
21:10 Microbiome and HPA axis
23:20 Obstacles and behavior change
25:15 The Women’s Guide to Hormonal Harmony – for men?
27:25 The Fireball

Additional Resources:

Uplift Fit Nutrition

The Women's Guide to Hormonal Harmony

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Dr. Mike T Nelson - The Fundamentals of Flexibility & Resilience

Tue, 13 Jun 2023 10:00:00 +0000

Dr. Mike T Nelson is an exercise physiologist, researcher, speaker, author, personal trainer, and coach. In the world of sports optimization, his approach to coaching world-class athletes is innovative and science-driven. Dr. Mike’s years of research and coaching experience, paired with an open mind to new ideas, have garnered his clients amazing results. A teacher at heart, he also offers several key training opportunities and certifications to help athletes, coaches, and healthcare professionals to fully understand the physiology that drives meaningful changes.

In today’s episode, Dr. Mike T Nelson outlines the basics of physiologic flexibility and ways to train our metabolism to become more resilient and anti-fragile.

Today on The Lab Report:

3:00 Mike T Nelson is back and so is the Flex Diet certification
7:00 Diet Wars and Keto
9:45 Physiologic flexibility and homeostatic regulators
14:00 Regulating respiration and pH
20:15 Controlling temperature, metabolism, and mental fortitude for resiliency
27:15 Advanced recovery methods and wearable devices
38:15 Volume vs. intensity
40:20 The Fireball

Additional Resources:

miketnelson.com

Physiologic Flexibility Certification Course

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Patti & Michael Put the Chrome in Chromatography [Rebroadcast]

Tue, 30 May 2023 10:00:00 +0000

Here at Genova, we are incredibly proud of the high standards set by our laboratory director and the brilliant minds that work in the lab to keep things running smoothly. As clinicians, and consumers, many of us don’t give the inner workings of the lab a second thought. We take for granted that samples are sent, results are generated, and we can clinically act on those findings. Most of our profiles rely on several different laboratory methodologies to put the whole story together. One of those methods is called Chromatography – and clinicians don’t fully understand what that actually means.

In today’s episode, we call on our friend Ashley Gibbon – one of the smartest minds in laboratory science – to help us understand what chromatography is and why it is so vital to Genova testing.

Today on The Lab Report:

· 7:10 Ashley Gibbon defines chromatography

· 14:15 Organic acids and Separation science

· 16:15 The instrument – columns, beads, mobile and stationary phases

· 19:25 Detectors and mass spectrometry

· 23:15 Liquid vs. Gas chromatography

· 26:00 Maintaining the beads to preserve peaks

· 28:05 Quadrupoles, Sensitivity and specificity of detectors, and quantification

· 31:00 Area under the curve, inhibitors and interferents, coefficient of variance

· 34:00 Question of the Day

What is clinical vs. analytical sensitivity/specificity?

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Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net.

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Why Take B-Vitamins?

Tue, 23 May 2023 10:00:00 +0000

The importance of B-vitamins can not be overstated. They are used as cofactors in just about every biochemical pathway in the body. Overt B-vitamin deficiencies are not common, though many diet and lifestyle factors can influence levels and lead to insufficiencies. Symptoms of B-vitamin deficiencies are widely variable and not often recognized. Many people choose to take B-vitamin supplements. But why? Should we all be taking a B-complex vitamin? Is it possible to take too much?

On today’s show, we do a high-level overview of B-vitamins. We talk about the importance of each B-vitamin in the body, symptoms of insufficiency, and why you might need to supplement.

Today on The Lab Report:

3:55 What is a vitamin?
5:15 Naming convention of B-vitamins
7:55 Biochemical cofactors
9:35 Thiamine (Vitamin B-1)
11:00 Riboflavin (Vitamin B-2)
11:55 Niacin (Vitamin B-3) and Pellagra
13:55 Pantothenic Acid (Vitamin B-5)
14:50 Pyridoxine (Vitamin B-6)
17:15 Biotin (Vitamin B-7)
20:10 Folate (Vitamin B-9)
21:35 Cobalamin (Vitamin B-12)
24:15 Supplementation

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Dr. Michael Lutter - Precision Psychiatry and Eating Disorders

Tue, 16 May 2023 10:00:00 +0000

Eating disorders have long been stigmatized and treatments have been limited – until now. Dr. Michael Lutter is a medical psychiatrist and PhD researcher working toward new solutions and therapies to offer hope for those suffering with psychiatric illness. Using the latest advancements in genetic and metabolic testing, Dr. Lutter helps patients understand how their unique biology plays a role in their psychiatric disease and tailors treatment based on these findings. His results are astounding. His latest book GIFTED: Genetic Information for Treating Eating Disorders outlines his novel approach.

In today’s episode, Dr. Michael Lutter discusses precision psychiatry and the role of genetic and metabolic testing for personalized results.

Today on The Lab Report:

5:30 Meet Dr. Michael Lutter and learn about whole exome sequencing
10:15 Genetic mutations in eating disorders and metabolic effects
14:00 Nutritional therapy and the NutrEval in psychiatry
18:00 Using the GIFTED approach in practice for eating disorders
23:30 Removing stigmas and shifting the paradigm
27:55 Other testing -Vitamin D, the microbiome, hormones, oxidative stress, and the brain
32:30 Genetic mutation overlaps with OCD and addition
35:00 Dr. Lutter’s long path and getting the field to catch up
41:30 The Fireball

Additional Resources:

Precision Psychiatry

GIFTED: Genetic Information For Treating Eating Disorders

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Jaclyn Sklaver - Sports Nutrition as a Game Changer

Tue, 09 May 2023 10:00:00 +0000

Elite professional athletes are often held up as the healthy ideal. But many of us don’t realize the wear and tear and physical toll that sport takes on the body. That’s where Jaclyn Sklaver comes in. As a nationally recognized sports nutrition specialist, she combines functional medicine with personalized nutrition to create coaching plans for long-term success.

Today we meet Jaclyn Sklaver and hear about her unique Athleats Nutrition program. Whether you are an elite athlete or an everyday gym enthusiast, Jaclyn’s team at Athleats Nutrition can help you reach peak performance, optimal body composition, and realize strength and recovery goals.

Today on The Lab Report:

4:10 Jaclyn Sklaver on challenges and variables in helping elite athletes
7:30 Quality calories and food volume in training
9:45 Metabolic dysfunction, injury and repair, hormonal imbalances
12:50 Nutrition as a secret weapon
15:15 Functional nutrition and microbiome testing
20:45 Weight loss advice
23:40 Training and the importance of recovery
31:30 Athleats Nutrition
33:10 The Fireball

Additional Resources:

Athleats Nutrition

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Addressing Autoimmunity with Dr. Akil Palanisamy

Tue, 02 May 2023 10:00:00 +0000

Autoimmune conditions are exponentially on the rise. Toxic exposures, declining food quality, stress, and unhealthy lifestyle factors are all contributors. Dr. Akil Palanisamy is a Harvard-trained physician, author, and holistic medicine expert in integrative and functional medicine. Through years of experience in root-cause medicine, he’s helped thousands of patients find relief and remission of autoimmune diseases. Dr. Akil’s new book The T.I.G.E.R. Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity outlines his approach using the best of conventional and holistic medicine.

In today’s episode, we meet Dr. Akil Palanisamy. We discuss his treatment strategies and successes in addressing autoimmunity as outlined in his new book The T.I.G.E.R. Protocol.

Today on The Lab Report:

3:45 Akil Palanisamy combines integrative and holistic medicine with Ayurveda
7:20 Common misconceptions and the paleovedic diet
8:25 The rise of autoimmunity – remission vs. cure
10:35 The T.I.G.E.R. Protocol – autoimmunity treatment and prevention
14:06 Exposome and detox
15:35 Infection, gut health, and autoimmunity
20:00 Phase 1 - Phase 2 Diet, processed food quality
24:30 Rest, recovery, and stress
26:00 Success stories, mitigating pharmaceuticals, remission
27:35 The Fireball

Additional Resources:

The T.I.G.E.R. Protocol

doctorakil.com

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Is Melatonin A Master Hormone?

Wed, 26 Apr 2023 10:00:00 +0000

Melatonin is known as the sleep hormone, but it is SO much more than that. Yes, it is produced in the brain and controls the day/night cycle. However, what many people don’t realize is that is also produced in other places in the body such as the gastrointestinal tract, skin, bone marrow, and more where it exerts important local effects that are important for health. Additionally, it is a powerful antioxidant making it crucial in mitigating harmful free radical damage which is implicated in aging and many chronic diseases.

In today’s episode, we break down the synthesis, physiology, and metabolism of melatonin. We discuss not only melatonin’s role in day/night cycles, but its important systemic effects to promote health and mitigate harmful risks.

Today on The Lab Report:

2:40 Melatonin is an important hormone
6:30 Break it down: melatonin and day/night cycles
9:00 Babies and sleep
10:30 Suprachiasmatic nucleus and blindness
11:30 Sleep, shift workers, jet lag
14:30 Systemic antioxidant effects
16:10 Melatonin in the GI tract
17:40 Brain health, cancer, cardiovascular disease, and other hormones
21:00 Supplementation and side effects
23:25 Question of the Day
- Does melatonin supplementation affect nutrition testing?

Additional Resources:

Comprehensive Melatonin Profile

Integrative and Functional Nutrition Academy

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Dr. Anna Lembke - The Dopamine Hit and Addiction

Tue, 18 Apr 2023 10:00:00 +0000

In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways.

Today on The Lab Report:

3:00 Anna Lembke explains dopamine and the reward system
6:05 Dopamine hits in today’s society
10:40 Moderation vs. Abstinence
13:30 Social media and children
15:00 Does society award addictive behavior?
18:45 Long term dopamine dysfunction and Parkinson’s disease
22:00 Parenting in the digital age
27:20 The Fireball

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect.

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Hormone Detoxification with Dr. Sheila Dean

Tue, 11 Apr 2023 10:00:00 +0000

Dr. Sheila Dean is one of the nation’s premier integrative nutritionists. She is a co-founder of the Integrative and Functional Nutrition Academy and has practiced functional medicine for two decades. Her insight has not only changed the lives of many patients, but her teaching and mentoring has inspired and empowered a new generation of nutrition specialists and health professionals.

In today’s episode, we welcome Dr. Sheila Dean back to the show for a masterclass in hormone detoxification – including the importance of testing and clinical pearls using nutritional therapeutics.

Today on The Lab Report:

3:20 Dr. Dean is back with a detox pathway recap
7:20 Importance of hormone detox
11:10 The need for testing metabolites
16:30 Clinical pearls for optimizing estrogen metabolism
21:45 Role of Genetic SNPs and the microbiome
28:30 IFNA program highlights
30:35 The Fireball

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Next Level Performance with Pratik Patel

Tue, 04 Apr 2023 10:00:00 +0000

After years of working with collegiate and professional athletes, Pratik Patel has gained significant wisdom when it comes to optimal health. The continuous strain placed on the body of professional athletes can take its toll. Keeping those athletes healthy is no easy task. Pratik has worked with some of the most elite athletes in the world.

In today’s episode, dietitian and conditioning coach, Pratik Patel, reflects on his years in the NFL and imparts his wisdom regarding nutrition, hydration, strength training, recovery, and overall athletic health.

Today on The Lab Report:

4:00 Pratik Patel on great athletes vs. elite athletes
8:15 Genetics and work ethic
11:20 Lab testing, does fitness = health?
19:25 Hydration, thirst, and performance
25:00 Climate adaptability and electrolytes
31:00 Caffeine and hydration
34:00 Diet principles for athletes
38:35 Training pitfalls
41:10 Recommended supplements
49:35 Working with Pratik
51:00 The Fireball

Additional Resources:

Instagram: @pratikxpatel

Twitter: @PratikxPatel

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Stool Testing - Frequent Flubs

Tue, 28 Mar 2023 10:00:00 +0000

Interpreting the GI Effects Comprehensive Stool Profile can be complicated. Here at Genova, we do a lot of educational outreach, one-on-one consults, group consults, and we compile lots of support materials to help – support guides, report review videos, charts, and more. Even with that, some clinicians still continue to misinterpret biomarker results and draw conclusions on their own which may not be valid.

In today’s episode, we dive into some of the GI Effects’ most common interpretation mistakes to dispel the rumors and help clinicians find the best outcomes for their patients.

Today on The Lab Report:

5:00 Products of Protein Breakdown and digestion/absorption
8:30 Commensal bacteria - below detectable limits?
12:20 When to treat a potential pathogen?
13:15 Salmonella pronunciation and etymology
19:15 Misusing Add-ons
22:50 Beta-glucuronidase and calcium-d-glucarate

Additional Resources:

GI Effects Support Guide

Commensal Bacteria Chart

Parasitic Organisms Chart

Pathogenic Bacteria and Yeast Chart

GI Effects Report Review Video

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Branched-Chain Amino Acids [Rebroadcast]

Tue, 21 Mar 2023 10:00:00 +0000

Amino acids are the building blocks of life. They can be categorized as essential or nonessential. Essential amino acids must come from the diet, while nonessential amino acids can be made in the body. Of the essential amino acids, there is a subgroup called the ‘branched-chain amino acids (BCAAs).’ There are three BCAAs: leucine, isoleucine, and valine. These three amino acids have different molecular structures and important metabolic activity.

In this episode, we discuss the clinical importance of BCAA and how to interpret BCAA levels in context with organic acids.

Today on The Lab Report:

2:50 Let’s Define Some Terms!
5:10 The unique metabolism of BCAAs
6:30 BCAAs effects on the brain, muscle, and insulin resistance
12:30 What do we think we know?
- BCAAs and immunity
16:10 Measuring and interpreting amino acid patterns
17:55 Relating BCAA levels to urinary organic acids
21:00 Logical Speculation: Urinary alpha-keto acids and ketosis

Additional Resources:

Genova Connect - Metabolomix+

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Metabolomix+ Masterclass

Tue, 14 Mar 2023 10:00:00 +0000

In last week’s episode, we did a high-level review of nutrient testing – who might need it and why. We also introduced you to Genova’s Metabolomix+ profile. This nutritional profile is a non-invasive at-home collection with easy, actionable nutrient recommendations you can start implementing right away tailored for your personal metabolic fingerprint!

Today we dive a bit deeper into the biochemistry and biomarkers that are measured on the Metabolomix+ profile which contribute to the nutrient recommendations. Functional assessments, organic acids, amino acids, fatty acids, oxidative stress, and more!

Today on The Lab Report:

3:15 Recap of last episode Metabolomix overview and introducing the MHR Masterclass
6:00 Krebs Cycle and cellular energy
8:45 Organic Acids and functional assessments
11:20 Amino acids – essential, non-essential, and amino acid metabolism
14:30 Essential and Metabolic Fatty acids
16:10 Better Know a Biomarker
- DGLA and the inflammatory cascade
23:15 Urine Toxic Elements

Additional Resources:

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Patti & Michael on Nutrient Testing

Tue, 07 Mar 2023 11:00:00 +0000

We know nutrition is important. But with all of the confusion around different diet camps out there, (Mediterranean, paleo, vegetarian, keto) many of us don’t know where to start. How do we know if we’re getting proper nutrition to keep us healthy? Are you keeping up with how your body uses nutrients due to exercise, growth, or wound healing? Is a nutrient insufficiency causing your depression or fatigue? Are you setting yourself up for cellular stresses and potentially chronic disease? Food diaries can help but sometimes they fall short. Here’s where testing can help.

Today we discuss the power of Genova’s Metabolomix+. This nutritional profile is a non-invasive at-home collection with easy, actionable recommendations you can start implementing right away tailored for your personal metabolic fingerprint!

Today on The Lab Report:

3:15 Who needs a nutrition test?
6:00 Intro to the Metabolomix+ Profile
8:45 Nutrition underpins bodily functions
12:25 Personalized nutrient recommendations
14:40 Education and food sources on the report
17:20 Question of the Day
- Do I have to stop my supplements to do testing?

Additional Resources:

Genova Connect - Metabolomix+

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Rachel Gregory - The Power of Periodization

Tue, 28 Feb 2023 11:00:00 +0000

Rachel Gregory is a board-certified nutrition specialist, strength and conditioning coach, podcaster, author, and founder of MetFlex Life. She inspires and guides women to transform their lives through proper education, awareness, and accountability in nutrition and fitness. Through her unique approach, she helps women all across the world learn how to ditch the restrictive all-or-nothing mindset and instead thrive through the power of metabolic flexibility.

In today’s episode, Rachel Gregory returns to the show and we catch up on her amazing coaching programs, education, and her latest insights relating to women’s health.

Today on The Lab Report:

4:00 Rachel Gregory is back, and she’s been busy!!
8:35 Change of focus to holistic women’s health and common pitfalls
15:00 Using keto as a tool vs. pulsating carbs
18:40 Long-term planning and periodization
21:00 Training to build muscle instead of weight loss
24:25 Wearable devices
27:05 The role of carbohydrates
29:40 Correctly building muscle
37:40 Will there be another book?
38:50 The Fireball

Additional Resources:

MetFlex Life

TheFlexFam

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Phytoestrogens

Tue, 21 Feb 2023 11:00:00 +0000

There is a lot of debate and controversy when it comes to nutrition. Many of us are entrenched in our diet camps and with that, some nutrients are unfairly vilified. One such nutrient is phytoestrogen. Phytoestrogens are chemical compounds found in plants that can stimulate and block estrogen receptors in the body – a concept that is poorly misunderstood.

In today’s episode, we talk about phytoestrogens and their metabolic function. Should they be classified as anti-nutrients? Are they dangerous or protective?

Today on

3:20 Phytoestrogens and anti-nutrients
5:07 Types of phytoestrogens and common food sources
7:55 Are we actually eating estrogen?
9:30 Constituent vs. whole plant
12:00 Hormone-related risks and PMS
13:32 Cardiovascular disease
14:30 Logical Speculation – Just eat food
17:00 Tumors, bone, brain, and skin

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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Dr. Sara Gottfried on Women, Food, & Hormones [Rebroadcast]

Tue, 14 Feb 2023 11:00:00 +0000

Dr. Sara Gottfried is a key opinion leader as it relates to hormone balance. As a New York Times best-selling author, practicing medical doctor, researcher, university professor, and popular speaker, she offers an evidence-based approach to hormones and nutrition. Her upcoming book “Women, Food, & Hormones” outlines the latest research combined with her vast clinical experience to help women lose weight and get to the root cause of hormonal complaints.

In today’s episode, we discuss the interconnection of hormones with diet and the microbiome, and we hear about her approach to bio-identical hormone replacement therapies.

Today on The Lab Report:

3:20 Meet Dr. Sara Gottfried and hear her journey to root cause medicine
8:50 Diet, metabolism, and hormones
12:45 Pre-diabetes and continuous glucose monitoring
14:35 Heart rate variability testing and cortisol
17:00 When to use bio-identical hormone replacement
20:20 Cortisol’s effects on other hormones
22:25 The role of the microbiome
25:25 Dosing and timing of hormone replacement
30:50 How you can work with Dr. Gottfried
31:50 The Fireball

Additional Resources:

saragottfriedmd.com

Marcus Institute of Integrative Health

Women, Food, & Hormones

The Hormone Reset Diet

The Hormone Cure

Brain Body Diet

Younger

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Death by Lectins?

Tue, 07 Feb 2023 11:00:00 +0000

If there’s one thing we’ve learned, the world of diet and nutrition is full of controversy. People are deeply entrenched in their diet camps and routinely, various nutrients become vilified. Though, it’s never that simple. Today we take on the topic of antinutrients. Antinutrients are plant-made chemicals that bind and potentially prevent the absorption of important vitamins and minerals. The most controversial of these antinutrients is lectin. Lectins are found in beans, peanuts, tomatoes, potatoes, lentils, and many other foods. Some medical influencers advise removing these foods from the diet completely. But is that really necessary?

In today’s episode, we discuss the controversy around antinutrients - specifically lectins. Are they as harmful as people think?

Today on The Lab Report:

3:00 Food controversies and brass tacks
5:40 What is an antinutrient?
8:00 Lectins and their biochemical effects
11:00 Cooking and denaturing lectins
13:15 Physical symptoms and leaky gut - the research
17:00 Confounding variables
19:00 The middle ground

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To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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All Things Ayurveda with Dr. Gillian Ehrlich

Tue, 31 Jan 2023 11:00:00 +0000

Ayurvedic medicine is one of the oldest holistic healing systems. It was developed thousands of years ago in India and is still practiced throughout the world both exclusively and in conjunction with Western medicine. Ayurveda works to find balance between our innate constitution and how we adapt to our world. Dr. Gillian Ehrlich is extensively trained in conventional and functional medicine but also weaves the art of ayurveda through each patient encounter helping to treat the whole patient – body, mind, and spirit.

In today’s episode, Dr. Gillian Ehrlich discusses the principles of Ayurveda. We learn how she puts science and art together toward practicing true transformational medicine.

Today on The Lab Report:

4:20 Gillian Ehrlich on her path to Ayurvedic medicine
9:30 The three Doshas – Vata, Pitta, Kapha
16:25 Finding your dosha
21:40 Tailoring interventions for each dosha
29:05 Lab testing, ama, and the importance of digestion
37:30 NeuroVeda Health – a unique medical practice
49:45 The Fireball

Additional Resources:

NeuroVeda Health

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Dr. Molly Maloof & The Spark Factor

Tue, 24 Jan 2023 11:00:00 +0000

Dr. Molly Maloof has been leading and innovating in the personalized medicine space for years. Her entrepreneurial spirit lends itself to looking at healthcare in very forward-thinking ways. After years of research and clinical practice, she’s finally put all of her knowledge down on paper and is soon to release her new book, “The Spark Factor: The Secret to Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever.”

In today’s episode, we meet Dr. Molly Maloof and discuss her unique approach to health, wearable devices, biohacking tips, and the power of “The Spark Factor.”

Today on The Lab Report:

4:30 Molly Maloof on her path to personalized medicine
11:30 The Spark Factor
17:45 Wading through biohacking for women - fasting, diets, CGM, HRV
22:55 Using laboratory testing in practice
26:40 Wearable devices – pros/cons
32:40 Listening to intuition, inner wisdom, and body signals
37:55 Love, social connection, and optimal health
45:25 The Fireball

Additional Resources:

The Spark Factor

Dr. Molly Maloof

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The Benefits of Berberine

Tue, 17 Jan 2023 11:00:00 +0000

Today on The Lab Report:

4:00 Berberine – not an herb – where does it come from?
6:55 Overall gut modulator, skin health, and detox
13:05 Metabolic dysfunction – blood glucose, protein, lipids
14:50 Cardiovascular effects and heart health
16:00 Contraindications and safety considerations
18:00 What’s in a name?

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Starch - The Good, The Bad, and The Bland

Tue, 10 Jan 2023 11:00:00 +0000

Diet and nutrition are a cornerstone of health and wellness. Small changes can have big impacts! With so much research and so many opinions, many people still struggle with what they should be eating. When looking for help, it’s difficult to wade through the various schools of thought since people become entrenched in their dietary camps: keto, carnivore, vegetarian, Mediterranean, etc. Recent trends have been leaning toward decreasing or eliminating carbohydrates in general. But, if history has taught us anything, vilifying specific food groups can have consequences. Are all carbs bad? If our industry espouses a personalized approach to health, shouldn’t that include diet?

In today’s episode, we discuss the good and bad of carbohydrates – and more specifically starch. We discuss the different types of starch and the fact that not all carbs are created equally

Today on The Lab Report:

2:25 Why are we vilifying carbohydrates?
5:00 Not all carbs are created equally – let’s talk starch basics
6:45 Starch digestibility and glycemic index
8:30 Slowly digestible and resistant starch
12:00 Effects on the microbiome
15:15 Starchy foods and Retrogradation
19:00 Glycoalkaloids, potato safety, corn starch
21:10 Question of the Day
- Is there anything nutritious in a potato?

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A Year In Review: 2022

Fri, 30 Dec 2022 11:00:00 +0000

Another calendar year in the books, and The Lab Report did not disappoint. Incredible interviews with some of the brightest minds in the health care industry, complex medical topics made easy, games, jingles, and loads of fun. As we approach the New Year, it’s a great time to listen back to some of the highlights (and lowlights) from the podcast throughout 2022.

On today’s episode, Michael takes a walk down memory lane while Patti is away on vacation – though, despite the distance you can’t separate the dynamic duo.

Today on The Lab Report:

2:15 Michael is making his own episode– Better Call Patti!!!
5:30 Jingles, sound effects, and Travis
9:00 Metabolic Health and New Year Resolutions
20:30 Michael’s random life advice, flubs, and the importance of staying curious
30:30 The Lab Report reviews by audience & guests
33:00 Dynamic duo general insanity/nonsense and Michael’s early onset grumpiness
41:30 It's not all shenanigans – we do some important interviews
49:50 Games, grooves, and lack of gravitas
60:00 Practical tips and profundity from our guests
63:30 We talk a lot about animals. Also, we apparently hate insects
69:20 Fireball Fun

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Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

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A Holiday Hodgepodge

Tue, 20 Dec 2022 11:00:00 +0000

Today on The Lab Report:

5:00 Kentucky Fried Christmas
7:00 The Christmas Pickle
8:55 Pooping logs, yule goats, & frankincense
14:30 Christmas disease game
17:30 Santa Claus towns
20:00 ‘Twas the Night Before Christmas

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Microbiome & Movement with Dr. Sara Campbell

Tue, 13 Dec 2022 11:00:00 +0000

The roles of nutrition, hormones, and muscle physiology have been well established when it comes to improving athletic performance. But what if optimizing the gut microbiome is a crucial missing piece? This is exactly where Dr. Sara Campbell and her team at Rutgers University focus their research. Dr. Campbell pioneered studying the connection between the microbiome and movement over a decade ago – with fascinating results.

In today’s episode, Dr. Sara Campbell discusses the latest research on the effect of exercise on our gut microbiome, how the microbiome can enhance athletic performance, and the emerging paradigm shift highlighting the role of microbial metabolites.

Today on The Lab Report:

4:30 Meet Dr. Sara Campbell
8:20 The bidirectional axis between gut bacteria and exercise
14:00 Parsing out the noise in designing research studies
18:00 Antibiotics effects on exercise
21:04 Aerobic exercise, resistance training, HIIT and the microbiome
26:00 Targeted probiotics for athletic performance?
29:30 Bacteria vs. their metabolites
40:10 The Fireball

Additional Resources:

Dr. Sara Campbell

Genova's Microbiomix Profile

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Microbiome Metagenomics with Dr. Ken McGrath

Tue, 06 Dec 2022 11:00:00 +0000

As technology evolves, so too does our understanding of the gut microbiome. Until now, we’ve only seen the tip of the iceberg. Metagenomics offers us the ability to assess the complete microbiome as well as its potential function. This is the technology that powers Genova’s new Microbiomix stool profile and we’ve partnered with Microba Life Sciences – a world leader in microbiome metagenomic analysis based in Australia. As Microba’s Clinical Solutions Manager, Dr. Ken McGrath combines his expertise in molecular genomics with the clinical application of this technology.

Today, we speak with an industry-leading expert in microbiome research, Dr. Ken McGrath, who explains all things metagenomics, and what we’re now learning (and unlearning) about the gut microbiome.

Today on The Lab Report:

3:15 Meet Dr. Ken McGrath
8:15 16s vs. whole genome sequencing metagenomics
16:20 Taxonomy and continually changing organism names
26:20 Microbes vs. Metabolites – total paradigm shift
32:00 Is Dysbiosis even a thing!?
33:45 Parasites, Yeast, and Metagenomics
39:20 Human genomics vs. bacterial genomics
45:30 Global microbiome differences
51:50 The Fireball(s)

Additional Resources:

Microba

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Dr. Jill Carnahan

Tue, 29 Nov 2022 11:00:00 +0000

If you’ve never heard Dr. Jill Carnahan tell her personal story, you’re about to hear an inspiring and powerful episode. In the face of recurrent and unexpected illness, Dr. Jill never gave up. She continues to find resilience through functional medicine, science, and faith. With that, Dr. Jill uses all of the knowledge and wisdom she’s gained along the way to help patients all over the world.

In today’s episode, Dr. Jill Carnahan inspires us all with her story of resilience. She also offers practical clinical advice that has helped her and many patients on their healing journeys.

Today on The Lab Report:

2:40 Meet Dr. Jill Carnahan and hear her journey
10:30 Illness as a teacher, vulnerability, and the power of telling the story
16:30 Mold toxicity – signs and symptoms
19:05 Mold remediation and practical therapeutic steps
23:10 Recovery, long-term symptoms, and resilience
24:35 Inflammatory Bowel Disease – clinical pearls
31:30 Upcoming book and documentary!
36:20 The Fireball

Additional Resources:

JillCarnahan.com

Unexpected: Finding Resilience through Functional Medicine, Science, and Faith

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Attitude of Gratitude

Tue, 22 Nov 2022 11:00:00 +0000

On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain.

Today on The Lab Report:

3:10 Fun facts about Thanksgiving
7:35 Gratitude interventions and health

11:15 Strategies to prevent holiday weight gain
14:30 Keto, Vegan, Carnivore, Omnivore holiday dinner menus
16:45 Kitchen Cook-cophany!

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Mastering Menopause with Esther Blum

Tue, 15 Nov 2022 11:00:00 +0000

Esther Blum is the industry expert when it comes to empowering women during the menopausal transition and beyond. As an integrative dietician, she’s helped thousands of women master menopause through nutrition, hormones, lifestyle, and self-advocacy. Her approach works and her client results speak for themselves.

In today’s episode, Esther Blum offers her “Meno-Laws” - practical tips for peri- and menopausal women. We talk nutrition, hormone replacement, sleep, the right kind of exercise, and how to beat menopausal weight gain.

Today on The Lab Report:

4:10 Meet Esther Blum and empowering women for self-advocacy
8:35 Meno-laws and nutrition strategies for menopause
12:05 Cortisol, carbs, keto, and hot flashes
14:25 Insomnia and sleep hygiene
16:00 Exercise, weight gain, and the Meno-pot belly
20:20 Bio-identical hormone replacement therapy
24:00 Herbal supplements for hormone support
25:15 The importance of testosterone for women
29:30 Gut health and menopause
31:00 The Fireball

Additional Resources:

estherblum.com

See Ya Later, Ovulator!

Cave Women Don't Get Fat

The Eat, Drink, and Be Gorgeous Project

Secrets of Gorgeous

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Inflammatory Bowel Disease & Root Cause Gut Health with Dr. Brian Jerby

Tue, 08 Nov 2022 11:00:00 +0000

As a colorectal surgeon, Dr. Brian Jerby has spent years dealing with the end-stages of GI diseases such as Crohn’s Disease and Ulcerative Colitis. He now focuses on getting to the root causes for preventing surgical intervention and mitigating long-term medication use. As a functional medicine certified practitioner, Dr. Jerby employs personalized tools to treat these patients such as nutrition, the microbiome, hormonal balance, lifestyle modification, and more – with excellent results.

In today’s episode, we finally hit the topic of inflammatory bowel disease and the functional approach needed to treat these complex diseases. Dr. Jerby also discusses the critical role of stool testing in his practice and his excitement regarding the clinical implications of new metagenomic sequencing technology.

Today on The Lab Report:

2:45 Meet Dr. Brian Jerby and hear his journey to functional medicine
8:10 Where do we start with Inflammatory Bowel Disease?
14:00 Is there hope for patients with IBD?
16:25 Diet and IBD
20:00 Patient success stories using stool profiles
24:55 Whole-genome sequencing in clinical practice
29:35 The latest on fecal transplants
35:55 Work with Dr. Brian Jerby and his practice
40:45 The Fireball

Additional Resources:

Legacy Health

The Gut Connection Podcast

Root + Ritual Functional Medicine

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Rachel Martin - GO WITH YOUR GUT

Tue, 01 Nov 2022 10:00:00 +0000

In functional and precision medicine, we know the importance of a healthy microbiome as it relates to overall health and wellness. Translating this into clinical practice is an art. Rachel Martin, a functional medicine nurse practitioner, specializes in gut health but through a different lens. Her approach to teaching and healing offers a fresh perspective with profound ramifications. What if we focus on stress and mental health first to optimize the microbiome for systemic health?

In today’s episode Rachel Martin discusses her unique program “Go With Your Gut.” She talks about the importance of the gut-brain axis, building community, mitigating stress, and why this should be the first line of treatment for gut health.

Today on The Lab Report:

3:40 Rachel Martin on her journey to functional medicine
8:10 Addressing stress and the gut-brain axis first
11:40 Systemic effects of the microbiome
14:30 Rachel’s “Go With Your Gut” program
17:45 Stress management strategies
21:10 Functional medicine testing in practice
25:40 Re-framing society’s expectations
30:00 The Fireball

Additional Resources:

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Shedding Some Light on Seasonal Affective Disorder [Rebroadcast]

Tue, 25 Oct 2022 10:00:00 +0000

Our bodies contain an inner clock that helps to regulate hormones and biochemistry. This clock is referred to as the circadian rhythm. The fine timing of this biological rhythm requires signaling from light. With the change in seasons, many of us feel the systemic effects of less daylight in various ways, one of which is altered mood. Seasonal Affective Disorder (SAD) is a type of depression that correlates with seasonal patterns.

In today’s episode, we discuss the biochemistry of how light regulates the circadian rhythm, the etiologies of seasonal affective disorder, and various treatment strategies which have been used to improve symptoms.

Today on The Lab Report:

2:15 The circadian rhythm and chronobiology – defining terms
5:00 Light signals and hormonal regulation of the biological clock
7:25 Health implications of seasonal change
9:30 Seasonal Affective Disorder
13:45 Vitamin D – What does it do?
18:10 Therapeutics and interventions
21:00 Question of the Day:
- Can seasonal affective disorder happen in the summer?

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The Real Deal with Akkermansia

Tue, 18 Oct 2022 10:00:00 +0000

With the advent of the Human Microbiome Project and advancing technologies in whole-genome sequencing, the critical role of the gastrointestinal microbiome becomes clearer and clearer. We know the microbiome helps extract nutrients from the diet, creates important systemic metabolites, communicates with our skin and brain, and so much more. That being said, one such bacteria continues to stand out in the crowd– Akkermansia muciniphila. This bacterium, or lack thereof, may be a key player in obesity, metabolic disorders, inflammatory bowel disease, and ‘leaky gut’.

In today’s episode, we explain the vital role of Akkermansia muciniphila. We discuss dietary strategies to boost levels and the new Akkermansia probiotic supplement!

Today on The Lab Report:

2:30 The mucus layer of the GI tract
6:00 Mucin vs. mucus and altering the mucus layer
7:35 Akkermansia muciniphila
11:55 Logical Speculation – High levels good or bad?
14:10 Clinical implications of low levels of Akkermansia
16:40 Strategies to boost Akkermansia
18:05 Finally! A new Akkermansia probiotic!
19:05 Berberine is kinda awesome
20:00 Question of the Day
- How does Genova evaluate Akkermansia and mucin?

Additional Resources:

Pendulum Life (Use Promo Code GENOVA for 20% off your first month of a Pendulum membership!)

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Patti & Michael Break Down Biofilms [Rebroadcast]

Tue, 11 Oct 2022 10:00:00 +0000

Bacteria are everywhere in the environment. Although we understand there is a delicate balance of bacteria in our bodies which keep us healthy, many don’t grasp the complexity of how bacterial populations interact, adapt, and survive. They form structures called ‘biofilms’ which have become a hot topic in functional medicine as it relates to treating resistant or recurrent infections.

In today’s episode, we dive into the topic of bacterial biofilms- when to suspect them and ways to treat them.

Today on The Lab Report:

4:00 What are biofilms?
6:05 EPS, persister cells, and quorum sensing
8:40 Clinical importance and redeeming qualities?
11:35 Treating biofilms
13:20 Antimicrobial lipids
14:55 “What is it?”
18:50 Biofilm take-home points

Additional Resources:

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Dr. Anna Lembke - The Dopamine Hit and Addiction

Tue, 04 Oct 2022 10:00:00 +0000

In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways.

Today on The Lab Report:

3:00 Anna Lembke explains dopamine and the reward system
6:05 Dopamine hits in today’s society
10:40 Moderation vs. Abstinence
13:30 Social media and children
15:00 Does society award addictive behavior?
18:45 Long term dopamine dysfunction and Parkinson’s disease
22:00 Parenting in the digital age
27:20 The Fireball

Additional Resources:

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Microbiome Diversity

Tue, 27 Sep 2022 10:00:00 +0000

In today’s episode, we discuss the industry standard Shannon Diversity Index as measured on Genova’s brand new Microbiomix profile.

Today on The Lab Report:

3:15 Better Know a Biomarker: Shannon Diversity Index
6:00 Evenness and Richness
7:30 Alpha vs. beta diversity
10:05 Who’s Claude Shannon?
13:00 Get Outta Here!
15:50 Simpson vs. Shannon Index
17:40 The numerical score
19:45 Improving the diversity score

Additional Resources:

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Vitamins and the Microbiome

Tue, 20 Sep 2022 10:00:00 +0000

In the evolving landscape of microbiome research, we are beginning to see that our gut microbiome has more control over our health than we ever knew. Genova’s Microbiomix profile uses the newest technology of whole genome sequencing which adds another layer of understanding. We now see that the microbiome is one of our most important health indicators. We know that commensal bacteria produce many metabolites with far-reaching effects. But many of us forget that these bacteria also produce vitamins.

In today’s episode, we discuss vitamin production in the GI tract, its contribution to systemic levels, and the interesting interplay between microbial communities.

Today on The Lab Report:

4:30 Commensal bacteria make vitamins!
9:15 Colonic absorption, SIBO, and nutrient competition
11:35 Michael Writes Report Commentary
13:55 Microbial Vitamin K
16:05 How much do microbial vitamins contribute to DRI?
18:10 Which bacteria make what?
19:10 Microbiomix- Leading the Evolution of Microbiome Assessments
20:05 Question of the Day:
- Which ‘vitamer’ forms are made in the gut?

Additional Resources:

Comprehensive Thyroid Assessment

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Thyroid Nutrients [Rebroadcast]

Tue, 13 Sep 2022 10:00:00 +0000

The thyroid gland is responsible for regulating metabolism and is sometimes referred to as the ‘thermostat’ of our bodies. Even minor abnormalities in thyroid function can have far-reaching effects for every organ system. Thyroid diseases are prevalent worldwide and thyroid hormone replacement therapy is common. But many don’t realize that there are basic dietary nutrients that can have a huge impact and help optimize thyroid function.

In today’s episode, we recap thyroid physiology and discuss how nutrition underpins thyroid hormone synthesis and metabolism.

Today on The Lab Report:

4:00 Recap of basic thyroid gland physiology
7:45 Iodine and types of salt
10:45 Selenium, selenoproteins, and orbital rings
13:15 Everyone’s favorite cofactor - zinc
14:45 Iron and heme-dependent enzymes
16:10 Protein and amino acids
17:30 Question of the Day:
- Why does the NutrEval measure these nutrients in different matrices?

Additional Resources:

NutrEval

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Mast Cell Activation Syndrome & Histamine

Tue, 30 Aug 2022 10:00:00 +0000

Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyper-reactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused.

Today on The Lab Report:

3:05 Mast Cell Activation Diseases
5:15 What is a mast cell? Why do we care?
7:05 Symptoms of histamine release
8:40 Histamine intolerance vs. MCAS
11:11 Foods: High Histamine or Low Histamine?
14:25 Non-food related histamine associations
15:30 Diagnosing and treating MCAS
18:00 Question of the Day
- - What Genova profiles can help parse out histamine intolerance v. MCAS?

Additional Resources:

IgE Food Antibodies Profile

IgE Inhalants - Allergy Profile

IgE Mold - Allergy Profile

Supporting Immune Function

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Dr. Dom D'Agostino and the Biochemistry of Ketosis [Rebroadcast]

Tue, 23 Aug 2022 10:00:00 +0000

Dr. Dominic D’Agostino is a well-known leading researcher who studies nutritional strategies and metabolic-based therapies in neurological disorders, seizures, cancer, and metabolic wellness. He also happens to be a preeminent voice and proponent of the ketogenic diet. Ketosis is your body’s ability to burn fat for fuel when carbohydrates are not readily available – producing ketones. No longer thought of as a fad diet, it is actually a metabolic state that many adopt as a lifestyle given the emerging health benefits it confers. The metabolic effects of ketosis are vast and new insights are evolving rapidly.

In today’s episode, we dive deep into biochemistry and metabolism with Dr. D’Agostino. He explains the latest research advancements in ketosis, differences between endogenous and exogenous ketones, and how continuous glucose monitoring factors into ketosis and metabolic health measures.

Today on The Lab Report:

4:00 Welcome back, Dr. D’Agostino – why he chooses to study ketosis?
6:50 Surprising new clinical applications of ketogenic diets
12:40 Alzheimer’s disease, type 3 Diabetes, and ketones
17:00 Exogenous ketone esters/salts vs. endogenous ketones and metabolic effects
26:30 Is there a role for the ketogenic diet in ADD/ADHD?
29:15 Continuous glucose monitoring and ketosis
34:35 Glucose/ketone variation and the calculated index
43:00 Metabolic Health Summit
46:40 The Fireball

Additional Resources:

KetoNutrition

Metabolic Health Summit

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Healthy Gut, Happy Life with Taylor Dukes

Tue, 09 Aug 2022 10:00:00 +0000

Taylor Dukes is a board-certified family nurse practitioner with a very unique voice in functional medicine. Her practice is comprised of so many different kinds of patients. She specializes in family medicine, fertility, peri- and postnatal care, but also treats many high-performance athletes and celebrities. One of Taylor’s many passions is the role of the microbiome in systemic health – which applies to all patient populations. Her approach to optimizing gut health is comprehensive and her results speak for themselves.

Today, Taylor is back on The Lab Report to chat about the role of the microbiome in health and disease, and she gives us her practical tips on optimizing it.

Today on The Lab Report:

3:45 Taylor Dukes is back – and busier than ever!
8:30 The microbiome, sleep, and the gut-brain connection
11:15 Gut-skin axis – acne and eczema
13:15 Hormonal balance and the estrobolome
17:25 High performance athletes and the microbiome
20:22 Taylor’s approach to optimizing the gut
22:20 Peri- and postnatal nutrients
24:00 The Fireball

Additional Resources:

Taylor Dukes Wellness

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Supporting Immune Function with Dr. Tom Guilliams

Tue, 02 Aug 2022 10:00:00 +0000

If there’s one thing we’ve all come to appreciate during the COVID-19 pandemic, it is the importance of a healthy immune system. The immune system is a complex network of various cells, proteins, and organs that work together to help your body recognize and mitigate potential invaders, as well as recognize and protect itself. Metabolic health, proper nutrition, a healthy microbiome, and intact gut barrier are all important components necessary to support immune function.

Dr. Tom Guilliams is a PhD researcher with a specialty in molecular immunology. He recently updated his seminal work “Supporting Immune Function.” Tom joins us on today’s show to discuss innate and adaptive immunity and outline the functional medicine approach to optimize immunity.

Today on The Lab Report:

3:45 Tom Guilliams is back!
5:25 Conversations about immune health during the pandemic
9:15 Metabolic reserve
13:20 Literature during the COVID-19 pandemic
16:40 Immunosenescence
21:20 Functional approach to immune health
26:25 Nutrition and immunity
33:00 The role of the gut in immune health, innate vs. adaptive immunity, and vaccines
45:40 Emerging research on the effect of COVID on the microbiome
52:15 The Fireball

Additional Resources:

Point Institute

Lifestyle Matrix Resource Center

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If you’re a patient looking for a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect.

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Tick-Borne Illnesses

Tue, 19 Jul 2022 10:00:00 +0000

Summer brings tons of outdoor activities like hiking, camping, and backyard barbeques. It also brings bugs and insects. Likely you’ve encountered your fair share of bug bites, but one bite you don’t want to ignore is a tick bite! Because ticks are visually easy to miss, tick bites can go unnoticed too. Ticks can transmit organisms into your systemic circulation resulting in acute and chronic symptoms. Not all tick bites cause illness, but when they do it can be serious.

In this episode, we touch on some common tick-borne illnesses, what symptoms to look for, and how to treat them.

Today on The Lab Report:

2:45 Ticks are gross
6:15 Rocky Mountain Spotted Fever
8:45 Babesiosis
11:30 Lyme disease and conspiracy theories?
13:10 Deer ticks, rashes, and spirochetes
14:20 Chronic Lyme disease controversies
16:00 Nuances in Lyme Disease testing
18:00 Pathophysiology and treatment of chronic Lyme

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Coffee Talk

Tue, 12 Jul 2022 10:00:00 +0000

Many of us start the day with a hot cup of coffee. It’s not only a delicious beverage, but coffee is also part of our collective social fabric. Some drink it mainly for the caffeine and stimulating effect without realizing some of the important health benefits to coffee. However, like all things, moderation is the key. Too much caffeine leaves many people feeling jittery and anxious and at times, this can be dangerous. But coffee is more than just caffeine. Other compounds within it have important influences on our health.

In today’s episode, we discuss the constituents of coffee and coffee beans and the mechanisms by which they affect health and disease.

Today on The Lab Report:

2:40 The basics of coffee
5:45 Caffeine – the good, the bad, and the ugly
11:30 Diterpenes (kahweol and cafestol)
14:00 Chlorogenic acids and antioxidants
14:55 Micronutrients, adding cream and sugar
17:00 Health benefits and risks – what does the literature say?
23:40 Question of the Day
- How does caffeine affect cortisol testing?

Additional Resources:

Intestinal Permeability Assessment

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Arnica - Is it a Real Thing?

Tue, 05 Jul 2022 10:00:00 +0000

Of all the herbal and homeopathic natural therapies available, Arnica has become the most recognized in popular culture and the conventional medicine landscape. Many swear by its ability to reduce swelling, bruising, and inflammation. It can be found in over-the-counter gels, creams, and sometimes tinctures. Literature and outcome studies using Arnica cream are sparse, yet anecdotally there have been some interesting results. So, does it really work? And if so, how?

In today’s episode, we discuss the herb Arnica and its medicinal constituents. We break down the proposed mechanisms of action, benefits and potential dangers, and even touch on homeopathic dilutions.

Today on The Lab Report:

4:00 Introducing the Arnica plant
6:15 Medicinal plant constituents and physiologic effects
9:15 Preparations – poultices, tinctures, and cream/gel
11:15 Break it down – Homeopathy and dilutions
15:50 Toxicities and dangers of mis-using Arnica
19:35 What’s in a name?

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LPS and Gut Bacteria!

Tue, 21 Jun 2022 10:00:00 +0000

In general, we often think about the commensal bacteria as being beneficial to your health. Did you know that the bacteria in the gut microbiome can also contribute to systemic inflammation and disease? There is molecule called lipopolysaccharide (LPS) within the outer membrane of all gram-negative bacteria. LPS can be readily taken up into circulation where it acts as an inflammatory trigger (endotoxin). But not all LPS can trigger the immune system. Only LPS molecules with a structure containing at least six acyl groups are large enough to stimulate cytokine release – hexa-acylated LPS.

On today’s episode, we discuss the LPS molecule, and more specifically hexa-LPS. What is it, how does it cause a problem, and more importantly, what can we do to prevent it from causing inflammation?

Today on The Lab Report:

2:30 Gram-negative vs gram-positive bacteria
4:40 Lipopolysaccharide (LPS) and systemic endotoxemia
7:05 Hexa-acylated LPS vs. LPS
9:55 Protecting the gut mucosal barrier
10:40 The role of dietary fat
12:15 Logical Speculation: Dietary saturated fats are not all created equally
17:15 Question of the Day?
- How do we measure LPS?

Additional Resources:

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Milk? (Patti & Michael on the A1 vs A2 Debate)

Tue, 14 Jun 2022 10:00:00 +0000

Many patients are not able to tolerate milk and dairy products due to GI symptoms such as bloating or diarrhea. In functional medicine, an elimination diet or food antibody testing can help uncover if the casein in cow’s milk might be at the root of these symptoms. Patients often turn to milk alternatives such as plant and nut ‘milk’ to avoid the difficulties with cow’s milk. However, research is showing that it may be a specific type of casein that is causing the problem in milk and there is a debate on the health risks of types of casein: A1 vs. A2.

Today we break down the controversy regarding A1 versus A2 milk and we discuss the pros and cons of various types of milk.

Today on The Lab Report:

2:10 Not all white liquid is milk!!!
4:15 Milk constituents
7:15 Casein – A1 vs A2 beta-casein and BCM7
9:10 BCM7 and systemic illnesses
10:55 Which animals give us A1 or A2 milk?
13:25 Controversies in literature – other factors
14:30 Game alert: “What is it?”
17:00 Benefits and concerns with plant and nut ‘milks’

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Red Meat & Heart Disease

Tue, 07 Jun 2022 10:00:00 +0000

Today we discuss TMA and how it becomes a cardiovascular risk factor (TMAO). We tell you about TMA’s many sources - besides red meat - and why you should care.

Today on The Lab Report:

2:10 Food controversies
3:50 Break it Down: Trimethylamine (TMA) and trimethylamine N-oxide (TMAO)
6:40 TMAO, carnitine, and choline
10:00 Wait, which foods are actually the problem?
13:50 Red meat, TMAO, and cardiovascular risk
18:40 Dietary microbiome changes
20:05 Question of the Day:
- Which Genova profiles can help?

Additional Resources:

Gillett Health on YouTube

Cardio Check

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Addressing Pill Fatigue with Justin DeTurris

Tue, 31 May 2022 10:00:00 +0000

Many clinicians in functional medicine advocate diet and lifestyle‐first approaches to optimizing health. Though in spite of best efforts there is often still a need for nutraceutical supplements - and targeted supplementation can be a game-changer in some cases. However, the issue of compliance and ‘pill fatigue' becomes a real challenge when patients are overwhelmed with 5-10 supplements at once. Justin DeTurris helps to solve this problem. He co-founded Personalized Nutrients which allows practitioners to consolidate multiple nutraceutical products into one homogenous formulation giving them absolute control in individualizing therapies for their patients.

Today, we talk to Justin DeTurris about standards within the nutraceutical supplement industry, the challenge of compliance and pill fatigue, and what you can do about it.

Today on The Lab Report:

3:50 Meet Justin DeTurris and Personalized Nutrients
8:55 Questions you should be asking about standards and raw materials
14:30 Fillers, purity, and supply chain challenges
20:25 ‘Pill Fatigue’ and patient compliance
28:50 Personalized Nutrients’ -Online Formulator
31:45 The Fireball

Additional Resources:

Freedom to Formulate

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Balancing Men's Hormones with Dr. Kyle Gillett

Tue, 24 May 2022 10:00:00 +0000

Dr. Kyle Gillett has a unique approach to patient care using his six pillars of health: exercise, diet, sleep, stress, sunshine, and spirit. His expertise and teaching style are highly regarded in the integrative and functional medicine industry. Dr. Gillet continues to make a name for himself in national media by forwarding the concepts of personalized medicine. Although he is an expert in many fields, in this episode we focus on male hormones.

Listen in as we discuss Dr. Gillett’s pillars of health and how he uses them in practice. We also hear about his approach to balancing male hormones, the role of testing, and when to use testosterone replacement therapy (TRT).

Today on The Lab Report:

3:20 Kyle Gillett on family medicine and obesity medicine
8:00 The 6 Pillars of Health
10:45 The overall approach to male hormonal balance
12:20 When to reach for Testosterone Replacement Therapy (TRT)
19:35 Aromatase inhibitors and estrogen
22:05 TRT in females
24:35 The roll of the microbiome in hormonal health
28:40 Important nutrients for hormones
30:30 The Fireball

Additional Resources:

Gillett Health

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Health Optimization Medicine with Dr. Scott Sherr

Tue, 17 May 2022 10:00:00 +0000

Many functional and integrative clinicians practice medicine through the construct of finding the root cause of chronic complaints and disease management. What if there was a framework in place to help clinicians navigate a focus on health optimization? Dr. Scott Sherr has the answer. Along with Dr. Ted Achacoso, he founded Health Optimization Medicine and Practice (HOMe/HOPe), a non-profit education company offering CME accredited certification and ongoing educational modules to help clinicians detect and correct root causes of health – not disease.

Today we discuss this paradigm shift with Dr. Scott Sherr and learn about the HOMe/HOPe philosophy. We also dive into hyperbaric oxygen therapy, one of Dr. Scott’s many specialties.

Today on The Lab Report:

3:20 Meet Dr. Scott Sherr and hear about his path to HOMe
12:45 Competing paradigms and creating a new framework
16:50 The HOMe/HOPe approach – ‘saluneotinoholobiontology’
22:35 Education and Practice Modules
26:20 Hyperbaric oxygen therapy
40:00 Lab testing in the HOMe/HOPe framework
49:25 The Fireball

Additional Resources:

HOMe/HOPe

Dr. Scott Sherr - HBOT

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Josiah Bartz: Solutions for Your Busy Practice

Tue, 03 May 2022 10:00:00 +0000

Many clinicians who are new to functional medicine have a difficult time translating these concepts into their clinical practices. That transition from conventional to personalized medicine can feel overwhelming - but the Lifestyle Matrix Resource Center has the answers! Josiah Bartz oversees this company and is dedicated to helping healthcare professionals implement lifestyle-based therapies in their practices.

Today, we meet Josiah Bartz to discuss the challenges faced by clinicians and the numerous, innovative ways Lifestyle Matrix Resource Center can help!

Today on The Lab Report:

3:55 Josiah Bartz - 20 years of watching functional medicine evolve
15:30 What is the Lifestyle Matrix Resource Center?
24:20 Practical tools to help clinicians
31:40 New membership-level resources
39:45 The Fireball

Additional Resources:

Lifestyle Matrix Resource Center

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Dr. Jade Teta - Where Meaning Meets Metabolism [Rebroadcast]

Tue, 26 Apr 2022 10:00:00 +0000

In functional medicine, we dig deeper to find the root cause of illness and strive to find personalized strategies to optimize health. However, sometimes even that falls short. Dr. Jade Teta has spent over 20 years treating patients, teaching, and writing about health and wellness. He blends biochemistry and philosophy in a way that inspires us to find our true purpose. In so doing, we can all learn how to become “Next Level Human.”

In today’s episode, we discuss Dr. Teta’s unique approach to health, diet, metabolism – and philosophy!

Today on The Lab Report:

3:25 Meet Dr. Jade Teta and learn his definition of a Next Level Human
9:25 Integrative endocrinology – a holistic approach to metabolism
12:55 The “Do What Works for You” Diet and the language of metabolism
20:15 Translating diet, lifestyle, and metabolism to patients
24:20 Wearable devices
27:00 ‘Meathead Philosopher’
31:05 The Lack of Purpose pandemic
39:30 Teta’s online teaching programs
42:50 The Fireball

Additional Resources:

jadeteta.com

Next Level Human Podcast

Human 365

Next Level Tribe

The Metabolic Effect Diet

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Dr. Taylor Sittler: Levels of Metabolic Resiliency

Tue, 19 Apr 2022 10:00:00 +0000

The metabolic health crisis continues to grow. In the midst of the COVID-19 pandemic, this became even more obvious as it relates to patients’ poor outcomes and lack of resiliency. Dr. Taylor Sittler is the Head of Research at Levels Health, an industry leader in continuous glucose monitoring. His work at Levels aims to help people take control of their diet and lifestyle to improve metabolic resiliency and optimize their health.

Today, we talk to Taylor about the origins of this mounting crisis of metabolic dysfunction, his thoughts on the best ways to measure it, and what we can do to improve our resiliency.

Today on The Lab Report:

3:15 Taylor Sittler and his path to Levels
7:30 Origins and scope of the metabolic health crisis
15:45 Cortisol and COVID
17:30 What is metabolic resiliency?
21:45 Measuring metabolism
25:15 Fat vs. Muscle-centric theories of metabolic dysfunction
28:15 What can we do to improve our resiliency?
33:30 CGM and how Levels is optimizing health
41:45 The Fireball

Additional Resources:

Levels

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Metabolic Detoxification with Dr. Sheila Dean

Tue, 12 Apr 2022 10:00:00 +0000

In today’s episode, we dive into one of Dr. Dean’s keen interests – metabolic detoxification. We discuss the physiologic process of detoxifying xenobiotics and hormones and why nutrition, genomics, and the microbiome are vital.

Today on The Lab Report:

3:00 Meet Dr. Sheila Dean and hear about her path to functional medicine
9:15 Toxins, Detox, and Biotransformation
13:15 Phase I and Phase II pathways
16:35 Nutrition, genetic SNPs, and detoxifying hormones
24:45 Clinical strategies for optimizing key detox pathways
31:00 All about IFNA
33:40 The Fireball

Additional Resources:

Integrative and Functional Nutrition Academy

DetoxiGenomics

Essential Estrogens

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Patti & Michael "Air" it Out

Tue, 05 Apr 2022 10:00:00 +0000

Your smartphone weather app likely includes insight into the “Air Quality Index”. But what does it mean and why should you care? We don’t often stop to take into consideration the quality of the air we breathe. Environmental toxins are everywhere – food, water, soil, and yes, air. Not only can toxins in the air directly affect your lungs, but there are also long-term systemic health effects that may be less obvious.

In today’s episode, we talk about indoor and outdoor ‘air quality,' the connection to chronic disease, and ways to mitigate potential damage.

Today on The Lab Report:

4:00 Outdoor air and the Air Quality Index
8:00 Indoor pollutants
9:20 Off-gassing and ventilation
14:30 Health effects of air toxins
19:00 Air filters and purifiers
23:30 House plants to the rescue!

Additional Resources:

Environmental Health Perspectives

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This Episode is NEAT!

Mon, 28 Mar 2022 10:00:00 +0000

Burning extra calories doesn’t have to mean hardcore exercise. Your body uses energy all day long just breathing, digesting food, toe-tapping, and standing. This basic movement is called ‘non-exercise activity thermogenesis’ and at the end of the day can add up to tremendous energy expenditure. But just how much? Can we maximize it for long-term weight management? Are we eating enough calories in the day to compensate?

In today’s episode, we discuss this NEAT concept – non-exercise activity thermogenesis. We talk about metabolic energy, movement, and caloric balance.

Today on The Lab Report:

3:30 Energy, metabolism, and basal metabolic rate
5:30 How many calories does it take to keep the lights on?
7:30 Non-exercise activity thermogenesis (NEAT) vs. exercise
16:35 A NEAT game
20:05 The thermic effect of food
21:55 Question of the Day
- Can you fidget your way into a calorie deficit for weight loss?

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Mmmmmm...Chocolate!

Tue, 22 Mar 2022 10:00:00 +0000

We can all agree that chocolate is delicious. Is it possible that it’s also healthy for us? How many of us stop to consider that it comes from a tree? What is it about that tree and its seeds that can benefit our health? With all that sugar, is chocolate good or bad for us?

Today we discuss where chocolate comes from, the difference between white/dark/milk chocolate, and some interesting health benefits.

Today on The Lab Report:

3:00 Why are we talking about chocolate?
4:30 From tree to candy bar – a chocolate flow chart
8:00 History of the ‘Food of the Gods’
10:00 White chocolate and the bitter butter battle
13:30 Health benefits of dark chocolate
15:00 Kitchen Cook-cophany!

Additional Resources:

Keto Chocolate Chip Cookies

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Dr. Dom D'Agostino and the Biochemistry of Ketosis

Tue, 15 Mar 2022 10:00:00 +0000

Today on The Lab Report:

4:00 Welcome back, Dr. D’Agostino – why he chooses to study ketosis?
6:50 Surprising new clinical applications of ketogenic diets
12:40 Alzheimer’s disease, type 3 Diabetes, and ketones
17:00 Exogenous ketone esters/salts vs. endogenous ketones and metabolic effects
26:30 Is there a role for the ketogenic diet in ADD/ADHD?
29:15 Continuous glucose monitoring and ketosis
34:35 Glucose/ketone variation and the calculated index
43:00 Metabolic Health Summit
46:40 The Fireball

Additional Resources:

KetoNutrition

Metabolic Health Summit

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The Fertility Fix with Dr. Jaclyn Smeaton

Tue, 08 Mar 2022 11:00:00 +0000

Dr. Jaclyn Chasse-Smeaton is an international teacher and lecturer who is considered a preeminent expert in integrative and functional medicine approaches to infertility. As a naturopathic physician, she has helped hundreds and hundreds of couples conceive- even in cases that seemed hopeless - through her private practice and mentorship programs.

In today’s episode, Dr. Smeaton outlines her approach using root cause medicine and uncovers factors that are often overlooked when it comes to infertility. We discuss diet, nutrition, the gastrointestinal microbiome, exercise, and stress management – and why they matter when it comes to fertility.

Today on The Lab Report:

3:30 Meet Dr. Jaclyn Smeaton and hear why she focuses on women’s health
7:15 Lack of options for women hormone imbalances and infertility gender bias
13:30 The microbiome and fertility
15:30 Nutrition optimization in preconception and maintaining a pregnancy
17:15 Using functional medicine testing in fertility
19:10 Debunking exercise myths in pregnancy
20:45 HPA axis balance in motherhood and fertility
22:30 Emerson Ecologics and Wellevate
25:10 The Fireball

Additional Resources:

Hello Fertility

Emerson Ecologics

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Dr. Pam Smith & the Art of Hormone Replacement

Tue, 22 Feb 2022 11:00:00 +0000

Dr. Pam Smith is one of the most revered teachers and mentors in integrative medicine. After years of practicing emergency medicine, then decades as an Anti-Aging/Metabolic Medicine specialist, Dr. Smith is a go-to resource for many new clinicians. She’s written several books on a variety of precision medicine topics though is widely known for her work in hormone balance and bioidentical hormone replacement therapy (BHRT).

Today, we dive into hormone balance with Dr. Pam Smith. She offers her insight into various types of BHRT, testing options and pitfalls, and we preview her upcoming book “What You Must Know About Women’s Hormones (2nd edition)”.

Today on The Lab Report:

5:55 Meet Dr. Pamela Smith and hear her thoughts on the evolution of precision medicine
9:55 Hormone balance, systemic effects, and when to start BHRT
12:35 Bioidentical vs. synthetic hormones
13:40 Compounding pharmacies, bases, and delivery systems
16:30 When to use various hormone testing types
19:55 Detoxification and methylation
21:45 Spurious testing results – Where to start? Timing of dosage? Exogenous exposure?
25:15 What You Must Know About Women’s Hormones & the soon to be released 2nd edition
27:00 The Fireball

Additional Resources:

Center for Precision Medicine

Complete Hormones

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Fatty Acids & Inflammation

Tue, 15 Feb 2022 11:00:00 +0000

In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’

Today on The Lab Report:

3:20 What are eicosanoids?
6:05 Fatty acids and the inflammatory cascade
9:10 Lipoxygenase (LOX) and cyclooxygenase (COX)
10:00 The COX eicosanoids – prostanoids and thromboxane
12:10 Leukotrienes, lipoxins, resolvins, and LOX
13:15 Aspirin, fish oil, and heart disease
16:30 Question of the Day
- How should we measure fatty acids?

Additional Resources:

Essential & Metabolic Fatty Acids - Bloodspot

The omega-3 index as a risk factor for coronary heart disease

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Dr. Christian Jenski – A Masterclass in Applying Functional Medicine

Tue, 08 Feb 2022 11:00:00 +0000

Dr. Christian Jenski is a conventionally trained emergency room physician who has made the huge leap to functional and precision medicine. Many of you will remember him from a prior episode where we discussed the clinical application of functional medicine testing and he offered his real-world examples and testimonials showcasing the power of root-cause medicine. Due to overwhelming feedback from listeners, both clinicians and patients alike, Dr. Jenski is back!

Today we focus on the core principle that ‘all disease begins in the gut.’ Dr. Jenski discusses the way GI abnormalities can underlie many, if not all, chronic health conditions, what to look for on a stool test, and why you should care.

Today on The Lab Report:

3:40 Christian Jenski is back!
5:30 ‘IBS’ stool testing patterns
8:05 The gut and systemic disease
13:25 Wow! moments – when in doubt, heal the gut!
14:45 Treating dysbiosis – supplements, diet, and more
17:40 Hormonal imbalances and the GI tract
21:50 Elimination diets and food sensitivities/allergies
29:00 The Fireball

Additional Resources:

Richmond Integrative & Functional Medicine

Comprehensive Thyroid Assessment

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Thyroid Nutrients

Tue, 18 Jan 2022 11:00:00 +0000

The thyroid gland is responsible for regulating metabolism and is sometimes referred to as the ‘thermostat’ of our bodies. Even minor abnormalities in thyroid function can have far-reaching effects on every organ system. Thyroid diseases are prevalent worldwide and thyroid hormone replacement therapy is common. But many don’t realize that there are basic dietary nutrients that can have a huge impact and help optimize thyroid function.

In today’s episode, we recap thyroid physiology and discuss how nutrition underpins thyroid hormone synthesis and metabolism.

Today on The Lab Report:

4:00 Recap of basic thyroid gland physiology
7:45 Iodine and types of salt
10:45 Selenium, selenoproteins, and orbital rings
13:15 Everyone’s favorite cofactor - zinc
14:45 Iron and heme-dependent enzymes
16:10 Protein and amino acids
17:30 Question of the Day:
- Why does the NutrEval measure these nutrients in different matrices?

Additional Resources:

NutrEval

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The Pitfalls of Medical Jargon

Tue, 11 Jan 2022 11:00:00 +0000

Any clinician who enters the medical profession understands that a large part of the training is learning the lingo and essentially a new language. Even those who have been in practice for quite some time know that new fields of study emerge, and new terms can be borne out of that. Sometimes the medical jargon can get confusing even though what is being discussed is not new.

In today’s episode, we discuss some of the latest terms and how/why their use in clinical practice evolves. We also try to clarify a few concepts that many of us confuse and misuse.

Today on The Lab Report:

3:25 Medical lingo and jargon
4:00 Omics…… and ‘ooooomm’
6:00 Proteomics, genomics, transcriptomics
7:15 Metabolomics and making sense of patterns
11:15 The Jargonomics Game
- British vs. American medical terms
14:30 Causation and correlation
18:20 Question of the Day
- What’s the difference between sensitivity and specificity?

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The Holiday Extravaganza! (Rebroadcast)

Tue, 21 Dec 2021 11:00:00 +0000

We tend to lean on traditions during the holiday season. As they are handed down through the generations, their origins are often forgotten. Not only do traditions offer comfort and help to unify us, but many also have important health benefits.

Today we have some fun with the origins of several holiday traditions and weave in their clinical significance. Make sure to stay tuned for a special Genova version of ‘Twas the Night Before Christmas!

Today on The Lab Report:

2:50 Mistletoe – antioxidants and smoochie smoochie
5:00 Pine, conifers, and evil spirits
7:35 Peppermint candy canes and carminatives
10:35 Checking in with the UK – Oliver’s fear of figgy pudding
14:40 Gingerbread houses made from the super-herb
17:40 Gift-giving and ‘Off the Cuff’ with the Medical Affairs team
24:55 ‘Twas the Night Before Christmas ???????

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Patti & Michael Cover the Electron Transport Chain (Rebroadcast)

Tue, 07 Dec 2021 11:00:00 +0000

Cellular respiration is the process of converting our food into energy to fuel the body. It involves many biochemical reactions to create a molecule called adenosine triphosphate (ATP) - our main energy source. When it comes to ATP production, many of us think about the Krebs Cycle not realizing it is only part of the story. The Electron Transport Chain bears the brunt of the work to keep our cells alive and our bodies functioning optimally.

Although biochemistry can seem challenging, in today’s episode we break it down into simplistic terms and explain why you should care about it. Listen as we discuss the importance of the electron transport chain.

Today on The Lab Report:

2:15 Basic overview of cellular respiration and ATP
4:50 Breaking it down
7:45 The Krebs Cycle and NADH/FADH2
8:30 Electron Transport Chain and the bucket brigade
10:55 ATP Synthase is cool
13:20 High-level recap
14:15 Oxidative stress and CoQ10
17:30 Question of the Day:
- Who is Krebs?

Additional Resources:

ATP Synthase in action

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EPI? Try PERT!

Wed, 01 Dec 2021 11:00:00 +0000

The pancreas is an organ that functions as a gland in the endocrine system by secreting hormones into circulation that help with regulating glucose. However, it also plays an integral role as part of the digestive tract by secreting enzymes to help digest our food. When the digestive functions of the pancreas start to decline what results is Exocrine Pancreatic Insufficiency or EPI. In addition to physical symptoms and digestive complaints, EPI has important clinical implications.

In today’s episode, we discuss exocrine pancreatic insufficiency – causes, clinical associations, diagnosis, and treatment.

Today on The Lab Report:

3:00 The role of the pancreas
5:15 Exocrine vs. endocrine glands
8:20 Exocrine pancreatic insufficiency
10:15 Logical Speculation: SIBO and EPI
13:35 Causes of EPI and signs/symptoms
17:05 Treatment considerations
18:20 Question of the Day?
- Does Genova test for EPI?

Additional Resources:

Stool Testing Support Guide

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The Thanksgiving Episode (Rebroadcast)

Thu, 25 Nov 2021 11:00:00 +0000

Today on The Lab Report:

3:30 Turkey and tryptophan – is it a thing?
5:15 Cranberry sauce apologetics
7:45 Potatoes! - and the microbiome
10:35 Green bean casserole, (fake) mushrooms, and onions
13:15 Hollandaise sauce? Gravy? Stuffing? Ummm…moving on
14:10 Pumpkin is a fruit
15:20 Moderation and modifying your dinner
16:15 Movement and mindfulness
19:20 Gratitude and community – Patti & Michael give thanks

Additional Resources:

Michael's Famous Green Bean Casserole?

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Debunking Diet Myths with Laura Ligos

Tue, 23 Nov 2021 11:00:00 +0000

The one-size-fits-all approach doesn’t work when it comes to diet and nutrition. What works for some may not be right for all. Diet movements like intermittent fasting, the ketogenic diet, and veganism are becoming increasingly popular and widely adopted. Laura Ligos is a registered dietitian and nutritionist who created a platform called “The Sassy Dietitian” which gives people a safe place to learn and ask questions about nutrition. She works to debunk health myths and help people understand the importance of dietary choices for optimal wellness.

In today’s episode, Laura gives her thoughts on changing the diet mindset and discusses some of the pitfalls and concerns related to popular diet trends.

Today on The Lab Report:

3:55 Meet Laura Ligos – the Sassy Dietitian
8:15 Changing the ‘diet’ mindset
10:50 Does everyone need a supplement?
13:40 Pitfalls of the ketogenic diet
16:00 The Game Changers documentary and vegan diets
22:50 Intermittent fasting and restricted eating
27:10 Intuitive eating
30:00 The Fireball

Additional Resources:

The Sassy Dietitian

The Busy Person's Meal Planner

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Kristen Holmes - Optimizing Performance with WHOOP

Tue, 16 Nov 2021 11:00:00 +0000

Wearable devices have become an integral part of sports performance in elite athletes. However, many non-athletes have adopted them as well to optimize sleep, stress, and overall health. WHOOP has been the industry leader in the marketplace while continuing to innovate and promote healthy lifestyle and behavior change. Kristen Holmes is the Vice President of Performance Science at WHOOP. Not only is she an accomplished athlete herself, she’s also a PhD candidate pursuing a doctorate in psychology. Coupling her athletic background with her keen interest in psychology and physiology, Kristen works with WHOOP to offer tangible performance and health data to help anyone transform their lives with positive behavior change, fitness improvements, and injury reduction.

In today’s episode, we talk to Kristen about her definition of optimal performance and how WHOOP can help you achieve it.

Today on The Lab Report:

3:25 Meet Kristen Holmes – from athlete, to coach, to VP of Performance Science
6:45 What is WHOOP and why is it different?
7:55 Heart rate variability for recovery and resilience
11:15 The New WHOOP 4.0 and WHOOP Body
15:00 The impact of sleep deficits – Can Michael sleep ‘harder’?
21:15 Kristen’s definition of Optimal Performance and how can WHOOP help?
30:30 Downside of wearable devices
33:45 The Fireball

Additional Resources:

WHOOP

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Robbie Bent - Breathwork and the Mental Health Revolution

Tue, 09 Nov 2021 11:00:00 +0000

Today’s society has its challenges regarding stress and emotional well-being. We can all agree that mindfulness, community, and better mental health options are needed. Although meditation can be helpful, it can also be intimidating for beginners. Breathwork is a great, simple alternative. Robbie Bent is the co-founder and CEO of Othership – a physical and digital wellness company with structured programs to reduce stress, improve sleep, boost energy, and improve mood using breathwork techniques.

In this episode, Robbie Bent outlines the difference between mediation and breathwork, the health benefits of structured breathing techniques, and even leads us in a breathwork session.

Today on The Lab Report:

3:30 Meet Robbie Bent and hear about his journey to breathwork
10:15 Breathwork and parasympathetic/sympathetic balance
14:20 Mouth vs. nasal breathing and mouth taping
21:10 Differences between mediation and breathwork
24:55 The community at Othership and revolutionizing mental health
31:55 Ice baths, sauna, and emotional resilience
37:00 Robbie leads us in a breathwork session!!!!
- (*Don’t do this while driving)
49:30 Emotional connection and shifting emotional states
53:00 Connect with Robbie and work with Othership
53:45 The Fireball

Additional Resources:

Othership

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Dr. Tom McCoy on Becoming a Vital Human

Tue, 02 Nov 2021 10:00:00 +0000

As a practicing emergency room physician, Dr. Tom McCoy has seen the downstream effects of unhealthy diet and lifestyle choices. While continuing to practice ER medicine, he obtained additional certifications in nutrition and exercise training and is a CrossFit MDL1 medical practitioner. He uses all of this experience and knowledge as part of The Vital Human Project – a coaching program that blends fitness, nutrition, education, and more to help people realize their full human potential.

On today’s episode, Dr. Tom discusses behavioral change, sleep, nutrition, and exercise - and the impact they have on becoming a Vital Human.

Today on The Lab Report:

3:45 McCoy on the short-comings of conventional medicine
7:05 The Vital Human Project
10:30 CrossFit and benefits of HIIT
12:40 The intimidation factor
15:15 Coaching clients for behavior change
17:55 Hunting, respect, and sourcing quality meat
20:55 Impactful lifestyle factors for health
23:00 The Fireball

Additional Resources:

The Vital Human Project

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What is Gluten Anyway?

Wed, 27 Oct 2021 10:00:00 +0000

“Gluten” has become a buzzword in the diet industry and vilified in the court of public opinion – perhaps rightfully so. People are continually looking for gluten-free labels in the grocery store and on restaurant menus trying to be healthier. But why? What is gluten anyway? How does it affect our health? Should no one ever eat gluten again?

In today’s episode, we break down what gluten actually is, what foods contain it, and what happens in the GI tract when we eat it.

Today on The Lab Report:

2:45 What is gluten and why can't we digest it?
7:35 The effects of food manufacturing
9:15 Name that bread!
12:30 Celiac disease vs. gluten sensitivity
17:15 Foods that contain gluten
19:45 Question of the Day
- What can you eat on a gluten-free diet?
21:25 Beware of cross-contamination

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Can you Identify SIBO On A Stool Test? (Rebroadcast)

Tue, 19 Oct 2021 10:00:00 +0000

Small intestinal bacterial overgrowth (SIBO) is a common underlying cause of irritable bowel syndrome (IBS). Bloating, constipation, diarrhea, excessive gas, or nausea are all hallmark SIBO symptoms. When it comes to diagnosis, the gold standard is endoscopic small bowel aspiration. This method is invasive, inconvenient, and not without risk. Breath testing and stool testing are now more commonly used.

Today we dive into some specific patterns seen on stool testing that may point toward a SIBO diagnosis in symptomatic patients.

Today on The Lab Report:

2:50 IBS and bacteria in the small intestine
6:15 Symptoms of SIBO
7:35 Stool testing for IBS
9:05 Commensal abundance
10:00 Digestion and absorption markers
12:30 What do we think we know?
- Pancreatic elastase 1 and SIBO
16:35 Gut metabolites
17:50 Methanobrevibacter smithii and methane dysbiosis
19:50 Bacterial culture
20:50 Question of the Day
- How does methane slow transit time?

Additional Resources:

https://thecommunitycure.com/audiobook

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James Maskell Discusses HealCommunity

Tue, 12 Oct 2021 10:00:00 +0000

Throughout the pandemic many clinicians and patients have learned to adapt and change expectations in their daily lives. Alongside all of those changes, the urgency for optimizing health became apparent. Functional and personalized medicine offers the greatest opportunity to advance how medicine is practiced. As a prominent health economist, James Maskell has been at the forefront of this movement for many years and championing its expansion to make true healthcare available for everyone. Through his many platforms including books, podcasts, international speaking events, and online practice implementation tools, James continues to further the conversation.

In today’s podcast, we catch up with James and re-examine what’s worked throughout the past year and half as functional medicine has evolved as a community. We also discuss his latest venture HealCommunity to support patients and clinicians in behavior change adherence.

Today on The Lab Report:

2:15 Introducing THE James Maskell
4:20 The Power of Community Healthcare
8:50 HealCommunity – Overcoming Obstacles To Community Medicine
17:20 Advantages of Groups – Reinforcement, Support, and Accountability
23:10 Monitoring Outcomes of Community Functional Medicine
25:55 Unforeseen Positives of Telemedicine
31:30 Return to LIVE Functional Forums
40:30 The Fireball

Additional Resources:

Evolution of Medicine

HealCommunity

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Dan Garner - The Science Behind World-Class Results

Tue, 05 Oct 2021 10:00:00 +0000

Elite athletes require physical and mental discipline to optimize their performance. However, adding an understanding of biochemistry and physiology can be a game-changer. Dan Garner specializes in fusing the science of health with the art of coaching for world-class results. Through his company Team Garner Inc., Dan offers high-level personalized training and nutritional coaching for a host of award-winning professional athletes and Hollywood actors. He is a functional medicine clinician, nutrition specialist, strength coach, trainer, lab analyst, best-selling author, and host of The Garner Report podcast.

In today’s episode, Dan Garner debunks some myths and gives some tips regarding supplements, rest and recovery, and diets. Dan’s practical advice can be scaled between elite athletes and anyone wanting to optimize health.

Today on the Lab Report:

4:00 Meet Dan Garner and hear his journey to Team Garner, Inc.
7:45 The myth of adrenal fatigue and interpreting cortisol levels

17:25 Developing a healthy relationship to food and diets
23:00 The psychology of prioritizing health
25:55 ‘Over-rated’ vs. ‘must-have’ supplements
36:40 Rest and recovery for athletic performance
40:10 Wearable devices

42:00 Applying lessons from elite athletes to the general population
46:30 The Fireball

Additional Resources:

CoachGarner.com

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What Are Apolipoproteins?

Tue, 28 Sep 2021 10:00:00 +0000

When assessing risk for cardiovascular disease, most clinicians focus on the concentration of low-density lipoproteins (LDL) also known as ‘bad’ cholesterol, and high-density lipoproteins (HDL) or ‘good’ cholesterol. Though this information is helpful, it’s only part of the picture when it comes to risk. Apolipoproteins are surface proteins found on all cholesterol molecules. They not only contribute to cholesterol structure, but also help to regulate enzymes responsible for lipid metabolism, assist in reverse cholesterol transport, and direct the distribution of fuel throughout the body.

In today’s episode, we discuss apolipoproteins, their function, and why measuring them can be a game-changer when it comes to cardiovascular risk assessment.

Today on The Lab Report:

3:45 What is an Apolipoprotein?
6:40 Particle number and particle size
9:00 Apolipoprotein A-1 and B
11:45 Better Know a Biomarker: Apolipoprotein B/A-1 Ratio
15:30 Lipoprotein (a) - Lp(a)
17:05 Question of the Day?
- What medications/supplements influence the Cardio Check?

Additional Resources:

Cardio Check

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Lipid Ratios - Patti & Michael Talk the New Cardio Check

Tue, 21 Sep 2021 10:00:00 +0000

Many clinicians and patients keep a close eye on cholesterol levels and standard lipid measurements as a way to stratify cardiovascular disease risk. What if there’s more to the story? Genova Diagnostics recently launched a brand-new profile called “Cardio Check.” This profile not only measures conventional lipid levels but also includes cardiometabolic biomarkers and lipid ratios which are being touted in the literature as even more clinically important than lipid levels alone.

In today’s episode, we discuss a few of the lipid ratios included on the Cardio Check and explain why merely targeting LDL (aka the ‘bad cholesterol’) might be missing the mark for cardiovascular health.

Today on The Lab Report:

2:25 THE CARDIO CHECK IS HERE!
5:00 We need cholesterol
6:50 ‘The Lipid Hypothesis’
9:45 Low-density lipoprotein (LDL) and High-density lipoprotein (HDL)
12:00 Total Cholesterol/HDL Ratio
13:50 Triglycerides
15:25 Logical Speculation
17:25 Triglyceride/HDL Ratio
19:05 Question of the Day
- What are the diagnostic criteria for Metabolic Syndrome?

Additional Resources:

Cardio Check

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Dr. Nick Nwabueze - The Fittest Doc

Fri, 17 Sep 2021 10:00:00 +0000

Dr. Nick Nwabueze, aka The Fittest Doc, ‘walks the walk’ when it comes to promoting a healthy lifestyle and teaching patients the importance of diet, exercise, and sleep. As a family medicine physician, he practices online with SteadyMD – a national telemedicine healthcare provider. Dr. Nick has a passion for developing real relationships with his patients to foster lasting changes.

On today’s episode, we talk to Dr. Nick about all things health and wellness and discuss how virtual medicine plays an important role in today’s changing healthcare landscape.

Today on The Lab Report:

3:25 Meet Dr. Nick and hear about his path to medicine
11:00 The importance of sleep!
15:00 Motivating patients to move
19:35 Nutrition for fat loss
23:20 Nick’s personal dietary choices
26:35 Pros and cons of telemedicine
34:35 Work with Dr. Nick
36:30 The Fireball

Additional Resources:

SteadyMD/Dr.Nick

@thefittestdoc

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Dr. Lindsey Mathews on the BIRTHFIT Movement

Fri, 10 Sep 2021 10:00:00 +0000

Pregnancy and childbirth are joyous and miraculous. However, they are also the most physically and emotionally challenging experiences a woman can endure. Dr. Lindsey Mathews created a movement called BIRTHFIT to offer a supportive community for women in motherhood transition and all cycles of life. Strength conditioning, nutritional guidance, emotional support, and educational resources are what make the BIRTHFIT community so popular.

In today’s episode, we meet Dr. Lindsey Mathews and hear about her BIRTHFIT mission. She explains the birthing dream team approach and dispels some myths and misconceptions around pregnancy and postnatal care.

Today on The Lab Report:

4:30 Meet Dr. Lindsey Mathews and hear about her path to chiropractic medicine
7:50 Where did the idea of BIRTHFIT come from?
14:10 It takes a village
19:15 The mountain analogy
21:00 Myths regarding exercise and pregnancy
27:35 Posture and breathwork
34:15 Vaginal birth vs C-section: postnatal care
36:00 Work with BIRTHFIT
36:55 The Fireball

Additional Resources:

BIRTHFIT

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Patti & Michael Discuss The Gut-Brain Axis (Rebroadcast)

Fri, 03 Sep 2021 10:00:00 +0000

Did you know that there is a connection between the brain and the GI tract? This gut-brain axis communicates information in both directions. The commensal bacteria in our gut and their metabolites can directly affect our memory and mood, while our brain can alter bacterial patterns and GI function.

Today we discuss some of the mechanisms by which this axis sends and receives those signals. We also talk about the importance of addressing both when optimizing health.

Today on The Lab Report:

2:30 New Game Alert! Vegetablization of names
4:05 Question of the Day/Fireball:

Since the gut-brain axis is bidirectional, where do you start when it comes to treatment?

6:45 What is the gut-brain axis?
8:10 Communication mechanisms from the GI tract to the brain
13:20 How the brain affects the gut
16:50 Where do you start when it comes to treatment?
18:20 Psychobiotics
20:10 Testing

Additional Resources:

Invictus - William Ernest Henley

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Muscle-centric Medicine with Dr. Gabrielle Lyon (Rebroadcast)

Tue, 31 Aug 2021 10:00:00 +0000

In today’s society, many of us focus on losing fat to achieve and maintain adequate health. But the paradigm is slowly shifting toward the importance of gaining muscle. The metabolic and systemic effects of skeletal muscle are astounding. Dr. Gabrielle Lyon is a functional medicine physician who has pioneered a specialty in “Muscle-centric Medicine”. Years of research and study on the topic have shaped her unique approach to functional medicine and patient care.

In this episode you’ll meet Dr. Gabrielle Lyon and learn about the metabolic influences of building muscle, how it contributes to longevity, and the importance of dietary protein.

Today on The Lab Report:

3:00 Meet Dr. Gabrielle Lyon and hear how her mentor has shaped her career
5:35 Metabolic and anti-inflammatory effects of muscle
9:45 Sarcopenia, insulin resistance, and obesity
11:10 Muscle mass and longevity
14:40 How much dietary protein do we need?
17:00 Animal vs. plant protein and supporting vegan/vegetarian patients
22:20 Red meat, flawed cancer studies, and mTOR
28:00 Lyon’s work with elite military operators
30:45 The Fireball

Additional Resources:

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The Offal Episode

Fri, 27 Aug 2021 14:45:51 +0000

Most of the meat we consume is from the skeletal muscle of animals, which provides a great source of protein in our diet. However, the organs of animals are incredibly nutrient-dense and often overlooked. They are great sources of essential fats, minerals, and vitamins. The common misconception is that organ meat is not palatable. Of course, this depends on which meats and how they are prepared.

In today’s episode, we discuss the important nutrients you might be missing out on if you don’t eat “Offal”.

Today on The Lab Report:

2:05 What is “Offal” eating?
4:25 Skeletal muscle vs. organ meat
7:35 Offal nutrients
10:45 Cautions when eating offal
13:20 Kitchen Cook-cophony!

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Patti & Michael Talk Endothelial Dysfunction

Fri, 20 Aug 2021 10:00:00 +0000

The endothelium is a single layer of cells lining the inside of our blood vessels – and other internal organs. Not only is it responsible for signaling the contraction and dilation of vessels, but it controls clotting, inflammation, oxidative stress, and more! When this system breaks down, its effects are wide-reaching. Endothelial dysfunction is often the root cause of subsequent cardiovascular disease, strokes, and many chronic conditions. Because it can sometimes be reversible, understanding what causes it, how to treat it, and what you can do to prevent it becomes vital.

In today’s episode, we discuss the physiologic role of the endothelium, how it relates to atherosclerosis, and practical strategies to promote cardiovascular health.

Today on The Lab Report:

2:55 Defining Terms – What is the Endothelium?
7:10 Oxidative stress, inflammation, and drivers of endothelial dysfunction
11:00 How do we get to atherosclerosis?
14:20 Indirect causes of endothelial dysfunction
15:50 Direct causes and sheering forces
16:45 Sedentary lifestyle and other triggers
18:00 Movement, omega-3 fatty acids, herbal and prescriptive medications

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James Maskell On Community and the Future of Functional Medicine (Rebroadcast)

Fri, 13 Aug 2021 10:00:00 +0000

Functional medicine has come a long way from being just an “alternative” form of therapy. In recent years, we’ve seen more and more practitioners foregoing what they were taught in medical school to learn how functional medicine works and why many seek it over conventional medicine. What’s in store for the industry in the future? James Maskell joins us to share his predictions.

James is a health economist, serial healthcare founder, and the owner of Evolution of Medicine, a company that helps functional medicine practitioners to start their own virtual practices. He is recognized as a healthcare disruptor, championing innovative ideas that promote prevention and reversal over traditional cures. James is also the host of the Evolution of Medicine podcast, a show featuring experts in the healthcare field that are driving the evolution of modern medicine.

James joins us today to discuss the future of functional medicine. He shares his journey and the events that led him to be part of the functional medicine industry. He describes his clinic management experience, discusses the virtual conferences he hosts, and explains why now is the right time for virtual practitioners to thrive. James also shares why the primary care we receive will need to eventually change.

The future of medicine is communities of people helping each other to get healthy.” - James Maskell

This week on The Lab Report Podcast:

Where his passion for disrupting traditional medicine came from.
How he became part of the functional medicine industry.
His experience in seminar speaking and clinic management.
How he's managing to conduct multiple functional forums all over the world.
What the future of medicine looks like.
Virtual practices and how they're thriving during the pandemic.
Applying lifestyle changes to chronic diseases over drugs.
Why traditional doctors have to unlearn so much to become an expert in functional medicine.
The kind of primary care we have in the United States.

Connect with James Maskell

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Thanks for tuning into this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts, Michael Chapman and Patti Devers. If you enjoyed this episode, please head over to Apple Podcasts to subscribe to the show and give us a rating and review.

Don’t forget to visit our website, like us on Facebook, and follow us on Twitter, Instagram and LinkedIn. Email Patti and Michael with your most pressing questions on functional medicine.

And be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions of Michael Chapman and Patti Devers and their guests.

For medical advice, diagnosis, and/or treatment, please consult a medical professional.

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This Episode is Gluten-Free...Dr. Tom O'Bryan on Autoimmunity

Tue, 10 Aug 2021 10:00:00 +0000

Gluten is a storage protein found in many foods, though mainly wheat, barley, and rye. It is a binder that helps food hold its shape. The human body is incapable of digesting and breaking gluten down. This can cause a host of immune reactions and lead to many chronic health conditions. Unfortunately, the prevalence of Celiac disease, wheat allergies, and non-Celiac gluten sensitivity is on the rise. Dr. Tom O’Bryan is one of the leading experts in functional medicine as it relates to gluten and autoimmunity. His work on wheat-related disorders, environmental toxicity, and autoimmunity is internationally recognized.

In today’s episode, we discuss the devastating impact of gluten, environmental toxins, and autoimmune disease with the expert on these topics, Dr. Tom O’Bryan.

Today on The Lab Report:

3:00 Meet Dr. O’Bryan and hear how aikido shaped his career path
8:50 Immunity vs. autoimmunity and intestinal permeability
21:50 Environmental toxicity and autoimmunity
31:45 Should everyone be gluten-free?
33:10 A balanced microbiome in addition to a gluten-free diet
40:25 Celiac disease, wheat allergy, and non-Celiac gluten sensitivity
46:10 The Gluten Summit
50:50 The Fireball

Additional Resources:

theDr.com

The Gluten Summit

The Autoimmune Fix

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C.J. Martin of CrossFit Invictus

Fri, 06 Aug 2021 10:00:00 +0000

CrossFit is more than high-intensity interval training. It’s a community. C.J. Martin is an athletic coach, and a lawyer, who created Invictus Fitness as a community model to foster emotional support, education, and encouragement. His passion and singular focus have propelled his athletic teams to perennial success at the CrossFit Games and worldwide acclaim. C.J. also helped found a non-profit organization called ‘Kids Helping Kids’ which has raised millions of dollars for neo-natal and pediatric hospital units across the Northwest.

Today, we hear C.J. Martin discuss the power of community and his passion for coaching people to become their best selves.

Today on The Lab Report:

2:45 J. Martin on his journey from lawyer to CrossFit Invictus
8:25 Invictus as inspiration
10:45 2021 CrossFit Games – embodiment of character
13:45 The power of community
17:40 Authenticity
19:36 Getting to the “why” in coaching
22:30 Kids Helping Kids
28:45 The Fireball

Additional Resources:

CrossFit Invictus

Kids Helping Kids

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Unfunc Your Gut with Dr. Peter Kozlowski

Tue, 03 Aug 2021 10:00:00 +0000

Many of us in functional medicine understand the importance of a healthy GI tract to prevent and reverse underlying chronic conditions. Dr. Peter Kozlowski not only practices and teaches these principles to patients, he also wrote a best-selling book called “Unfunc Your Gut” where he explains the interconnection between the gut and systemic health in a simplified, light-hearted, and engaging way.

In this episode, we get Dr. Koz’s take on the gut immune response, dietary influences, and the vital role of mental-emotional-spiritual health.

Today on The Lab Report:

3:00 Meet Dr. Koz and hear his journey to functional medicine
11:15 Dietary changes for big clinical impacts
15:40 Food sensitivity and the GI immune response
18:30 Mental-emotional-spiritual connection to gut health
26:00 Helping patients understand the importance of mental health and the HPA axis
29:20 Intermittent fasting
31:45 How to connect with Dr. Koz
33:10 The clinical impact of the pandemic on GI health
35:30 The Fireball

Additional Resources:

Subscribe, Rate, & Review The Lab Report

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Rachel Gregory Discusses Metabolic Flexibility (Rebroadcast)

Fri, 30 Jul 2021 10:00:00 +0000

Rachel Gregory is a Board Certified Nutritionist, a health and wellness specialist, author, and the creator of MetFlexLife, a platform that provides educational content as well as coaching services in achieving optimal health. She champions the ketogenic lifestyle, but also advocates for a more tailored approach as opposed to a cookie-cutter method for her clients. Rachel is also the author of the 21-Day Ketogenic Diet Weight Loss Challenge book, a weight loss guide that follows the ketogenic lifestyle with recipes and exercise programs.

Rachel joins us to share what it means to be metabolically flexible and how it relates to the ketogenic diet. She describes how she became passionate about training and nutrition. She explains how to make the ketogenic diet work for you and why it’s normal for a woman to struggle with the diet. Rachel also discusses the importance of accountability as well as addressing other points that affect your overall wellness, such as sleep.

“Ketosis is not a fad; it is a metabolic state.” - Rachel Gregory

This week on The Lab Report Podcast:

Who Rachel Gregory is, what she does, and her thoughts on the ketogenic diet.
The reason Rachel became fascinated with pursuing a degree in athletic training.
Why Rachel decided to switch to a nutrition-focused education.
Common misconceptions about the ketogenic diet and ketosis.
Why women struggle more with ketosis and the ketogenic diet.
Tailoring the ketogenic diet according to a person's profession and lifestyle.
Adjustments to make in the ketogenic diet once you reached a certain weight.
The importance of having someone hold you accountable for your diet.
Developing ‘carb phobia’ in light of the ketogenic trend.
Her thoughts on Crossfit and strength training.
Addressing sympathetic and parasympathetic balance.
Sleep, recovery, stress, and other factors affecting wellness.

Connect with Rachel Gregory:

Subscribe, Rate & Review The Lab Report

Don’t forget to visit our website, like us on Facebook, and follow us on Twitter, Instagram and LinkedIn. Email Patti and Michael with your most pressing questions on functional medicine.

For medical advice, diagnosis, and/or treatment, please consult a medical professional.

See omnystudio.com/listener for privacy information.

Heber Cannon & the Resurgence of CrossFit

Tue, 27 Jul 2021 10:00:00 +0000

Heber Cannon is an accomplished documentary filmmaker who travels the world to capture the fittest people on the planet in action. Along with his partner Marston Sawyer, they are known as the “Buttery Bros” and they have taken YouTube and social media by storm. But, they also ‘walk the walk’ as it relates to health and fitness and are themselves CrossFit enthusiasts. By sitting at the feet of the fittest people in the world, Heber has a unique perspective on health and wellness and an ability to make it fun and entertaining.

In today’s episode, Heber talks all things ‘butter’ in the world of diet and exercise, and we hear about his latest film “Resurgence”.

Report Today on The Lab:

2:50 Heber Cannon explains his love of butter, fitness, and film making
5:15 How are elite athletes different?
6:30 The importance of nutrition and diet
9:00 Buttery Bros, the brand - on YouTube and everywhere
12:00 The Resurgence of CrossFit
14:35 CrossFit Games 2021
15:45 The Fireball
16:55 Michael needs parenting advice

Additional Resources:

butterybros.com

Resurgence trailer

Buttery Bros - YouTube

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Dr. Sara Gottfried on Women, Food, & Hormones

Fri, 23 Jul 2021 10:00:00 +0000

In today’s episode, we discuss the interconnection of hormones with diet and the microbiome, and we hear about her approach to bio-identical hormone replacement therapies.

Today on The Lab Report:

3:20 Meet Dr. Sara Gottfried and hear her journey to root cause medicine
8:50 Diet, metabolism, and hormones
12:45 Pre-diabetes and continuous glucose monitoring
14:35 Heart rate variability testing and cortisol
17:00 When to use bio-identical hormone replacement
20:20 Cortisol’s effects on other hormones
22:25 The role of the microbiome
25:25 Dosing and timing of hormone replacement
30:50 How you can work with Dr. Gottfried
31:50 The Fireball

Additional Resources:

saragottfriedmd.com

Marcus Institute of Integrative Health

Women, Food, & Hormones

The Hormone Reset Diet

The Hormone Cure

Brain Body Diet

Younger

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Nick Shaw - The Renaissance Periodization Approach

Tue, 20 Jul 2021 10:00:00 +0000

Renaissance Periodization is a one-of-a-kind coaching program. Their team of medical doctors, trainers, dieticians, PhD researchers, and athletes provides an evidence-based approach to athletic coaching and nutrition education to help clients achieve their personal goals. The founder and CEO of this unique company is Nick Shaw, himself a competitive powerlifter, bodybuilder, and coach.

On today’s episode, we discuss some practical tips for lifestyle and dietary change with Nick Shaw and learn why Renaissance Periodization is not your ordinary coaching program.

Today on The Lab Report:

3:30 Meet Nick Shaw and learn about Renaissance Periodization’s team
6:40 Coaching elite athletes versus the general population
9:00 Caloric restriction for weight loss
13:20 Thoughts on strict diets: keto, carnivore, etc.
15:50 RP Diet Coach app and artificial intelligence
18:30 Motivation, work ethic, and lifestyle change
21:30 Where to start with Renaissance Periodization
23:25 The Fireball

Additional Resources:

Renaissance Periodization

RP Strength Podcast

RP Diet Coach App

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Dr. Ben Bikman on Why We Get Sick (Rebroadcast)

Fri, 16 Jul 2021 10:00:00 +0000

Many of us know insulin as the hormone that regulates our blood sugar. We often think of its role in diabetes. However, insulin affects far more than glucose. Dr. Ben Bikman is a PhD researcher who has been studying insulin for many years. His latest book, Why We Get Sick, outlines how insulin resistance is at the root of chronic disease and ways to treat and prevent it.

In this episode, we speak to Dr. Bikman about the mechanisms of insulin resistance, its far-reaching effects in chronic disease, and strategies to improve it.

Today on The Lab Report:

2:20 Meet Dr. Bikman and learn why he focuses his research on insulin
8:35 Insulin and insulin resistance
13:55 Where in the body does insulin resistance start?
18:25 Hypertrophic vs. hyperplastic fat cells and the effects of free fatty acids
26:35 Signals that create hypertrophic vs. hyperplastic fat cells
28:45 Muscle-centric model of insulin resistance
32:15 Chronic diseases as they relate to insulin resistance
35:50 Aromatase activity in adipose tissue
37:25 The brain and Alzheimer’s disease as ‘type 3 diabetes’?
41:50 Fasting, ketosis, and lifestyle strategies to combat insulin resistance
47:35 COVID-19, immunity, and metabolic defenses
50:40 The Fireball

Additional Resources:

Why We Get Sick

Ceremides as modulators of cellular and whole-body metabolism

Adipose Tissue as an Endocrine Organ

Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics

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The Champion Mindset with Carey Kepler

Tue, 13 Jul 2021 10:00:00 +0000

Carey Kepler is a wife, mother, business owner, motivational speaker, top-ranked athlete, and coach. She spends her life helping others to develop a ‘Champion Mindset’ to create and live the life of a champion both inside and outside the gym. Carey teaches the importance of goal setting and the need to continually re-evaluate those goals for success in lifestyle change.

In today’s episode, we talk to Carey Kepler about her amazing athletic career and her passion for helping her clients stay motivated and consistent.

Today on The Lab Report:

3:20 Learn about Carey Kepler and her lifelong athletic journey
9:15 The Champion Mindset
11:00 Why coaching women is different
13:30 Proper goal setting for change
17:20 Strategies for work-life balance
23:50 Supporting clients through the pandemic
28:35 Want to work with Carey?
30:30 The Fireball

Additional Resources:

CoachCareyKepler.com

CrossFit Central

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Dr. Christian Jenski - Let's Get Clinical!

Fri, 09 Jul 2021 10:00:00 +0000

Dr. Christian Jenski is a conventionally trained emergency room physician who has made the huge leap to functional medicine. In addition to running a burgeoning practice in Richmond, VA, he keeps his skills sharp by simultaneously working shifts in a busy ER. This gives him unparalleled insight into the way conventional and functional medicine can complement each other. In fact, he believes it has made him a better ER physician.

In today’s episode we discuss Dr. Jenski’s approach to functional medicine, how he clinically applies testing, and real-world examples showcasing the power of root-cause medicine.

Today on The Lab Report:

3:15 Meet Dr. Jenski and learn about his journey to functional medicine
9:45 Transitioning his practice to functional medicine
12:55 Richmond Integrative & Functional Medicine
16:00 Where to start with testing?
18:05 Case studies using the GI Effects Stool Profile
31:20 NutrEval and Metabolomix + in clinical practice
34:30 Root causes of hormonal imbalance vs. hormone supplementation
39:00 The Fireball

Additional Resources:

Richmond Integrative & Functional Medicine

Hitting Cancer Below the Belt

The Ultimate Guide To Intermittent Fasting For Women

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Julia Glanz: The role of diet & fitness in Women's Health

Tue, 06 Jul 2021 10:00:00 +0000

Functional medicine is all about getting to the root cause of a patient’s complaints. Women’s health can present a unique challenge since hormonal fluctuations need to be considered. Today we meet Julia Glanz. Julia is a registered dietitian with a master’s degree in nutritional science, a certified strength and conditioning coach, and an author. She has an online nutrition practice where she specializes in women’s health and works with women to optimize the key hormones affecting their energy, metabolism, and body composition through strategic nutrition and lifestyle changes.

On today’s episode Julia Glanz discusses the role of diet, nutrition, and lifestyle when it comes to optimizing women’s health.

Today on The Lab Report:

2:35 Meet Julia Glanz and hear her journey to nutrition and coaching
7:45 Helping a client choose a diet
10:30 Do we need supplements?
13:00 Intermittent fasting in women
16:05 Stress and cortisol in weight gain or causing a plateau
21:10 Mindfulness and food
24:30 Motivation and consistency
28:50 Women’s Guide to Health, Hormones, & Metabolism
32:15 The Fireball

Additional Resources:

@juliaglanz Instagram

A Woman's Guide To Optimizing Health, Hormones, & Metabolism

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Dr. Paul Saladino on the Carnivore Diet & Plant Toxicities [Rebroadcast]

Fri, 02 Jul 2021 10:00:00 +0000

Dr. Saladino is the leading authority on the science and application of the carnivore diet. He has used this diet to reverse autoimmunity, chronic inflammation, and mental health issues in hundreds of patients, many of whom had been told their conditions were untreatable. In addition to his personal podcast, Fundamental Health, he can be found featured on numerous podcasts including The Minimalists, The Joe Rogan Experience, The Model Health Show, Bulletproof Radio, The Dr. Gundry Podcast, The Ben Greenfield Podcast, Dr. Mercola, Health Theory, Mark Bell’s Power Project, and many others. He has also appeared on The Doctors TV show and authored the bestselling book, “The Carnivore Code: Unlocking the Secrets to Optimal Health by Returning to our Ancestral Diet.”

This week on The Lab Report Podcast:

Why Paul decided to focus his career on the carnivore diet.
What the "Carnivore Diet" is.
How the human body responds to plant toxins.
The composition of the human diet in the last two million years.
How being carnivorous could have helped humans evolve.
Paul's thoughts on polyphenols and phytonutrients.
What hormesis is and where the idea came from.
Why plant compounds have redundant benefits with ignored side effects.
Paul's thoughts on short chain fatty acids and the effects of fiber on gut bacteria.

Connect with Dr. Paul Saladino:

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Don’t forget to visit our website, like us on Facebook, and follow us on Twitter, Instagram and LinkedIn. Email Patti and Michael with your most pressing questions on functional medicine.

For medical advice, diagnosis, and/or treatment, please consult a medical professional.

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THE Ben Greenfield!

Tue, 29 Jun 2021 10:00:00 +0000

Ben Greenfield is a fitness guru and NY Times Best Selling author leading the field of human performance and biohacking. His unique voice and influence in the health and fitness industry have paved the way to optimal health for thousands and thousands of people. Ben’s teaching platforms, podcasts, and books offer the latest research on longevity, athletic performance, and anti-aging.

On today’s episode, Ben discusses some practical biohacking tips and the importance of identifying and fulfilling your life purpose.

Today on The Lab Report:

3:00 Ben Greenfield discusses his fitness journey
10:20 What is ‘biohacking’?
13:10 Practical life changes for optimal health
20:40 Ben’s take on ‘diets’
27:20 Mindfulness, breathwork, and gratitude practices
30:55 Importance of a purpose statement
34:00 Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging
36:50 The Fireball

Additional Resources:

Ben Greenfield Fitness

Fit Soul, Fit Body: 9 Keys to a Healthier, Happier You

BoundlessBook.com

Ben Greenfield Coaching

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Dr. Jeffrey Bland - The Father of Functional Medicine

Fri, 25 Jun 2021 10:00:00 +0000

Anyone practicing functional medicine, or those patients whose lives have been changed because of it, owe a debt of gratitude to the vision of Dr. Jeffrey Bland. Dr. Bland’s teaching, writing, and research have helped this field to evolve over the past several decades. His latest venture, Big Bold Health, focuses on personalized and global immunity while espousing environmental stewardship.

Today we discuss the history of functional medicine, the legacy of Dr. Jeffrey Bland, and his latest work on immunity.

Today on The Lab Report:

2:30 Jeffrey Bland on the history and future of functional medicine
8:00 Functional medicine approach to long-haul COVID
13:50 Big Bold Health and personalized immunity
18:05 Global immunity
22:40 The story of Dutch Harbor Omega capsules
26:40 Himalayan Tartary Buckwheat
31:20 Personalized Lifestyle Medicine Institute (PLMI)

Additional Resources:

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Dr. Sylvia Tara on the Secret Life of Fat

Tue, 22 Jun 2021 10:00:00 +0000

Many of us struggle with weight and fat loss. But fat, or adipose tissue, has many other functions in the body that may be working against your ability to lose weight. Dr. Sylvia Tara holds a PhD in biochemistry and has dedicated years of research to fat and the ways adipose tissue can work as an endocrine organ in signaling your brain to alter hunger and satiety.

Today we discuss Dr. Tara’s book called “The Secret Life of Fat” which outlines the latest information on fat’s role in the body and why you might be struggling with weight loss.

Today on The Lab Report:

3:05 Meet Dr. Sylvia Tara and hear why she chose to study fat
6:25 Fat as a villain fueling the growth of the diet industry
9:20 Weight loss myths and fat as an endocrine organ
14:00 Lesser known ways we gain fat and practical tips to control it
18:50 Fasting, circadian rhythms, and obesogens
22:10 Exercise and hormonal signaling to different types of fat
27:55 Weight gain during the pandemic and the mental-emotional component
34:40 Tara’s online program to practically apply these principles
37:10 The Fireball

Additional Resources:

The Secret Life of Fat

Dr. Tara's Online Course

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Dr. Kelly Starrett: Mobility & The Ready State (Rebroadcast)

Fri, 18 Jun 2021 10:00:00 +0000

REBROADCAST: The basics of mobility often go unnoticed until nagging pain and discomfort arise. Musculoskeletal pain is a very common complaint of many patients. Rather than treating that pain with medication, what if a simple mobility technique could fix the mechanics that caused it? Dr. Kelly Starrett has revolutionized the way we assess and treat common aches and pains by developing a program called The Ready State. His years of working with elite, professional athletes gives him a unique perspective on how to deal with common everyday musculoskeletal issues.

In this episode, Dr. Starrett lays out a simple plan that clinicians can use every day to assess and treat their patients with pain. He also discusses some strategies for those with desk-based jobs trying to survive the modern workplace and outlines the basics of good posture.

“Pain is the body’s request for change.” – Dr. Kelly Starrett

Today on The Lab Report:

2:50 Meet Dr. Kelly Starrett and get introduced to the idea of mobility
8:30 Kelly’s experience with functional medicine
11:00 Adequate vs. Optimal
15:20 What is a supple leopard?
18:50 Prescribing mobility – the movement map
26:25 Deskbound and strategies for the workplace
32:40 Posture and the skill of standing
37:20 The Ready State

Additional Resources:

The Ready State

Becoming a Supple Leopard

Deskbound: Standing Up to a Sitting World

Ready to Run: Unlocking Your Potential to Run Naturally

Waterman 2.0

Muscles and Meridians

Stand Up Kids

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Shedding Some Light on Sunscreen

Tue, 15 Jun 2021 10:00:00 +0000

Summer is here and with that comes longer days and more sun exposure. The health benefits of sunshine include increased vitamin D production, elevated mood, stronger bones, and even better sleep. However, overexposure to the sun can damage our skin and lead to skin cancer over time. Using sunscreen can help to protect our skin, but where’s the line when it comes to blocking vitamin D production or absorbing potentially harmful chemicals?

In today’s episode, we debate the pros and cons of using sunscreen and tell you why you should pay closer attention to what’s actually in it.

Today on The Lab Report:

4:35 Sunscreen and the role of the skin
6:10 Types of ultraviolet light
8:40 What about vitamin D?
10:30 Skin cancer, vitamin D, and the sun
13:55 Chemical sunscreens - exposures and toxicity?
18:30 Mineral-based sunscreens as an option

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Nettles - They're Worth the Sting

Fri, 11 Jun 2021 10:00:00 +0000

Stinging nettle (Urtica dioica) is a perennial, flowering plant with many medicinal uses. Not only is it nutrient dense, but it has been used as a diuretic and therapeutically for various inflammatory conditions. However, the plant really does sting! It contains hair-like needles on the leaves and stems to protect itself from herbivorous animals. The injection of histamine and other chemicals causes a local inflammatory response and sometimes paresthesia.

Today we discuss this multi-faceted herb, its nutritional value, and ways to use it medicinally with our favorite herbalist, Greg Monzel.

Today on The Lab Report:

3:00 Stinging Nettle – hey! Let’s call Greg Monzel!
4:20 All about the sting – the good and bad
10:10 Nutritionally speaking
11:35 Important clinical uses of nettles
14:40 Removing and dealing with the sting
17:00 Cooking, tasting, and beer!
18:40 Nettles seeds – waving and renal disease
22:50 The roots! ..... and the stem?
25:50 Wild Persimmon School of Wellness

Additional Resources:

Stinging Nettle-Light-micrograph

Wild Persimmon Wellness

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Chronic Fatigue Syndrome?

Tue, 08 Jun 2021 10:00:00 +0000

Chronic Fatigue Syndrome is a complex and evolving illness that is highly misunderstood. In fact, coming to a consensus within the medical community on diagnostic criteria and actual naming convention has been challenging. Newer governing bodies have begun calling it ‘Systemic Exertion Intolerance Disease’ or SEID. Regardless of the inconsistencies, the emotional, physical, and economic impact of this disease can not be ignored.

Today we break down the history of ‘chronic fatigue syndrome.’ We also dive into the literature around diagnosis, workup, and treatment options.

Today on The Lab Report:

3:05 History of ‘Chronic Fatigue Syndrome’
6:00 Evolving diagnostic criteria
8:45 Pathophysiology - starting with the brain
10:25 Scienceness, Technocology, and Machinamechanics
11:45 Immunology, HPA axis, autoimmunity, and mitochondrial dysfunction in SEID
13:35 Is there a diagnostic test?
15:15 “What is It?!”
18:35 Treatment strategies and therapies

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Xenobiotics!

Fri, 04 Jun 2021 10:00:00 +0000

Environmental toxins are seemingly everywhere in our daily lives. These synthetic substances which are not usually found in our bodies are known as xenobiotics. Given the ubiquitous nature of xenobiotics and their effects on our health, trying to be mindful of them and avoiding them can seem difficult – especially if you don’t realize they exist!

In today’s episode, we discuss three common xenobiotics that can interrupt hormone metabolism, contribute to obesity, and are associated with many chronic health conditions – bisphenol A (BPA), polychlorinated biphenyl (PCB), and phthalates.

Today on The Lab Report:

3:35 Defining Terms: Xenobiotics
5:35 What is BPA and why should we care?
8:10 Endocrine Disruptors and Obesogens
10:55 Polychlorinated biphenyl – PCBs
15:25 Phthalates exposure
18:50 What can we do about all of these toxic exposures!?

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A Podcast for the AGEs

Tue, 01 Jun 2021 10:00:00 +0000

Summer is nearly here, and that means backyard barbecue season. Cooking certain foods with high heat causes something called the “Maillard Reaction” – which is a chemical reaction between fat, proteins, and sugars that gives browned and seared foods, like barbecued meats, their flavor. The result of this reaction is the formation of advanced glycation end products or AGEs. High amounts of AGEs have been implicated in many chronic health conditions.

In today’s episode, we explain what AGEs are, tell you which foods naturally contain AGEs, and ways to mitigate their harmful effects.

Today on The Lab Report:

3:15 Defining AGEs and the Maillard Reaction
5:50 How do AGEs cause a problem in the body?
7:25 Naturally occurring AGEs
10:15 Patti & Michael “Talk it Out”
13:20 Getting rid of AGEs and mitigating their effects
14:40 RAGEs, AGEs, chronic disease, and therapies
16:20 Question of the Day?
- Can we get insight on AGE effects using Genova tests?

Additional Resources:

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Stool Testing Under the Influence

Fri, 28 May 2021 10:00:00 +0000

A very common question we are asked as it relates to functional medicine testing is how medications and supplements affect results. Although we can’t always know the influences, based on physiology and some literature we can make educated guesses. Genova never recommends that any patient discontinue medically necessary medications for the purposes of testing – that decision is up to the ordering clinician. But it might be helpful to discuss what to expect when interpreting results.

In today’s episode, we talk about ways medications and supplements can influence results of the GI Effects Stool Profile and how some can interfere with our ability to perform testing.

Today on The Lab Report:

3:00 Collection pack instructions and the disclaimer
5:00 Interferents vs. influencers
7:10 Laxatives
10:40 Digestive enzymes
11:50 Better Know a Biomarker
16:40 Antimicrobial meds and supplements
19:20 Proton pump inhibitors and antacids
20:35 Aspirin, NSAID’s, and steroids
22:00 Question of the Day?
- Where can people access this information for themselves?

Additional Resources:

Lose Weight and Feel Great Forever

Test Prep Page

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Patti & Michael Break Down Biofilms

Tue, 25 May 2021 10:00:00 +0000

In today’s episode, we dive into the topic of bacterial biofilms- when to suspect them and ways to treat them.

Today on The Lab Report:

4:00 What are biofilms?
6:05 EPS, persister cells, and quorum sensing
8:40 Clinical importance and redeeming qualities?
11:35 Treating biofilms
13:20 Antimicrobial lipids
14:55 “What is it?”
18:50 Biofilm take-home points

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NAC...Drug or Super Supplement?

Fri, 21 May 2021 10:00:00 +0000

Today we talk all about N-acetylcysteine - the ways NAC is used and its importance in health and disease.

Today on The Lab Report:

2:45 NAC as a drug in acute care settings
4:00 Mechanisms of action in the lung and kidney
7:15 NAC as a daily supplement
10:00 Hmmm…so is it a medication or a supplement?
11:15 Generic drug or herbal constituent?
15:00 Research on NAC in psychiatric disorders
16:16 NAC in polycystic ovary syndrome and fertility
17:40 Safety and side effects
18:50 Question of the Day:
- What are the other precursors to glutathione and how do we measure them?

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Take Control of Your Fitness with Miranda Alcaraz

Tue, 18 May 2021 10:00:00 +0000

Miranda Alcaraz has been a health and fitness influencer for nearly 20 years. As an athlete, entrepreneur, and a busy mom she understands the challenges we all face when trying to fit exercise into our daily schedules. She and her husband Julian created an online fitness community called “Street Parking” offering at-home, daily exercise routines and nutritional coaching to help people achieve their goals through the power of community.

Today we meet Miranda Alcaraz, and discuss coaching athletes and non-athletes, pregnant and post-partum women, and her “More than Nothing” approach to consistency and creating habits that last.

Today on The Lab Report:

2:55 Meet Miranda Alcaraz and hear about her journey to fitness
6:50 Lessons learned from injury
9:45 “Street Parking”
11:55 Training athletes vs. non-athletes
14:05 Pregnancy and postpartum fitness
18:25 Fitting in a workout as a busy parent
22:30 Personalizing an approach to nutrition
26:25 The Fireball

Additional Resources:

Street Parking

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Zack George - The UK's Fittest Man

Fri, 14 May 2021 10:00:00 +0000

Zack George is a top CrossFit athlete, coach, trainer, and author. His journey from overweight teenager to the fittest man in the United Kingdom is a story of resolve and resiliency. We all struggle with motivation and goal setting, but Zack serves as an example of what is possible. Through his online training program “Team Silverback”, his local UK gym, and new book “Start Where Others Stop”, he helps others achieve long-term lifestyle change.

In today’s episode, we meet Zack and discuss his athletic success, his challenges, and the importance of setting goals.

Today on The Lab Report:

3:25 Meet Zack George and hear about his catalyst for change
8:10 Disappointing injury and turning setbacks into positivity
11:15 Finding a balance with rest and recovery
12:40 Pain and overtraining
14:05 Motivation and goal setting
17:00 Zack’s approach to nutrition
19:25 “Start Where Others Stop”
21:15 Team Silverback and CrossFit BFG
25:45 The Fireball

Additional Resources:

Team Silverback

Start Where Others Stop

CrossFit BFG

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Dr. Ara Suppiah - A Masterclass in Functional Sports Medicine

Tue, 11 May 2021 10:00:00 +0000

Dr. Ara Suppiah is a pioneer in bringing functional medicine to the professional sports arena. As the Chief Medical Analyst for NBC’s ‘The Golf Channel’, medical contributor to Golf Digest, and personal physician on the PGA and ATP tours, he’s worked with top athletes across the globe to optimize their health and performance using functional medicine principles and testing. Although most of us are not professional athletes, his insight and knowledge when it comes to treating them can translate to practical tips we can all use in our daily lives.

Today we learn about Dr. Ara Suppiah’s journey to functional medicine, his approaches to nutrition, rest, and pain, and how he applies Genova’s tests.

Today on The Lab Report:

3:40 Meet Dr. Ara Suppiah!
12:15 What sets professional athletes apart?
18:35 Ara loves/hates Michael’s jingles
19:10 Nutrition and using Genova’s testing in professional sports
24:05 Addressing acute and chronic pain
28:35 The importance of rest and recovery
34:10 Ara’s online education programs
37:45 The Fireball

Additional Resources:

Dr. Ara's website

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Migraines are a pain...

Fri, 07 May 2021 10:00:00 +0000

We’ve all had headaches, and some can be severe. Although many people use the words ‘migraine’ and ‘headache’ interchangeably, the physiology and syndrome of migraines is actually a bit different. Rather than suffer with the debilitating nature of migraines, what if there were practical tips to mitigate their effects or prevent them from occurring in the first place?

In today’s episode, we define the difference between primary headaches and migraines, we uncover some of the main migraine triggers, and discuss practical tips to help you get to the root cause.

Today on The Lab Report:

3:00 Difference between migraines and other headaches
6:30 Food as a trigger
7:30 Hormonal influences on migraines
8:45 The role of the gut-brain axis
9:30 Intestinal permeability, inflammatory cytokines, and SCFA’s
10:30 Neuropeptides, glutamate, CGRP, serotonin
14:55 Logical Speculation – Serotonin and migraines
17:45 Nutritional therapies: Vitamin D, fish oil, and CoQ10

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What's All This About Fiber?

Tue, 04 May 2021 10:00:00 +0000

Dietary fiber is an important part of a healthy diet and many of us don’t get nearly enough. Research suggests fiber is important for a healthy microbiome and can positively affect many chronic diseases. For as simple as fiber may seem, there are many confusing terms that accompany it – soluble, insoluble, resistant, fermentable, viscous etc. What kind do we need? Why does it matter?

In today’s show, we break down the different types of fiber, discuss common food sources, and outline some important health benefits to increasing the fiber in your diet.

Today on The Lab Report:

4:05 What is fiber and solubility?
6:10 Insoluble vs. soluble fiber and viscosity
8:45 Clinical uses of each and specific dietary sources
13:20 Fiber’s unique role in the microbiome
16:45 Beneficial systemic effects of fiber in chronic conditions
17:50 Question of the Day
- How much fiber should we be getting each day?

Additional Resources:

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The Power of Polyphenols

Fri, 30 Apr 2021 10:00:00 +0000

Polyphenols are chemical nutrients found in many foods – though mainly in plants. Much of the research in polyphenols surrounds their anti-inflammatory and antioxidant properties. They also have important influences in the microbiome. Dark fruits, red wine, chocolate, green tea, olive oil, and soy are a just a few of the many foods that provide excellent sources of polyphenols.

Today we discuss several subclasses of polyphenols, why they are important, and how to get them in your diet.

Today on The Lab Report:

2:40 Defining Terms!
4:30 General health benefits of polyphenols
5:40 The flavonoids
7:45 Anthocyanins, lignans, and stilbenes
9:45 Food court: making the case for bananas, blueberries, and pomegranates
19:25 Question of the Day
- How do dietary polyphenols affect NutrEval results?

Additional Resources:

Tactic Functional Nutrition

Organic Acids

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Meredith Root - Coaching Up Lifestyle Change

Tue, 27 Apr 2021 10:00:00 +0000

Behavior change is difficult. Many of us understand that nutrition and movement are important, but how do we take this information to the next level for long-term lifestyle change? Today we meet Meredith Root. She is a very successful and accomplished CrossFit athlete, trainer, and coach. She also has a biological science background and a keen understanding of nutrition as it relates to performance. She co-founded a global nutritional coaching company and helps athletes and non-athletes alike to create sustainable change.

In today’s episode, we discuss Meredith’s approach to nutrition and coaching. She offers practical tips that she uses with her clients to support them on their health journey.

Today on The Lab Report:

3:00 Meet Meredith Root – hear about her path from scientist to coach
7:15 The Tactical Functional Nutrition program
10:15 Teaching the importance of nutrition
11:30 Diets and fasting in athletes
14:20 Practical tips for maintaining motivation over time
20:20 Meredith’s writing
21:50 The Fireball

Additional Resources:

Morning Chalk Up

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Patti & Michael Talk Pet Therapy

Fri, 23 Apr 2021 10:00:00 +0000

Many of us have pets and consider them part of the family. They offer emotional support, companionship, and bonding. Did you know that they are very important for your health? Beyond pets, the medical field is now recognizing the healing qualities of many types of animals. Animal-assisted therapies are being incorporated into clinical treatment plans to improve health outcomes in many chronic conditions and diseases.

Today we dive into the concept of animal-assisted therapy. We take a look into the literature as it relates to psychological outcomes, cardiovascular disease, and more.

Today on The Lab Report:

2:35 Pets and the state of the literature
5:55 Effects of animal-assisted therapy in depression
9:42 Animals for anxiety and schizophrenia
11:00 Pet ownership vs. animal-assisted therapy
12:20 Get Outta Here!
14:20 Chickens, neurotransmitters, and hormones
15:50 Biophilia hypothesis
19:00 Question of the Day:
- What are the differences between service animals, therapy animals, emotional support animals, and working animals?

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Dr. Nathan Jenkins Discusses Metabolic Flexibility

Tue, 20 Apr 2021 10:00:00 +0000

Metabolic flexibility is the ability of your body to use whatever food you are eating for energy. In patients with metabolic dysfunction, the body may not be able to adapt well in using different energy sources. Dr. Nathan Jenkins is an integrative exercise physiologist who leads a team of researchers at the University of Georgia studying the effects of exercise on cardiovascular and metabolic health. His team is responsible some of the cutting edge of the latest research around metabolic flexibility.

In today’s episode, Dr. Jenkins defines metabolic flexibility, how he measures it in the laboratory, and lays out the state of the most current evidence.

Today on The Lab Report:

3:10 Meet Dr. Jenkins and hear why he studies exercise physiology
8:05 Metabolic Flexibility and how it’s measured
12:08 Fast/slow metabolism and basal metabolic rate
15:40 The importance of postprandial fat oxidation
23:00 Types of exercise on metabolic flexibility
29:20 Maximizing metabolic flexibility by timing food and exercise
32:50 Ketogenic diets and exercise
39:42 The Fireball

Additional Resources:

Acute exercise effects on postprandial fat oxidation: meta-analysis and systematic review

Tabata-style functional exercise increases resting and postprandial fat oxidation but does not reduce triglyceride concentrations

UGA Integrative Cardiovascular Physiology Laboratory

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Cinnamon!

Fri, 16 Apr 2021 10:00:00 +0000

Cinnamon is a spice condiment found in nearly everyone’s kitchen cabinet. It is so versatile in flavoring foods, beverages, candy, and personal care products. But very few of us realize the vast array of medicinal uses for cinnamon. It can be used as a natural supplement to support metabolism, the immune system, the GI tract, and more!

In today’s episode, we discuss the many uses for cinnamon and its wide array of potential health benefits.

Today on The Lab Report:

3:50 Cinnamon is a powerhouse!
5:05 Insulin, blood sugar, lipids, and oxidative stress
7:00 Eating cinnamon vs. supplementation
8:30 Inflammation and cancer
10:30 Where does cinnamon come from?
13:40 Cinnamon in the GI tract
17:00 Michael’s “side-project”

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Dr. Nicole Avena on Fertility and Nutrition

Tue, 13 Apr 2021 10:00:00 +0000

Fertility rates have been dropping due to environmental toxicities, higher incidence of obesity and metabolic dysfunction, and couples waiting until later ages to conceive. But it is important to understand that there are many things we can do to improve fertility and optimize preconception health. Dr. Nicole Avena is a PhD researcher who is widely published on the health effects of nutrition. Her most recent book "What to Eat When You Want to Get Pregnant," outlines the latest research on how nutrition can improve fertility and which foods might actually be hindering couples looking to conceive.

Listen in as Dr. Avena discusses which nutrients are important for both men and women when it comes to fertility.

Today on The Lab Report:

3:35 Meet Dr. Nicole Avena and hear why she wrote her latest book
7:15 Important nutrients for fertility
8:50 Testing and physical exam for nutrient deficiencies
9:45 Male fertility, nutrition, toxins
12:55 Are there concerns for vegan and vegetarian patients?
14:30 Seemingly 'healthy' foods which hinder fertility
17:30 Other metabolic concerns
19:35 Sugar in preconception care
20:25 The Fireball

Additional Resources:

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Food Additives - Hidden in Plain Sight

Fri, 09 Apr 2021 10:00:00 +0000

In today’s episode, we discuss just a few additives you might want to keep an eye out for next time you go to the grocery store.

Today on The Lab Report:

3:20 MSG – monosodium glutamate
6:40 Nitrites and nitrates
9:55 The “Name that Food” game
12:45 Sulfites are everywhere
13:55 Maraschino cherries are polarizing?
15:20 Sulfites as a top food allergen
16:55 Food colorings, FD&C, lakes, and blue rats
21:25 Artificial vs. natural flavoring

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Patti & Michael On The Benefits of Bone Broth

Tue, 06 Apr 2021 10:00:00 +0000

Animal protein from meat is an important part of a healthy diet. But many of us overlook further using the animal bones to provide additional healing properties. Simmering animal bones over an extended amount of time helps extract minerals, collagen, and other important nutrients into a broth. Bone broth can then be used as stock for other soups or ingested itself to improve health.

Listen in as we discuss the many health benefits of bone broth and why you should consider adding it to your diet – oh yeah, we also demonstrate how to make it – kind of.

Today on The Lab Report:

2:40 What is bone broth?
5:00 Collagen, glucosamine, chondroitin, and minerals
7:00 Gut healing properties
8:35 Detoxification support
10:00 Amino acids
10:50 Kitchen Cook-cophany!
19:10 How might bone broth effect Genova test results?

Additional Resources:

The Metabolic Effect Diet

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Dr. Jade Teta - Where Meaning Meets Metabolism

Fri, 02 Apr 2021 10:00:00 +0000

In today’s episode, we discuss Dr. Teta’s unique approach to health, diet, metabolism – and philosophy!

Today on The Lab Report:

3:25 Meet Dr. Jade Teta and learn his definition of a Next Level Human
9:25 Integrative endocrinology – a holistic approach to metabolism
12:55 The “Do What Works for You” Diet and the language of metabolism
20:15 Translating diet, lifestyle, and metabolism to patients
24:20 Wearable devices
27:00 ‘Meathead Philosopher’
31:05 The Lack of Purpose pandemic
39:30 Teta’s online teaching programs
42:50 The Fireball

Additional Resources:

jadeteta.com

Next Level Human Podcast

Human 365

Next Level Tribe

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Catecholamines, Stress, and the Reward System

Tue, 30 Mar 2021 10:00:00 +0000

Neurotransmitters act as chemical signals from our nerve endings to various target cells found in muscles, glands, and other neurons. Although there are many types of neurotransmitters, today we will focus on the catecholamines - epinephrine, norepinephrine, and dopamine. Anyone who has ongoing stress or is an ‘adrenaline junkie’ can attest to the physical effects of the catecholamines. But did you know that they also play a role in our brain’s reward system to make us happy and feel good?

Listen in as we discuss the importance of catecholamines, their downstream metabolites, and why we measure them.

Today on The Lab Report:

2:10 What is a neurotransmitter?
3:25 Introduction to catecholamines
6:00 Dopamine and the reward system
8:20 Epinephrine, norepinephrine, and the stress response
11:30 Neurotransmitter breakdown and downstream metabolites
16:50 Question of the Day
- How does caffeine affect catecholamines?

Additional Resources:

Organic Acids

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Testosterone - It's All the Rage?

Fri, 26 Mar 2021 10:00:00 +0000

Hormones are chemical messengers in the body that work together to regulate many important functions such as the stress response, growth, libido, and overall metabolism. Although our bodies make many hormones, today we are going to focus on testosterone.

Testosterone is a hormone of growth and repair and vitally important for maintaining health. Testosterone levels can naturally fall as we age. Deficiencies, or “low T”, is far more common than many of us realize and the clinical implications are far-reaching in both men and women. In this episode, we discuss all things testosterone, when to suspect deficiencies, and some strategies to improve testosterone levels.

Today on The Lab Report:

2:45 What is testosterone and what does it do?
6:15 How is testosterone made?
8:40 Declining levels and deficiencies
9:30 Get Outta Here!
12:10 Signs and symptoms of low T
14:00 What can we do about it?
16:00 Lifestyle modification and natural strategies
21:35 Supplementing with testosterone and downstream metabolism
23:20 Question of the Day
- Testosterone testing – what’s the difference between saliva, blood, and urine?

Additional Resources:

Male Hormonal Health

Complete Hormones

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Patti & Michael Discuss Nature Therapy

Tue, 23 Mar 2021 10:00:00 +0000

It seems intuitive that being outside in nature is therapeutic and beneficial to our health. What many might find surprising is the amount of clinical evidence supporting nature therapy and the specific physiologic changes that result. ‘Grounding’ and ‘earthing’ are terms that are commonly used these days but even those words under-represent the fascinating biochemical and physiologic effects of nature.

In today’s episode, we dive into the different facets of nature therapy, literature to support it, and how being outside can improve health– and hey, its Spring! Perfect timing!

Today on The Lab Report:

2:30 Intro to Nature Therapy
4:30 Let’s Define Some Terms!
6:00 “Forest bathing” and urban green space therapy
10:35 House plants and flowers
15:40 Wooden material therapy
16:30 Grounding and earthing – take off your shoes!
19:20 Question of the Day?
- Which Genova tests might apply to Nature Therapy?

Additional Resources:

Greg's website - wildpersimmonwellness.com

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St. John's Wort - All You Need to Know With Greg Monzel

Fri, 19 Mar 2021 10:00:00 +0000

The history of herbal medicine dates back thousands of years. Many of us don’t realize that our current conventional medications come from plants. Greg Monzel is an herbalist who has dedicated his life to keeping the rich history and traditions of plant medicine alive and relevant. In today’s episode, we called on him to help us unravel the mystery of St. John’s Wort.

St. John’s Wort is a very commonly used supplement as it relates to mood disorders. But why? How does it work? Where does it grow and how do we identify it? Listen as we answer all these questions and more.

Today on The Lab Report:

6:20 OMG! Greg Monzel is our favorite herbalist
9:55 The basics of St. John’s Wort
11:45 Are there medications growing in your yard?
14:45 What does St. John’s Wort look like?
17:05 Whole plant vs. constituents
19:25 John’s Wort – It’s not just for mood!
23:40 Medication interference and toxicity
27:15 Which constituent of St. John’s Wort is best?
31:45 The Fireball
33:40 What’s in a Name?

Additional Resources:

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Dr. Kien Vuu Defines the Thrive State

Tue, 16 Mar 2021 10:00:00 +0000

Dr. Kien Vuu is a physician, author, and speaker who is on a mission to empower us all to take control of our own health. His personal journey is profound and inspiring. As a young immigrant to the United States, he faced immense challenges which he overcame to become a successful doctor. Then, after developing several chronic diseases, he changed his life and found his way to health and gratitude. Dr. Vuu envisions a world where each of us fully contribute our gifts to humanity with vibrant health and vitality.

In today’s episode, we hear the incredible story of Dr. Kien Vuu and he lays out his blueprint on how to live in a Thrive State.

Today on The Lab Report:

3:10 Hear the incredible journey of Dr. Kien Vuu
9:30 From chronic disease to health
12:30 Chronic disease as a gift
15:35 The Live Again Project
18:35 Diet Eating styles, bioenergetics, and The Thrive State
25:15 Impact of the pandemic on health and thriving
28:35 The Fireball

Additional Resources:

The Unconventional Prescription: YOU are your Best Medicine

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A Functional Approach to Mood Disorders with Shae Leonard

Fri, 12 Mar 2021 11:00:00 +0000

Historically, the field of psychiatry has mainly focused on prescriptive medications and psychotherapy. Though these modalities have saved lives and stabilized many patients, there are often modifiable, underlying root causes to consider. Shae Leonard, PA is a functional medicine physician’s assistant who has spent years changing people’s lives with her functional approach to mood disorders.

Today, we talk to Shae Leonard about the effects of nutrition, gut health, hormones, genetics, and movement on mental health.

Today on The Lab Report:

4:35 Get to know Shae and her journey to functional psychiatry
8:00 The gut and other factors as root causes of mood disorders
12:00 Nutrients to optimize mental health
14:15 Using functional medicine testing
15:10 Genetics and epigenetics in mental health
18:20 HPA Axis, stress, sleep, and mood resiliency
24:45 The Fireball

Additional Resources:

Shae's Website

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Nutrition Testing: Where to Start with Dr. Dan Kalish

Tue, 09 Mar 2021 11:00:00 +0000

Interpreting functional medicine laboratory testing can be intimidating. Dr. Dan Kalish has devoted his career to teaching new functional medicine clinicians how to interpret lab results and where to start when implementing results in practice. His teaching program, The Kalish Institute, mentors and empowers practitioners within a community approach offering many online programs, videos, blogs, and personalized support.

In today’s episode, we talk to Dr. Kalish about the importance of nutritional testing, his approach to the NutrEval, and translating results.

Today on The Lab Report:

2:45 Meet Dr. Kalish!
3:55 The importance of nutritional lab testing
6:35 Where to start when using NutrEval results in practice
8:20 Functional vs. conventional labs
11:00 Translating to patients and prioritizing treatment strategies
18:30 Teaching the NutrEval and common pitfalls
22:00 Lifestyle factors in functional medicine
24:50 The Kalish Institute
27:20 The Fireball

Additional Resources:

Kalish Institute

Nutrition - Redesigned, Reimagined

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Move Over, Sliced Bread - The New NutrEval is Here

Fri, 05 Mar 2021 11:00:00 +0000

Genova’s nutritional profiles are breaking new ground. The NutrEval, and its subpanels, have been redesigned and reimagined to offer even greater clinical utility! Our nutritional profiles help practitioners identify root causes of dysfunction and treat clinical imbalances that are inhibiting optimal health. These advanced diagnostic tools provide a systems-based approach for clinicians to help their patients overcome chronic conditions and live a healthier life.

On today’s episode, we discuss the new features of the upgraded NutrEval report and give some clinical insight into the new biomarkers and functional pillar scoring system.

Today on The Lab Report:

2:00 – Welcome to the brand new NutrEval
3:14 – Nutrition & Functional Imbalances
4:23 – The 5 Functional Pillars
6:04 – Nutritional Needs Assessed on the NutrEval
7:39 – Pathways, Mitochondrial Dysfunction, and Oxidative Stress
9:16 – The Organic Acids
11:29 – Better Know The New Biomarkers
13:07 – Google It: Is Corn a Vegetable?
14:32 – alpha-hydroxybutyric acid & oxalates
17:02 – Organic acid categories
19:24 – The Amino Acids
21:14 – The Fatty Acids
23:08 – Nutrient & Toxic Elements
24:07 – Question of the Day: Updates to other Nutritional Profiles?

Additional Resources:

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THE Dr. Patrick Hanaway!

Tue, 02 Mar 2021 11:00:00 +0000

Dr. Patrick Hanaway is a key thought leader and educator in functional medicine. After decades of work, his contribution and influence in our field continues to this day. His task force leadership at IFM during the pandemic helped to shape the functional medicine approach to COVID-19. Also, as prior Chief Medical Officer for Genova Diagnostics, he helped to create the NutrEval Profile as we currently know it.

In today’s episode, we discuss what we’ve learned over the past year regarding COVID-19, and the how functional medicine approach can improve outcomes. We also get his take on the new NutrEval and how to use it in practice.

Today on The Lab Report:

2:45 Welcome back Dr. Hanaway!
4:25 What have we learned about COVID-19?
12:45 Nutrient supplements during the pandemic
18:41 Functional approach to SARS-CoV-2
20:45 The NutrEval in practice
30:00 Can we get all we need from a balanced diet?
36:30 Systems-based interventions in chronic disease
42:40 Relationships and connection while in lock-down
49:30 The Fireball

Additional Resources:

IFM COVID Resources

Dr. Hanaway's Website: Family to Family

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Oxalates!

Fri, 26 Feb 2021 11:00:00 +0000

Oxalates are organic acids that can be made in the body, but they are also found in various foods. Many people associate oxalates with a risk for kidney stones. There are many claims about the dangers of oxalates and the need to avoid high oxalate foods. But, are these claims valid? Should we be afraid of oxalates? Why should we measure them and what do they mean?

In today’s episode, we dive into the biochemical glyoxylate pathway. We also explain how the body makes and metabolizes oxalates, the role of the gut microbiome, and how to interpret oxalate levels.

Today on The Lab Report:

4:15 The Glyoxylate Pathway - what is an oxalate?
6:35 Glyoxylate is the hub!
8:50 Two off-shoots of glyoxylate: oxalic acid and glycolic acid
9:50 Oxalic acid – kidney stones and beyond
14:07 Logical Speculation: Oxalic Acid and Metabolic Syndrome – cause vs. effect
16:50 Glycolic acid, glutathione, and oxidative stress
19:30 Glyceric acid
21:00 Question of the Day
- What is systemic oxalosis and should we be worried about it?

Additional Resources:

Glyoxylate Pathway Chart

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All Things Nutrition With Dr. Filomena Trindade

Tue, 23 Feb 2021 11:00:00 +0000

Dr. Filomena Trindade has been practicing and lecturing about functional medicine for over 25 years. She has been a leading expert in diabesity and metabolic medicine. Additionally, Dr. Trindade’s mentorship programs and teaching style have been transformative for many clinicians new to this field.

We often find in functional medicine, that inadequate nutrition can be the root cause of chronic medical conditions. And, during the global pandemic, this becomes vitally important as patients and clinicians are looking to optimize immunity.

In today’s episode, we talk all things nutrition and discuss the role of specific nutrients in immunity and optimal health. We also discuss the role of mentorship in practice implementation.

Today on The Lab Report:

2:40 Azores and archipelagos
3:35 Welcome back Dr. Filomena Trindade!
6:15 Optimizing immunity, nutrition, and COVID
12:20 Supplements, food sources, and root causes
15:05 Carbs and CGM
17:30 Saturated fat, cooking oils, and eating farm-to-table
22:40 Ketosis, fasting, and metabolic flexibility
24:30 The importance of mentorship
30:40 The Fireball

Additional Resources:

Dr. Trindade’s website

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Patti & Michael Deal With Oxidative Stress (Rebroadcast)

Fri, 19 Feb 2021 11:00:00 +0000

What are free radicals and oxidative stress? How do free radicals impact the health and wellness of our patients? Why should clinicians analyze and measure a patient’s free radicals and oxidative stress levels? What can this information tell us about our patient’s overall health and their risk of developing a chronic disease?

Today, we simplify the complex topic of free radicals and their connection to oxidative stress. We discuss the benefits and drawbacks of free radicals in your body and how antioxidants can help you decrease them while eliminating oxidative stress levels. We discuss what commonly causes free radicals to develop in your body and where we can find the best sources of antioxidants. We also discuss the connection between chronic diseases and high levels of free radicals as well as the correlation between extreme exercise and significant weight loss to increased levels of oxidative stress.

“When we talk about oxidative stress, it’s really when the damage outweighs your ability to counter it with antioxidants.” - Patti Devers

This week on The Lab Report Podcast:

Understanding what ‘free radicals’ are and their connection to oxidative stress
The pros and cons of free radicals
How antioxidants help reduce oxidative stress
The main sources of antioxidants
The primary causes of free radicals in your body
The connection between certain chronic diseases and high levels of oxidative stress
How to measure oxidative stress
What SOD’s and glutathione do within the body
Debunking the misconception around ‘burning through your glutathione’
Taking glutathione supplements and what to consider before starting a glutathione supplement
How excessive exercise and significant weight loss can elevate your oxidative stress levels
The correlation between glutathione levels and pyroglutamic acid

Question of the Day:

When trying to assess heavy metals in a patient, is it better to use a urine test or a blood test?

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Don’t forget to visit our website, like us on Facebook, and follow us on Twitter, Instagram and LinkedIn. Email Patti and Michael with your most pressing questions on functional medicine.

For medical advice, diagnosis, and/or treatment, please consult a medical professional.

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Potential Pathogens on a Stool Test

Tue, 16 Feb 2021 11:00:00 +0000

When it comes to the gastrointestinal tract, we often focus on the balance of the commensal bacteria to optimize health. But, if that balance is interrupted, or the microbiome is lacking, some of the bacteria can overgrow. At higher levels of growth, patients can experience symptoms. There are also some important disease associations with overgrowth of specific species. Because of this potential, we designate these aerobic bacteria as potential pathogens.

On today’s episode, we unpack the concept of potential pathogens and talk about what to do- and what not to do- when you find them on a stool test.

Today on The Lab Report:

2:55 Potentially pathogenic bacteria – what are they and when should we worry?
7:30 Klebsiella - symptoms and systemic associations
10:52 Why you don’t always treat a potential pathogen
12:25 Concerns about Proteus
14:40 Citrobacter is common but has potential
15:45 Let’s Recap!
17:00 Question of the Day with Jim Kelton!
- What does 1+, 2+, 3+, 4+ mean on the GI Effects culture results?

Additional Resources:

Pathogenic Bacteria & Yeast Chart

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Patti & Michael Talk Wellness With Taylor Dukes

Fri, 12 Feb 2021 11:00:00 +0000

Taylor Dukes is functional medicine nurse practitioner with a burgeoning practice and growing online social media presence. Her expertise is vast - working with women in prenatal and postnatal care, helping professional athletes optimize performance, and improving the health of thousands of patients including CEO’s and celebrities.

On today’s show, we discuss her journey from conventional to functional medicine and her unique approach to wellness.

Today on The Lab Report:

3:20 Meet the fabulous Taylor Dukes
6:50 Taylor’s approach to fertility and postnatal care
10:05 Implementing functional medicine testing
11:25 Where to start with professional athletes
13:55 Telemedicine in practice
16:20 Work/Life balance for working moms
18:30 The Fireball

Additional Resources:

Taylor's website

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Kara Collier on Continuous Glucose Monitoring

Tue, 09 Feb 2021 11:00:00 +0000

Kara Collier is a registered dietician who specializes in continuous glucose monitoring (CGM). CGM is a wearable device that measures glucose levels throughout the day to evaluate your body’s response to dietary changes, stress, and exercise. Knowing this information can help you make personalized dietary and lifestyle changes to prevent metabolic dysfunction down the road or improve your current health.

On today’s episode, Kara explains the importance of CGM. We also discuss various patterns that might be seen and things you can do to optimize your daily choices.

Today on The Lab Report:

2:50 Kara Collier on her journey to nutrition technologies
6:15 What is CGM and how is NutriSense different?
11:00 Spike, area under the curve, average glucose variability
15:20 Glucose and stress/exercise
17:50 Ketogenic diets and CGM
19:35 Asymptomatic hypoglycemia
21:00 CGM in the menstrual cycle and interpersonal variability
25:55 The Fireball

Additional Resources:

NutriSense

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The Benefits of Hot & Cold Therapy

Fri, 05 Feb 2021 11:00:00 +0000

Using temperature therapeutically is becoming increasingly popular. Saunas and cold immersion ice baths are being touted in the biohacking community for overall longevity. Published research surely backs this up. The health benefits of thermogenesis and sauna are seen in cardiovascular disease, mood disorders, immune optimization, detoxification, and many other clinical conditions.

Today we discuss sauna and cold immersion with Andrew Nehlig and Jennifer Richter. They own and operate ‘Sauna House’, a premier Nordic-styled bathhouse located in Asheville, NC. They are passionate about their work and share their insight regarding the health benefits of sauna.

Today on The Lab Report:

3:00 Meet Andrew and Jen!
7:30 Different types of sauna
10:00 Amazing health benefits
14:15 How long? How often? Too much?
19:45 Immunity and sauna
21:23 Temperature therapy and mood
25:25 Hot then cold or cold then hot
29:05 The Fireball

Additional Resources:

Sauna House

Sauna, Heart Disease, and Decreased Mortality

Immunity and Temperature Therapy

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The Nutritional Physical Exam

Tue, 02 Feb 2021 11:00:00 +0000

The art of the physical exam is often overlooked in favor of testing. Although Genova’s nutritional profiles are designed to uncover subtle nutrient insufficiencies, there are many physical hints and clues which can give additional insights and perhaps lead you to consider testing. The areas of the body with rapid cell turnover are the first places to manifest these subtle changes.

On today’s episode, we resurrect the physical exam and review findings which may reflect your patient’s nutritional status.

Today on The Lab Report:

3:35 Is the physical exam dead?
5:25 Global observations
7:00 Hair and scalp
9:45 Mouth – tongue, gums, and dentition
15:35 Let’s Define Some Terms! – ‘Erythematous’
16:30 Skin bumps and rashes
18:50 Fingernails
21:00 Question of the Day
- How long does it take to reverse these findings with supplementation?

Additional Resources:

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Can you Identify SIBO On A Stool Test?

Fri, 29 Jan 2021 11:00:00 +0000

Today we dive into some specific patterns seen on stool testing that may point toward a SIBO diagnosis in symptomatic patients.

Today on The Lab Report:

2:50 IBS and bacteria in the small intestine
6:15 Symptoms of SIBO
7:35 Stool testing for IBS
9:05 Commensal abundance
10:00 Digestion and absorption markers
12:30 What do we think we know?
- Pancreatic elastase 1 and SIBO
16:35 Gut metabolites
17:50 Methanobrevibacter smithii and methane dysbiosis
19:50 Bacterial culture
20:50 Question of the Day
- How does methane slow transit time?

Additional Resources:

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Patti & Michael Cover the Electron Transport Chain

Tue, 26 Jan 2021 11:00:00 +0000

Today on The Lab Report:

2:15 Basic overview of cellular respiration and ATP
4:50 Breaking it down
7:45 The Krebs Cycle and NADH/FADH2
8:30 Electron Transport Chain and the bucket brigade
10:55 ATP Synthase is cool
13:20 High-level recap
14:15 Oxidative stress and CoQ10
17:30 Question of the Day:
- Who is Krebs?

Additional Resources:

ATP Synthase in action

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Astragalus: The Immunity Herb

Fri, 22 Jan 2021 11:00:00 +0000

Due to the pandemic, many of us are working from home, and looking to optimize our immunity. The behavioral and lifestyle changes we promote in functional medicine are key to having metabolic flexibility and immune system resiliency. However, there are supplements and herbs often used to improve the immune response. Astragalus is a root that has been used in Traditional Chinese Medicine for hundreds of years as it relates to infectious disease.

Today, we dive into herbal medicine and discuss the many health benefits of astragalus.

Today on The Lab Report:

3:20 Tinctures and extracting medicinal herbs
6:10 What is astragalus and why would we take it?
8:40 Plants are the basis for all medications
10:10 Astragalus – mechanism of action
13:30 What’s in a Name?
15:50 Question of the Day?
- How do herbal supplements affect test results?

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The Kynurenine Pathway

Tue, 19 Jan 2021 11:00:00 +0000

In functional medicine, the focus is on getting to the root cause of disease. Sometimes subtle nutritional insufficiencies can result in significant clinical consequences. By measuring steps in biochemical pathways called organic acids, we can uncover nutrient cofactor needs. One important biochemical process is the kynurenine pathway. The enzymes involved are highly dependent on vitamin B₆. Knowing this, abnormal organic acid levels within the kynurenine path can reveal vitamin B₆ insufficiencies. In addition, this pathway and its metabolites have important clinical implications.

In today’s episode, we discuss the importance of the kynurenine pathway, what each step means, how we measure them, and what you can do about it.

Today on the Lab Report:

2:35 The kynurenine pathway starts with tryptophan
5:15 What’s the end product and what drives this metabolism?
9:20 Kynurenic acid and NMDA receptors
11:30 Xanthurenic acid elevations
12:15 Quinolinic acid and why we worry about it
13:35 Ratio between KA and QA
14:35 Logical Speculation: Serotonin Tryptophan Steal
18:35 How and where we measure these organic acids
19:25 Question of the Day
- What about serotonin metabolites?

Additional Resources:

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The Omega-3 Fatty Acids

Fri, 15 Jan 2021 11:00:00 +0000

Dietary fat is broken down into fatty acids in our body. Fatty acids are important for many bodily functions including energy production, making cell membranes, and for signaling the inflammatory cascade. Among the several types of fatty acids, omega-3s have special benefits. Many people take supplements containing them in the form of fish oil. But, why? Can we get omega-3s in food? Why do we need them? How are they beneficial?

In today’s episode, we introduce the omega-3 fatty acids. We discuss their naming convention, their health benefits, and we single out a few of the main players.

Today on The Lab Report:

2:55 What is a fatty acid and where do those names come from?
7:05 The benefits of omega-3s
8:25 Dietary sources
12:05 Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA)
14:00 Supplementing with fish oil
17:35 Better Know a Biomarker
22:10 Question of the Day
- How do we decide which fish oil supplement is best?

Additional Resources:

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Patti & Michael Talk Detox

Tue, 12 Jan 2021 11:00:00 +0000

We live in a toxic world. Every day we are exposed to an array of environmental toxins in our air, water, soil, and food. Luckily, our body is well-equipped to handle most of them. Additionally, there are things we can do to help optimize the body’s detoxification process. Not only should we try to avoid toxins whenever possible, but we can also support the process of detoxification by focusing on nutrition, the GI tract, our skin, and proper hydration.

In today’s episode, we review steps in the body’s process of detoxification and speak to Dr. Christine Stubbe of Genova’s Medical Affairs team on her personal detox protocol.

Today on The Lab Report:

3:00 Exposures and the bucket analogy
5:30 Weight loss and toxin release
6:25 Physiologic steps of detoxification
10:35 Getting specific on detox protocols with Dr. Stubbe
16:25 The importance of preparation
19:45 Christine’s daily protocol
36:30 Question of the Day
- Which Genova testing profiles give insight into detox potential?

Additional Resources:

Agency for Toxic Substances and Disease Registry (ATSDR)

Detoxigenomic Profile

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Patti & Michael Talk Toxins

Fri, 08 Jan 2021 11:00:00 +0000

Our daily lives are filled with toxic exposures which can affect our health. Luckily, our bodies are well-quipped to handle and detoxify most of them. However, excessive exposures can lead to some subtle clinical presentations and eventually serious physical side effects.

In today’s episode, we discuss the sources of three common metal exposures, their physiologic importance, and how to test for them.

Today on The Lab Report:

3:05 Biotransformation -defining terms
7:00 Why do we care about heavy metal exposures?
9:05 Lead
13:30 Mercury
16:50 Arsenic
20:15 Genova testing options
24:20 Question of the Day:
- What form of mercury is being measured on the NutrEval?

Additional Resources:

Comprehensive Urine Elements Profile

Elemental Analysis

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Drew Manning: The Journey Back2Fit

Tue, 05 Jan 2021 11:00:00 +0000

Drew Manning is a health and fitness expert who became a world-wide sensation with his Fit2Fat2Fit experiment years ago. He gained and lost 75 pounds on purpose to understand the psychology of weight loss and bring empathy to the fitness industry. Currently, he is in the midst of repeating this feat as he turned forty years old in his Fit2Fat2Forty experiment.

Drew is halfway through after gaining 60 pounds and is about to journey back to fit. Today we check in on how he’s feeling and discuss what he’s learned so far.

Today on The Lab Report:

4:35 Drew Manning discusses the physical and emotional toll of weight gain
8:25 Empathy
9:25 The difference after turning 40
11:05 Social media influence
13:05 The effects of ‘dirty diets’
16:00 Preparing for the journey back to fit
18:40 Television series? Book? Documentary?
19:35 The Fireball

Additional Resources:

Back2Fit

Fit2Fat2Fit Experience Podcast

Fit2Fat2Fit: The Unexpected Lessons from Gaining and Losing 75lbs on Purpose

Complete Keto

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The Lab Report: A Year In Review

Fri, 01 Jan 2021 11:00:00 +0000

As the year 2020 comes to a close, Patti and Michael reflect back on the past year of The Lab Report podcast, which is approaching one year old. This new educational platform was created to spread the word about functional medicine and promote a focus on health and wellness. Throughout the year, we’ve covered many topics and interviewed some amazing guests. We laughed a lot and learned so much along the way.

As we head into the New Year, many people make resolutions to improve their health. In today’s episode we reflect on past shows and highlight some clinical pearls to help guide you into a healthy 2021.

Today on The Lab Report:

2:25 Back to the very beginning
5:10 What did we learn about diets?
13:00 Who doesn’t love jingles?
14:35 Movement, exercise, and motivation
19:55 Mindfulness and stress
23:00 Ok, now what? Where do you start?

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Dr. Austin Perlmutter on Habits, Behavior, and Your Brain

Tue, 29 Dec 2020 11:00:00 +0000

Dr. Austin Perlmutter is a board-certified internal medicine physician and New York Times best-selling author of the book Brain Wash. He has a special interest in helping patients understand their decisions and behavior as it relates to improving their health. Understanding unconscious habits and how the brain processes our environment is pivotal when it comes to helping patients and guiding their treatment – especially as many of us are making New Year’s resolutions.

In today’s episode, Dr. Perlmutter explains the ‘why’ behind our unhealthy decision-making and offers some strategies to change our behavior.

Today on The Lab Report:

2:40 Meet Dr. Perlmutter and learn about his focus on the brain
6:40 Prioritizing what’s good for us – knowledge, willpower, and blame
10:40 Freedom of choice and unconscious habits
15:30 Breaking the cycle of bad habits for the New Year
18:55 The effect of social media and news distractions
22:30 Protecting our brain – Brain Wash
27:45 The immune system beyond infectious disease
32:25 The Fireball

Additional Resources:

Brain Wash: Detox Your Mind for Clearer Thinking, Deeper Relationships, and Lasting Happiness

The Modern Brain - Psychology Today

drperlmutter.com

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The Holiday Extravaganza!

Tue, 22 Dec 2020 11:00:00 +0000

Today on The Lab Report:

2:50 Mistletoe – antioxidants and smoochie smoochie
5:00 Pine, conifers, and evil spirits
7:35 Peppermint candy canes and carminatives
10:35 Checking in with the UK – Oliver’s fear of figgy pudding
14:40 Gingerbread houses made from the super-herb
17:40 Gift-giving and ‘Off the Cuff’ with the Medical Affairs team
24:55 ‘Twas the Night Before Christmas ???????

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Vitamin D: The Sunshine Vitamin

Fri, 18 Dec 2020 11:00:00 +0000

Vitamin D is a fat-soluble vitamin with important physiologic effects. Unlike other vitamins that must be obtained from the diet, vitamin D can also be produced in the skin from sunlight. The health implications of vitamin D have been widely studied and some of these effects might surprise you.

In today’s episode, we describe how vitamin D is metabolized and why it is clinically important in the body. We also discuss supplementation and the confusion around optimal levels.

Today on The Lab Report:

2:45 Let’s define some terms!
5:10 Metabolism and activation of vitamin D
6:30 Difference between vitamin D₂ and D₃
8:50 The role of sunlight
10:00 VDRs, calcium homeostasis, and immunity
14:50 Vitamin D in glucose metabolism and effects in the brain
17:30 What are optimal levels?
20:45 Question of the Day:
- Can you get too much vitamin D?

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Dr. Alex Hutchinson on the Science of Endurance

Tue, 15 Dec 2020 11:00:00 +0000

In functional medicine, we often discuss behavioral change. But this can be difficult since many of us don’t like to be pushed out of our comfort zone. Dr. Alex Hutchinson is a physicist, endurance athlete, and author who writes about the perception of limits. How much of our physical limitations are real? Is it possible our minds are the actual limiting factor?

In today’s episode, Alex discusses his work on the human body’s capacity to endure. We talk about pain’s role in setting limits, and the psychology of pushing beyond what we think is possible.

Today on The Lab Report:

2:50 Meet Dr. Alex Hutchinson - from physics to journalism
7:45 Why is it so hard to be pushed out of our comfort zone?
10:00 Physical vs. mental limitations and the role of pain
15:30 Practical tips to understand and set limits
22:30 Nature vs. nurture
25:20 Malcolm Gladwell
28:00 The Fireball

Additional Resources:

ENDURE

Which Comes First, Cardio or Weights?

Big Ideas: 100 Modern Inventions That Have Transformed Our World

Sweat Science

Jockology

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Branched-Chain Amino Acids

Fri, 11 Dec 2020 11:00:00 +0000

Amino acids are the building blocks of life. They can be categorized as being essential or nonessential. Essential amino acids must come from the diet, while nonessential amino acids can be made in the body. Of the essential amino acids, there is a subgroup called the ‘branched chain amino acids (BCAAs).’ There are three BCAAs: leucine, isoleucine, and valine. These three amino acids have different molecular structures and important metabolic activity.

In this episode, we discuss the clinical importance of BCAA and how to interpret BCAA levels in context with organic acids.

Today on The Lab Report:

2:50 Let’s Define Some Terms!
5:10 The unique metabolism of BCAAs
6:30 BCAAs effects on the brain, muscle, and insulin resistance
12:30 What do we think we know?
- BCAAs and immunity
16:10 Measuring and interpreting amino acid patterns
17:55 Relating BCAA levels to urinary organic acids
21:00 Logical Speculation: Urinary alpha-keto acids and ketosis

Additional Resources:

Ceremides as modulators of cellular and whole-body metabolism

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Dr. Ben Bikman on Why We Get Sick

Tue, 08 Dec 2020 11:00:00 +0000

In this episode, we speak to Dr. Bikman about the mechanisms of insulin resistance, its far-reaching effects in chronic disease, and strategies to improve it.

Today on The Lab Report:

2:20 Meet Dr. Bikman and learn why he focuses his research on insulin
8:35 Insulin and insulin resistance
13:55 Where in the body does insulin resistance start?
18:25 Hypertrophic vs. hyperplastic fat cells and the effects of free fatty acids
26:35 Signals that create hypertrophic vs. hyperplastic fat cells
28:45 Muscle-centric model of insulin resistance
32:15 Chronic diseases as they relate to insulin resistance
35:50 Aromatase activity in adipose tissue
37:25 The brain and Alzheimer’s disease as ‘type 3 diabetes’?
41:50 Fasting, ketosis, and lifestyle strategies to combat insulin resistance
47:35 COVID-19, immunity, and metabolic defenses
50:40 The Fireball

Additional Resources:

Why We Get Sick

Adipose Tissue as an Endocrine Organ

Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics

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Pandit Dasa on Workplace Mindfulness

Fri, 04 Dec 2020 11:00:00 +0000

In the corporate world, the concept of mindfulness is not a priority. Multi-tasking, competition, and success are major drivers day-to-day. Pandit Dasa, a former monk, is an author and international speaker who teaches the concepts of appreciation and mindfulness to corporations to cultivate stronger relationships and teamwork. With more of us working remotely, this can be challenging. His simple advice is changing the culture of not only the workplace but the quality of interpersonal relationships at home.

In today’s episode, Pandit Dasa discusses his life in the monastery, strategies to foster appreciation amongst co-workers, and ways to be mindful in a tech-filled world.

Today on The Lab Report:

3:55 Pandit Dasa discusses his life in an NYC monastery
13:05 Cultivating teamwork in the workplace
16:05 Keeping connected while working remotely
18:25 Closing the Apps in our brain
20:55 The myth of multi-tasking
24:30 Dealing with social media and tech distraction
26:55 Mindfulness techniques and gratitude

Additional Resources:

Pandit's website

Closing the Apps

Urban Monk

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Shedding Some Light on Seasonal Affective Disorder

Tue, 01 Dec 2020 11:00:00 +0000

Today on The Lab Report:

2:15 The circadian rhythm and chronobiology – defining terms
5:00 Light signals and hormonal regulation of the biological clock
7:25 Health implications of seasonal change
9:30 Seasonal Affective Disorder
13:45 Vitamin D – What does it do?
18:10 Therapeutics and interventions
21:00 Question of the Day:
- Can seasonal affective disorder happen in the summer?

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The Thanksgiving Episode

Wed, 25 Nov 2020 11:00:00 +0000

Today on The Lab Report:

3:30 Turkey and tryptophan – is it a thing?
5:15 Cranberry sauce apologetics
7:45 Potatoes! - and the microbiome
10:35 Green bean casserole, (fake) mushrooms, and onions
13:15 Hollandaise sauce? Gravy? Stuffing? Ummm…moving on
14:10 Pumpkin is a fruit
15:20 Moderation and modifying your dinner
16:15 Movement and mindfulness
19:20 Gratitude and community – Patti & Michael give thanks

Additional Resources:

Michael's Famous Green Bean Casserole?

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Dr. Sandra Sheinbaum on Functional Medicine Coaching

Tue, 24 Nov 2020 11:00:00 +0000

Behavioral change is at the root of functional medicine as it relates to diet and lifestyle. Often patients struggle between office visits and need ongoing guidance and encouragement. Dr. Sandra Scheinbaum recognized the need to bridge this gap. After many years as a clinical psychologist, she pivoted her career to found the Functional Medicine Coaching Academy in association with the Institute for Functional Medicine.

On today’s episode, we learn about health coaches and why they are an integral missing piece when it comes to ensuring success on the path to optimal wellness.

Today on The Lab Report:

2:30 Meet Dr. Sandra Scheinbaum and hear about her career path
9:00 What does a health coach do and why are they important?
16:20 Health coaching during the pandemic
18:55 Positive psychology and training coaches
22:45 Focusing on personal character strengths
24:40 The Functional Medicine Coaching Academy
25:05 Basic skills to deal with panic attacks
28:50 The Fireball

Additional Resources:

The Functional Medicine Coaching Academy

Functional Medicine Coaching: How to Be Part of the Movement That's Transforming Healthcare

Functional Medicine Coaching: Stories from the Movement That's Transforming Healthcare

Stop Panic Attacks in 10 Easy Steps

How to Give Clients the Skills to Stop Panic Attacks: Don't Forget to Breathe

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Patti & Michael on Vitamin B-12

Fri, 20 Nov 2020 11:00:00 +0000

Vitamins are carbon-containing (organic) molecules that are essential for normal metabolism. However, they cannot be made in our body in sufficient amounts which makes dietary intake of vitamins important. There are thirteen different vitamins, categorized depending on whether they dissolve in water (water-soluble) or can be absorbed with dietary fat and stored in the body (fat-soluble).

In today’s episode, we focus on Vitamin B-12, the largest and most complex water-soluble vitamin. Hear about why we need it, how we get it, and what happens when you’re deficient.

Today on The Lab Report:

2:15 Vitamins and their naming conventions
4:35 What does vitamin B-12 do and how do we get it?
7:40 Signs and symptoms of deficiency and why it happens
11:00 Measuring levels of vitamin B-12
12:35 Better Know a Biomarker: Methylmalonic Acid
15:50 Daily dietary requirements and supplementation
21:50 Question of the Day:
- Should we be concerned about high levels of vitamin B-12?

Additional Resources:

Metabolic Analysis Profile

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How Sugar Affects the Brain with Dr. Nicole Avena

Tue, 17 Nov 2020 11:00:00 +0000

Dr. Nicole Avena is a neuroscientist, researcher, author, and speaker who has spent years studying nutrition and the brain chemistry of the reward system. She is a pioneer in the field of food addiction.

In functional medicine, we often talk about the importance of behavior and lifestyle changes to optimize health. But, how much of this is within our control? On today’s episode, Dr. Avena discusses the adverse effects of sugar on eating behaviors and the brain’s role in decision-making.

Today on The Lab Report:

3:00 Meet Dr. Nicole Avena and learn why she focuses on nutrition and food addiction
7:00 How sugar influences the brain chemistry of the reward system
10:20 Processed foods and added sugar
13:35 Reading nutrition labels and USDA recommendations
16:30 Long term effects of sugar on children
18:30 Advice for parents about introducing sugar in the diet
21:55 The Fireball

Additional Resources:

Dr. Nicole Avena's website

TED talk - How Sugar Affects the Brain

Why Diets Fail

What to Feed Your Baby and Toddler

What to Eat When You're Pregnant

Hedonic Eating: How the Pleasure of Food Affects Our Brains and Behavior

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Dr. Joseph Pizzorno: A Pioneer in Naturopathic Medicine

Fri, 13 Nov 2020 11:00:00 +0000

Dr. Joseph Pizzorno is a legend in the naturopathic and integrative medicine community. His decades of research, mentorship, and outreach have been instrumental in validating ‘science-based natural medicine’. As founding president of Bastyr University, and author of numerous textbooks and consumer books, his influence has shaped our current view of functional medicine.

Today, we reflect back on Dr. Pizzorno’s amazing career and discuss his latest research into toxic exposures, and his most recent publication on naturopathic approaches to COVID-19.

Today on The Lab Report:

3:20 Meet Dr. Joseph Pizzorno and learn about the evolution of integrative medicine
7:30 Optimism on the future of functional medicine
8:55 Pizzorno reflects on his influence and legacy
12:00 Textbook of Natural Medicine
13:45 Toxic exposures and environmental medicine
24:00 Naturopathic and functional medicine therapies for COVID-19
31:20 What’s next?
32:25 The Fireball

Additional Resources:

Textbook of Natural Medicine 5th Edition

Clinical Environmental Medicine

The Toxin Solution

Evidence Supporting a Phased Immuno-physiologic Approach to COVID-19 From Prevention Through Recovery

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Tom Malterre on the Exposome

Tue, 10 Nov 2020 11:00:00 +0000

Tom Malterre is a well-known nutrition expert and a certified functional medicine practitioner. Not only did Tom write a pivotal book on the elimination diet, but he also lectures frequently on environmental toxins, coaches groups of clinicians in functional medicine, and educates patients in his own clinical practice.

In today’s episode, Tom Malterre touches on several topics including the elimination diet, the metabolic effects of environmental toxins, and using food to assist detoxification and optimize health.

Today on The Lab Report:

2:40 Meet Tom Malterre and hear about his path to functional medicine
7:20 Clinical pearls for using the elimination diet
12:35 Environmental toxic exposures and metabolic effects
17:55 Toxic foods
21:44 Promoting detoxification
24:10 Talking to patients about minimizing toxic exposures
27:45 The Fireball

Additional Resources:

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Muscle-centric Medicine with Dr. Gabrielle Lyon

Fri, 06 Nov 2020 11:00:00 +0000

In this episode you’ll meet Dr. Gabrielle Lyon and learn about the metabolic influences of building muscle, how it contributes to longevity, and the importance of dietary protein.

Today on The Lab Report:

3:00 Meet Dr. Gabrielle Lyon and hear how her mentor has shaped her career
5:35 Metabolic and anti-inflammatory effects of muscle
9:45 Sarcopenia, insulin resistance, and obesity
11:10 Muscle mass and longevity
14:40 How much dietary protein do we need?
17:00 Animal vs. plant protein and supporting vegan/vegetarian patients
22:20 Red meat, flawed cancer studies, and mTOR
28:00 Lyon’s work with elite military operators
30:45 The Fireball

Additional Resources:

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Dr. Paul Anderson: A New View on Cancer

Tue, 03 Nov 2020 11:00:00 +0000

Dr. Paul Anderson has spent decades educating, writing, researching, and treating patients with many chronic illnesses. His expertise in alternative and complementary cancer therapies has garnered him a notable and distinguished reputation. As a professor at Bastyr University for many years, Dr. Anderson has helped shape the careers of many naturopathic physicians.

Today we discuss his approach to patients receiving a cancer diagnosis. He addresses nutrition, toxic exposures, and the mental-emotional aspects of cancer treatment to empower patients and their loved ones towards improved outcomes.

Today on The Lab Report:

2:50 Meet Dr. Paul Anderson and learn about his accomplished career
5:45 Epigenetics and the role of nutrition and toxic exposures
16:15 The controversy of antioxidants in cancer therapy
23:55 Diets and fasting to improve outcomes
32:25 Three pillars of cancer treatment
34:00 Personal empowerment in the face of diagnosis
37:25 Reframing a patient’s mental-emotional mindset
43:10 The Fireball

Additional Resources:

Dr. Anderson's website

Cancer: The Journey from Diagnosis to Empowerment

Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer

Success Breakthroughs

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Reset Your Cravings with Dr. Elena Zinkov

Fri, 30 Oct 2020 10:00:00 +0000

In functional medicine, behavior change is often at the heart of helping our patients improve their health. When it comes to dietary choices, many people struggle due to food cravings which they believe are out of their control. Dr. Elena Zinkov is a naturopathic physician who wrote a book which hits this topic straight on and offers helpful tips to reset cravings.

Today, we meet Dr. Zinkov and learn about her functional medicine approach to helping patients deal with food cravings.

Today on The Lab Report:

3:00 Meet Dr. Elena Zinkov and hear about her path to naturopathic medicine
5:30 Cravings are far more than willpower
7:55 Hormone imbalances, nutritional insufficiencies, and the microbiome
16:15 Neurotransmitters and cravings
20:00 Actionable steps to reset dietary behavior
26:15 The role of functional medicine laboratory testing
28:10 Improving sports performance in athletes
30:30 Zinkov’s thoughts on the optimal diet and fasting
34:50 The Fireball

Additional Resources:

Proactive Health

Crave Reset

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Dr. Mike T Nelson: A Holistic Approach to Coaching

Tue, 27 Oct 2020 10:00:00 +0000

Dr. Mike T. Nelson is an exercise physiologist, researcher, speaker, author, personal trainer, and coach. In the world of sports optimization, his approach is somewhat unique. Rather than merely focusing on training and personalized nutrition, his programs include some interesting alternative techniques to improve health and performance. Dr. Nelson’s years of research and coaching experience, paired with an open mind to new ideas, have garnered his clients amazing results. Today we discuss metabolic flexibility, alternative training therapies, and his approach to wellness.

Today on The Lab Report:

2:10 Meet Dr. Mike T. Nelson and hear about his path to exercise physiology
7:05 Reflexive Performance Reset
10:05 Alternative approaches to training therapies
17:55 Using HRV in athletes
23:00 Continuous glucose monitoring
26:55 Flex Diet
31:40 Mind-body practices
35:25 Optimal protein intake
38:00 Fasting in athletes
43:20 Mole
46:05 The Fireball

Additional Resources:

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The Thyroid Episode with Patti & Michael

Fri, 23 Oct 2020 10:00:00 +0000

The thyroid gland plays a major role in regulating our metabolism. It releases hormones that influence nearly every system in the body, in addition to other hormones. Because of its far-reaching effects, the symptoms of thyroid dysfunction are widely variable and often over-looked. In today’s episode we discuss how to identify thyroid abnormalities, how to measure it properly, and some functional medicine interventions to improve thyroid function.

Today on The Lab Report:

2:45 What is the thyroid and what does it do?
4:20 Symptoms of thyroid dysfunction
8:08 Thyroid hormone production and its physiologic cascade
12:45 Factors that influence each step of the thyroid hormone cascade
16:15 Autoimmunity and thyroid antibodies
17:45 T₃, T₄, and Reverse T₃
19:05 Laboratory measurement of thyroid function
24:10 Addressing root causes in treatment
26:00 Question of the Day:
- What can you do about an elevated reverse T₃?

Additional Resources:

Genova's Comprehensive Thyroid Assessment

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Dr Neil Paulvin: A 360 Degree Approach To Health

Tue, 20 Oct 2020 10:00:00 +0000

Dr. Neil Paulvin has created a truly integrative and comprehensive functional medicine practice in the heart of New York City. His specialties are varied including osteopathic manipulation, sports medicine, hormone imbalances, and overall biohacking. His innovative use of IV peptides, low dose naltrexone, and other anti-aging therapies has earned him an impressive reputation in the functional medicine space.

Dr. Paulvin joins us today to discuss how he combines his many tools to optimize patients’ health. We also dive into the use of low dose naltrexone in clinical practice.

Today on The Lab Report:

2:40 Meet Dr. Paulvin and learn about his path to functional medicine
4:55 The importance of recovery in sports medicine
7:55 Wearable devices in clinical practice
10:30 How and when to use low dose naltrexone (LDN)
18:10 Paulvin’s approach to the optimal diet
22:15 Functional medicine testing
23:25 Advice on transitioning to a functional medicine practice and using telemedicine
27:30 The Fireball

Additional Resources:

Dr. Paulvin's Website

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The Healing Power Of Laughter

Fri, 16 Oct 2020 10:00:00 +0000

There is the well-known phrase “laughter is the best medicine,” but is there any truth to that statement? In today’s show, Patti and Michael explore some of the research around laughter and its physiological, biochemical, and clinical effects. Also, if there is evidence to support laughter as a modality, does this mean we should be prescribing laughter as a treatment? What would this look like in clinical practice? Finally, we speak to some of the team members to demonstrate the power of laughter.

Today on The Lab Report:

2:30 Laughter fun facts
3:30 The MCET model
5:10 Clinical impact of laughter
10:00 Prescribing laughter – FITT evaluation
13:00 Round robin with the team
16:00 Culture influences and laughter evolution
18:30 Question of the Day:
- What’s the funniest thing that’s happened on the show?

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Navin Hettierachchi: Functional Medicine In Professional Sports

Tue, 13 Oct 2020 10:00:00 +0000

Professional athletes are seen as the pinnacle of health and performance. But the work that goes into ensuring their well-being can be daunting. Navin Hettierachchi has been working behind the scenes in professional sports for 20 years. In today’s episode, we hear about his functional medicine approach and the way he uses personalized medicine to help professional athletes achieve peak performance and be their best selves.

Today on The Lab Report:

2:30 Learn about Navin Hettierachchi and his path to sports medicine
7:00 Health, wellness, and functional labs in optimizing performance
10:45 The role of mind-body practices
14:00 Navin’s holistic REDT method
17:00 Personalized diets and fasting
23:45 Using continuous glucose monitoring and wearable devices
26:30 Functional exercise and movement
28:25 com
30:25 The Fireball

Additional Resources:

Navinhealth.com

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Patti & Michael Model Behavior Change

Fri, 09 Oct 2020 10:00:00 +0000

Most of what we do in functional medicine revolves around some type of behavioral change. Patients struggle with adopting these positive changes in diet, movement, and mindfulness. Instead of labelling patients as ‘noncompliant’, what if clinicians could meet patients where they are and help them through the process? The Transtheoretical Model was developed to help understand behavior and can be used in practice to promote compliance.

In today’s episode, we discuss the stages of behavior change and offer useful tips on how to approach coaching and educating patients.

Today on The Lab Report:

2:00 The Transtheoretical Model
5:10 Precontemplation and recognition
9:40 Contemplation and acceptance
12:10 Preparation and planning
14:30 Action and health coaching
16:45 Maintenance and new behavior
17:30 Question of the Day:
- What are the critiques of the Transtheoretical Model?

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Ashley VanHouten on Movement, Motivation, and Offal Eating

Tue, 06 Oct 2020 11:32:26 +0000

Ashleigh VanHouten is a key influencer in the health and fitness industry. As the self-proclaimed ‘Muscle Maven’, she coaches elite athletes and many nonathletic clients on ways to optimize their health. Ashleigh is not only a fitness expert, but also a well sought-after speaker, podcast host, and author of a new cookbook entitled It Takes Guts. Her book focuses on the importance of the often neglected, but nutritionally dense organ meats. Today we discuss her approach to a primally-aligned life, her thoughts on motivation and movement, and nose-to-tail eating.

Today on The Lab Report:

2:45 Meet Ashleigh VanHouten and hear about her passion for fitness and strength
8:35 The primally-aligned lifestyle
13:55 Balancing stress and maintaining motivation
17:45 Developing an exercise and movement habit
21:15 Ashleigh’s approach to diet and protein intake
26:15 Using fasting as a tool
30:10 Overtraining and the importance of recovery
35:45 It Takes Guts and eating offal
39:50 The Fireball

Additional Resources:

It Takes Guts

AshleighVanHouten.com

Muscle Maven Radio

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Patti & Michael Put Blastocystis On Blast

Fri, 02 Oct 2020 10:00:00 +0000

Blastocystis is one of the most common GI parasites encountered in clinical practice. There’s been some debate as to whether it’s friend or foe. There’s even more debate on how to treat it and whether it even needs to be treated. Newer technology shows that there are many different subtypes of Blastocystis. These subtypes may hold the key to understanding the nuances in clinical presentation and the difficulty in eradicating it.

Today we introduce Blastocystis and discuss how the subtypes may influence presentation and treatment.

Today on The Lab Report:

3:00 Blastocystis: Friend or Foe?
5:15 What kind of parasite is it, how do you get it, and what are the symptoms?
7:30 Subtypes and why we care
10:55 Treatment
13:30 Urticaria and Blastocystis?
15:00 What do we think we know? Natural therapies for Blastocystis
18:10 Question of the Day:
- Why doesn’t Genova offer antimicrobial sensitivities to parasites?
20:45 The Methane Dysbiosis Score

Additional Resources:

Genova's Stool Testing Support Guide

Parasitic Organisms Chart

Webinar - Parasitology Stool Diagnostics: From Basics to Blastocystis

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Unlocking Levels with Dr. Casey Means: Part 2

Tue, 29 Sep 2020 10:00:00 +0000

In the last episode, we met Dr. Casey Means – a head & neck surgeon who became a functional medicine practitioner and key opinion leader in plant-based diets. She also happens to be the Chief Medical Officer and co-founder of Levels. Levels produces digital health products, such as continuous glucose monitors, to inspire healthy behavior change.

Today, in Part 2 of our interview, Dr. Means explains how the continuous glucose monitor works and how valuable this information can be to overall metabolic health and wellness.

Today on The Lab Report:

2:35 Digital health care products and behavior change
7:50 Levels, continuous glucose monitors, and metabolic flexibility
12:00 How daily activities, diet, and fasting can affect continuous glucose monitor results
23:30 Combining CGM with functional nutritional testing
29:45 Stool testing and metabolic health
32:55 Casey’s Kitchen
37:45 The Fireball

Additional Resources:

Dr. Means' Website

Levels

Dr. Caseys Kitchen

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Unlocking Levels with Dr. Casey Means: Part 1

Fri, 25 Sep 2020 10:00:00 +0000

Today we meet Dr. Casey Means - a head & neck surgeon who made a big leap from traditional to functional medicine. She specializes in metabolic health with a focus on the whole-food, plant-based approach to diet. Dr. Means is also co-founder and Chief Medical Officer for a company called Levels . Levels produces digital health products, such as continuous glucose monitors, to inspire healthy behavior change.

In this episode, you’ll hear part 1 of an extensive interview discussing a variety of topics. Listen as we delve into Dr. Means’ path to functional medicine and her thoughts on plant-based diets.

Today on The Lab Report:

3:10 Introducing Dr. Casey Means and her path to functional medicine
11:10 Nutrigenomics and the plant-based diet
15:00 Curcumin and sulforaphane
16:25 What about meat?
19:00 Biochemistry and metabolizing fatty acids
21:20 What about other diets (keto, carnivore, etc.)?

Additional Resources:

Dr. Means' Website

Levels

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Patti & Michael Discuss The Gut-Brain Axis

Tue, 22 Sep 2020 10:00:00 +0000

Today we discuss some of the mechanisms by which this axis sends and receives those signals. We also talk about the importance of addressing both when optimizing health.

Today on The Lab Report:

2:30 New Game Alert! Vegetablization of names
4:05 Question of the Day/Fireball:

Since the gut-brain axis is bidirectional, where do you start when it comes to treatment?

6:45 What is the gut-brain axis?
8:10 Communication mechanisms from the GI tract to the brain
13:20 How the brain affects the gut
16:50 Where do you start when it comes to treatment?
18:20 Psychobiotics
20:10 Testing

Additional Resources:

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Healing The Gut: How Many R's Does It Take?

Fri, 18 Sep 2020 10:00:00 +0000

In functional medicine, we often focus on the GI tract to uncover and treat the root causes of many chronic diseases. But many clinicians just don’t know where to start. The “5R Protocol” is a helpful tool to guide treatment decision-making. The “5 R’s” are Remove, Replace, Re-inoculate, Repair, and Rebalance. What exactly does this mean? How do you translate this to clinical practice?

In this episode, we discuss the meaning of each “R”. We also explain how to apply these to a patient’s clinical presentation and stool test results.

Today on The Lab Report:

2:15 Introducing the “5R Protocol”
4:30 Remove - remove what? How?
13:30 Replace – supporting underlying GI function
21:40 Re-inoculate – pre- and probiotics
25:00 Repair – intestinal permeability and inflammation
27:45 Rebalance – lifestyle modification and the GI tract
30:10 Did we just add a sixth R? Yep!
30:50 Question of the Day: How long do you wait to retest?

Additional Resources:

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Drew Manning: Fit2Fat2Forty

Tue, 15 Sep 2020 10:00:00 +0000

Drew Manning is a health and fitness expert who became a world-wide sensation with his Fit2Fat2Fit experiment years ago. He gained and lost 75 pounds on purpose to understand the psychology behind weight loss. This transformed the way the fitness industry approached helping clients. He recently announced he’s doing it again this year as he turns 40 (Fit2Fat2Forty) to bring awareness to the mental-emotional part of body transformation.

In this episode, Drew discusses his latest journey and his new approach. Hear about the incredible amount of education he’s hoping to bring to this experiment and how you can follow along and learn. Additionally, because Drew is a leading voice in the ketogenic diet industry, we engage him in a rapid-fire “Keto FAQ” segment.

“Empathy is one of those things that can be so transformative and a huge catalyst for change.” – Drew Manning

Today on The Lab Report:

3:25 Meet Drew Manning and hear about why he’s undertaking “Fit2Fat2Forty”
7:15 What he learned from his first journey and how it changed his current approach
11:25 The psychology of gaining and losing weight
16:00 Mind-body practices for emotional eating
17:45 Gaining the weight - challenging popular diets
22:10 Rapid-fire Keto FAQ’s with Drew
29:00 The Fireball

Additional Resources:

@fit2fat2fit Instagram

Complete Keto Guide

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Breaking Down Protein with Patti & Michael

Fri, 11 Sep 2020 10:00:00 +0000

Proteins are large molecules made up of smaller building blocks called amino acids. As a macronutrient, protein can be obtained in our diet from both plants and animals. Protein is metabolically critical and structurally necessary to keep us healthy. When protein is broken down into amino acids, each of them have their own function and importance as well. Are you getting enough protein in your diet? What happens in the body if you’re deficient? How do you get more?

In today’s episode, we discuss all things protein. We also single out a few specific amino acids and touch on what makes them important.

Today on The Lab Report:

2:45 Introducing protein and amino acids
4:35 What’s the difference between a peptide and a protein?
6:00 How much protein do we need every day and where do we get it?
11:35 Protein digestibility and other important dietary factors
13:10 Amino acids – essential and nonessential
16:00 ‘Off the Cuff’ with the Medical Affairs Team: What’s your favorite amino acid?
31:35 How do we test amino acid levels?
33:00 Question of the Day: What are some patterns of amino acids and what do they mean?

Additional Resources:

Amino Acid Analysis

The Epstein-Barr Virus Solution

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The Multi-Omics Series Part 4: CBS and Transsulfuration

Tue, 08 Sep 2020 10:00:00 +0000

“You’ve got to zoom out. You’ve got to look at all of the factors which regulate the CBS enzyme.” – Michael Chapman, ND

Today on The Lab Report:

2:20 Reminder of what we mean by multi-omics
4:50 Introducing the CBS enzyme and the sink drain metaphor
7:40 The genetics of CBS – the silent mutation – and its potential effects
12:40 Better Know A Biomarker: Cystathionine!
16:20 Activators and inhibitors of CBS and its effects on other biomarkers
18:55 Question of the Day: Does a CBS SNP cause elevated ammonia levels?
21:40 Evaluating surrounding biomarkers and how do you treat this SNP?

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Functional Nutrition & EBV with Dr. Kasia Kines

Fri, 04 Sep 2020 10:00:00 +0000

Most of us in functional medicine understand the importance of nutrition in addressing chronic disease. Dr. Kasia Kines holds a doctorate degree in Clinical Nutrition and has helped thousands of patients get to the root cause of their illnesses. Dr. Kines also happens to be a key opinion leader on the Epstein-Barr virus and how reactivation of chronic EBV infection can impact health. In this episode, Dr. Kasia Kines discusses the interplay of nutrition, toxic exposures, and chronic EBV.

Today on The Lab Report:

3:45 Meet Dr. Kasia Kines and hear about her path to functional nutrition
8:40 Using nutrition to navigate a toxic world
11:00 Diet therapeutics and choices
17:50 Why did Dr. Kines choose to specialize in EBV?
26:20 Chronic EBV as a hidden trigger, reactivation, and susceptibility
32:55 Therapies for management of EBV
36:30 Stress and sleep in reactivation illness
39:40 The Fireball

Additional Resources:

EBVHelp

Kasia's website

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Dr. Bryan Walsh: Questioning Everything You Thought You Knew – Part 2

Tue, 01 Sep 2020 10:00:00 +0000

In the last episode, we met Dr. Bryan Walsh, a naturopathic physician and well-renowned teacher with a unique way of approaching medicine. He challenged us to remain humbly skeptic and excitedly curious. He spends his time scouring the literature and redefining his approaches to learning, teaching, and practicing clinical medicine.

Today he discusses the latest science on some tried and true traditional biomarkers and the art of applying them clinically.

“There is a science to blood chemistry, but there’s also an art.” – Dr. Bryan Walsh

Today on The Lab Report:

4:00 Revisiting traditional blood chemistries and the importance of the reference range
7:20 Using albumin as an example to tell a clinical story
19:05 Why Dr. Walsh developed his online teaching: “Metabolic Fitness Pro”
22:40 Knowing basic biochemistry and physiology is key
25:30 Stop looking for the next big thing, take a fresh look at the basics

Additional Resources:

Metabolic Fitness Pro

drwalsh.com

Dr. Walsh's YouTube Channel

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Dr. Bryan Walsh: Questioning Everything You Thought You Knew - Part 1

Fri, 28 Aug 2020 10:00:00 +0000

The history of medicine is riddled with shifting paradigms, disproven theories, and treatment protocols that may not be beneficial. Dr. Bryan Walsh is a naturopathic physician with a humble and deep curiosity which frames his unique approach to practicing medicine. By continually questioning the norm, he reminds us to dig deeper and follow the literature on topics that the medical community currently accepts as true.

Today’s episode is part one of our in-depth interview with Dr. Walsh where he discusses new ways of looking at detoxification and glucose regulation.

“We’ve been wrong before, what makes us think we’re right now. Let’s question things.” – Dr. Bryan Walsh

Today on The Lab Report:

2:40 Meet Dr. Bryan Walsh and hear about his overarching philosophies to medicine
8:45 Rethinking the concept of detoxification
13:35 Milk thistle and Curcumin: Friend or foe
16:05 Whole herb vs. Supercritical extracts
18:50 Missing conversations in glucose regulation
27:30 The importance of glycemic variability and ways to measure it

Additional Resources:

Metabolic Fitness Pro

drwalsh.com

Dr. Walsh's YouTube Channel

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Mind-Body Medicine with Dr. Brad Lichtenstein: Part 2

Tue, 25 Aug 2020 10:00:00 +0000

On our last episode, we introduced Dr. Brad Lichtenstein. Dr. Brad is a naturopathic physician who has spent his career teaching and practicing mind-body medicine, mindfulness, and meditation. This topic is crucial to optimal health, yet many patients find it intimidating and don’t know where to start. Today in part two of our interview, Dr. Brad dives into what mindfulness is, and how to cultivate mindful practices. Additionally, if you stick around to end of the show credits, Dr. Brad also leads us in a mindful meditation.

“Mindfulness means attention to the present moment without judgement or without elaboration. A lot of our suffering is because we are living in the judgement of something and missing the moment.” – Dr. Brad Lichtenstein

Today on The Lab Report:

3:05 What is mindfulness?
9:05 How can we incorporate mindfulness into our daily lives?
16:25 Attitudes regarding behavior change
22:30 Dealing with Zoom, social media, and devices
29:33 The Fireball: Dogs vs. Cats – which animal is more mindful?
34:30 Brad guides us in a ‘Mindfulness Meditation’

Additional Resources:

The Breath Space

Dr. Brad's TEDx Talk: Breathing Into Life

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Mind-Body Medicine with Dr. Brad Lichtenstein: Part 1

Fri, 21 Aug 2020 10:00:00 +0000

We are often reminded to adopt mindful practices in an attempt to mitigate the stress response and promote optimal health. But the concept can seem lofty and, at times, intimidating. Where do you start? How do you become more mindful? Finally, we hit this topic straight on. Dr. Brad Lichtenstein has dedicated his career to the practice of mind-body medicine, mediation, and mindfulness.

This episode is part one of a two-part interview with Dr. Brad. Today, he discusses the physiology of the stress response (“Fight, Flight, or Freeze”), types of biofeedback, and novel ways to engage and regulate the autonomic nervous system.

“The goal of measuring biofeedback is to create enough awareness in yourself that you no longer need the devices.”- Dr. Brad Lichtenstein

Today on The Lab Report:

4:15 Meet Dr. Brad Lichtenstein and learn about why he focuses on the nervous system
7:10 The Polyvagal theory and actively engaging the vagus nerve during stress
17:35 The importance of ‘safety’
22:55 Biofeedback: what is it, what are the different types, why do we care?
28:00 Emotional and physical responses as biofeedback regulation
33:00 Introduction to the concept of mindfulness – teaser!

Additional Resources:

The Breath Space

Dr. Brad's TEDx Talk: Breathing Into Life

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Cynthia Thurlow on Intermittent Fasting & Women's Health

Tue, 18 Aug 2020 10:00:00 +0000

On this podcast, we’ve discussed the benefits and shortcomings of many different diets. Today we finally delve into the concept of ‘fasting.’ Cynthia Thurlow, NP is a well-known expert in intermittent fasting, and became a viral sensation after her TEDx Talk on this subject. She is also passionate about optimizing women’s hormonal health.

Today we discuss the benefits of intermittent fasting, the different types of fasting, and Cynthia’s tips for women in their perimenopausal and menopausal years.

“Autophagy is the spring cleaning of the cells - getting rid of the ‘yuck’ your body doesn’t need.” -Cynthia Thurlow, NP.

Today on The Lab Report:

3:25 Meet Cynthia Thurlow and learn about her journey to functional medicine
11:25 Autophagy and the benefits of intermittent fasting
13:20 Types of fasting
15:10 Chronobiology, circadian rhythm, and fasting flexibility
19:25 What breaks a fast?
23:55 Contraindications to fasting
26:20 Prolonged fasting/water fasting
28:25 Addressing women’s hormonal health in perimenopause/menopause
32:40 Cynthia’s website, podcast, and online learning opportunities
34:00 The Fireball: What’s your favorite sandwich?

Cynthia's Website

Primal Eating

Cynthia's TEDx Talk on Intermittent Fasting

Cynthia's TEDx Talk on Surviving to Thriving

The Unhealthy Truth - Robyn O'Brien

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Patti & Michael Discuss GI Parasites

Fri, 14 Aug 2020 10:00:00 +0000

A parasite is an organism that lives in a host and takes its nourishment from that host. In the GI tract, their presence can manifest in many ways. The main classes of parasites include protozoa, roundworms, tapeworms, and flukes. Whenever Patti & Michael have questions about microbiology, they turn to Jim Kelton who has been part of the microbiology department at Genova for nearly 20 years. In this episode, we get Jim’s take on parasitosis and clarify the methodologies for detecting parasites.

“We developed fire back in the Stone Ages for a reason, and one of them was to cook fish.” – Jim Kelton

Today on The Lab Report:

3:40 Scienceness, Technicology, and Machine-a-mechanics: Jim Kelton is back!

4:40 Prevalence of parasitosis and the question of underdiagnosis

7:05 Are there commensal parasites?

11:40 Using different kinds of PCR to assess parasites

15:25 “But I saw a worm in my stool, and your lab missed it!”

17:05 Differentiating different ova/eggs

18:50 Microscopy and quantification scales

20:50 Sushi: Friend or foe

23:00 Parting thoughts and fun facts about parasites

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Hormone Testing; Where Do You Start?

Tue, 11 Aug 2020 10:00:00 +0000

Symptoms of hormonal imbalance can be highly variable - fatigue, weight gain, hot flashes, insomnia, and so much more. With that, it’s likely that hormonal imbalance is contributing to the root cause of many patient complaints. Often clinicians are confused about where to start when it comes to hormone testing. Which hormone do I look for? Which sample type is best? How does it all work together?

Today we discuss the delicate interplay of our hormones. We also highlight the testing differences between sample types (blood, urine, and saliva) and when you might choose one over the other.

Today on The Lab Report:

· 2:35 In which patients would you measure hormone levels?

· 4:30 The ‘pyramid analogy’ and interconnectedness of hormones

· 7:15 Cortisol and the stress response

· 8:40 Where does the thyroid fit in?

· 9:35 Sex hormones

· 12:05 Saliva vs. Blood vs. Urine – ‘Metaphorically Speaking with Dr. Stephen Goldman’

· 20:10 Question of the Day:

Why all the controversy about testing a patient on topical hormone therapy?

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Patti & Michael Weigh In on Weight Loss

Fri, 07 Aug 2020 10:00:00 +0000

Managing weight is more than calories in/calories out. There are many hidden factors that may be inhibiting weight loss such as hormonal influences, stress, toxic exposures, and maladaptive behaviors. One of the basic principles of functional medicine is that all patients are different and therefore, a personalized approach is needed.

In this episode, we redefine some ideas around weight loss and discuss the many factors that need to be considered in order to develop a successful weight loss strategy.

“The body system is innately designed to cure itself. To allow this to happen you need to remove the obstacles to cure.” – Dr. Michael Chapman

Today on The Lab Report:

· 2:50 Redefining terms

· 4:40 Calories in/calories out

· 7:25 Quality and quantity of food

· 12:35 Timing, fasting, and chronobiology

· 16:50 Hormones, the stress response, and the importance of sleep

· 21:50 What about the thyroid?

· 23:45 Environmental toxins and obesogens

· 25:00 Movement and exercise

· 25:45 A naturopathic approach to weight loss, obstacles to cure, and behavior change

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The Methylation Cycle: Deep Cuts

Tue, 04 Aug 2020 10:00:00 +0000

Methylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In our last episode, we introduced the topic of methylation and the basics of the biochemical reaction. However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance.

Today, we dive a bit deeper into the biochemistry and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Genova’s Methylation Pathway Handout to follow along.

“Should we do case studies on the podcast? Email your opinion to podcast@gdx.net!” – Patti and Michael

Today on The Lab Report:

2:50 Quick review of the methylation cycle
4:45 The important relationship between choline and betaine
7:05 Logical Speculation: Why is the betaine: choline ratio associated with disease risk?
9:35 Dimethylglycine (DMG)
11:15 Sarcosine and the ‘SAM disposal chute’
14:20 Glycine: What does it do?
16:55 Transsulfuration and glutathione
21:00 The multi-omics of the methylation panel
22:25 Question of the Day: What is the stability of measuring SAM and SAH?

Additional Resources:

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The Methylation Episode!

Fri, 31 Jul 2020 10:00:00 +0000

The word ‘methylation’ has become somewhat of a buzz word in functional medicine. We’ve mentioned it several times throughout many episodes of The Lab Report – hard to avoid since it’s involved in just about every biological process.

In this episode, we finally hit the topic head on and dive into the methylation cycle itself. Although the biochemistry can be intimidating, listen as we simplify and demystify the steps involved and why each is important. You may find it helpful to refer to a Methylation Pathway Chart.

“It’s not the reaction that is significant, but how often the reaction is used in the body.” – Michael Chapman, ND

Today on The Lab Report:

2:00 What is methylation and why is it clinically important
5:30 Jumping into the biochemistry – metaphors to the rescue!
11:35 Homocysteine
14:00 The main pathway versus back up pathway
19:33 Transsulfuration
22:30 Multi-omics and the methylation cycle
27:50 Question of the Day
- “What does it mean if homocysteine is low?”

Additional Resources: